Non-antibiotic Approaches to Preventing Pediatric UTIs: a Role for D-Mannose, Cranberry, and Probiotics?

Ching, Christina B.

doi:10.1007/s11934-022-01094-w

Cited by 9 publications

(4 citation statements)

References 95 publications

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“…Nevertheless, basing our research on a self-report internet survey resulted in a large sample size, which allowed to track the rUTIs prevalence (which is far less common than the typical UTI). Finally, future studies should test whether the relationship we observed can depend on the other perineal hygiene habits 32 and medication, probiotics or natural products use 33 . Unfortunately, we did not collect such data.…”

Section: Discussionmentioning

confidence: 93%

Extreme pubic hair removal as a potential risk factor for recurrent urinary tract infections in women

Galbarczyk,

Marcinkowska,

Klimek

et al. 2023

Sci Rep

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Urinary tract infections (UTIs) are the most common infections experienced by women. Previously, scalp and facial hair in men have been shown to inhibit the growth of pathogenic bacteria. Here we hypothesize that having hairy genitalia might protect women from UTI. This study investigated grooming habits and occurrence of UTIs in the past 12 months in 2409 women (aged 18–45). Women who reported removing all their pubic hair at least weekly were defined as extreme groomers (66.8%). We collected additional information on covariates including age, having a first UTI at or before age 15, spermicide use, having a new sex partner, and frequency of sexual intercourse during the past year. Extreme grooming was not associated with the risk of being diagnosed with UTI (OR = 1.17, 95% CI = 0.90–1.52), but was associated with a higher risk of recurrent UTIs, defined as three or more UTIs within 12 months (OR = 3.09, 95% CI = 1.35–7.06), after controlling for age, history of UTIs, and sexual practices. Other studies have found that hygienic purposes are the most common motivations for pubic hair removal. These results suggest that along with their pubes, women may be getting rid of important microbial niche and protection against recurrent UTIs.

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Section: Discussionmentioning

confidence: 93%

Extreme pubic hair removal as a potential risk factor for recurrent urinary tract infections in women

Galbarczyk,

Marcinkowska,

Klimek

et al. 2023

Sci Rep

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“…Additionally, we concentrated on clinical trials with adult patients. It is to be emphasized that respective studies using herbal drugs have also been done in children with psychosomatic diseases ( Verlaet et al, 2017 ; Schloss et al, 2021 ), IBS ( Menon et al, 2023 ), gastrointestinal disorders ( Michael et al, 2022 ), UTIs ( Ching, 2022 ), and URIs ( Mancak Karakus et al, 2023 ) to mention only some examples.…”

Section: Discussionmentioning

confidence: 99%

Current state of research on the clinical benefits of herbal medicines for non-life-threatening ailments

Salm,

Rutz,

van den Akker

et al. 2023

Front. Pharmacol.

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Herbal medicines are becoming increasingly popular among patients because they are well tolerated and do not exert severe side effects. Nevertheless, they receive little consideration in therapeutic settings. The present article reviews the current state of research on the clinical benefits of herbal medicines on five indication groups, psychosomatic disorders, gynecological complaints, gastrointestinal disorders, urinary and upper respiratory tract infections. The study search was based on the database PubMed and concentrated on herbal medicines legally approved in Europe. After applying defined inclusion and exclusion criteria, 141 articles were selected: 59 for psychosomatic disorders (100% randomized controlled trials; RCTs), 20 for gynecological complaints (56% RCTs), 19 for gastrointestinal disorders (68% RCTs), 16 for urinary tract infections (UTI, 63% RCTs) and 24 for upper respiratory tract infections (URTI) (79% RCTs). For the majority of the studies, therapeutic benefits were evaluated by patient reported outcome measures (PROs). For psychosomatic disorders, gynecological complaints and URTI more than 80% of the study outcomes were positive, whereas the clinical benefit of herbal medicines for the treatment of UTI and gastrointestinal disorders was lower with 55%. The critical appraisal of the articles shows that there is a lack of high-quality studies and, with regard to gastrointestinal disorders, the clinical benefits of herbal medicines as a stand-alone form of therapy are unclear. According to the current state of knowledge, scientific evidence has still to be improved to allow integration of herbal medicines into guidelines and standard treatment regimens for the indications reviewed here. In addition to clinical data, real world data and outcome measures can add significant value to pave the way for herbal medicines into future therapeutic applications.

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“…Lately, there has been an increasing interest in alternative methods for preventing UTIs, like immunotherapy, cranberry, and probiotics [ 10 , 11 , 12 , 13 , 14 , 15 ]. Using some probiotics appears to reduce the risk of UTIs [ 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Some intervention studies have reported whether administering specific Lactobacillus strains can prevent UTIs [ 37 , 38 ]. The most recent research showed diversity in the methodologies employed [ 14 , 16 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 versus Placebo as Prophylaxis for Recurrence of Urinary Tract Infections in Children

Daniel,

Szymanik-Grzelak,

Sierdziński

et al. 2024

Microorganisms

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Urinary tract infections (UTIs) rank among the most prevalent bacterial infections in children. Probiotics appear to reduce the risk of recurrence of UTIs. This study aimed to evaluate whether probiotics containing Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 therapy prevent UTIs in the pediatric population compared to a placebo. A superiority, double-blind, randomized, controlled trial was conducted. In total, 54 children aged 3–18 years with recurrent UTIs or ≥one acute pyelonephritis and ≥one risk factor of recurrence of UTIs were randomly assigned (27 patients in each arm) to a 90-day probiotic or placebo arm. The age, sex, diagnosis, renal function, risk factors, and etiology of UTIs did not vary between the groups. During the intervention, 26% of children taking the probiotic had episodes of UTI, and it was not significantly less than in the placebo group. The number of UTI episodes during the intervention and the follow-up period decreased significantly in both groups, but the difference between them was insignificant. We observed a decrease in UTIs during the study of almost 50% in the probiotic group compared to the placebo group. Probiotics can be used as natural, safe prophylaxis for children with risk factors for UTIs in whom antibiotic prevention is not indicated.

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Non-antibiotic Approaches to Preventing Pediatric UTIs: a Role for D-Mannose, Cranberry, and Probiotics?

Cited by 9 publications

References 95 publications

Extreme pubic hair removal as a potential risk factor for recurrent urinary tract infections in women

Extreme pubic hair removal as a potential risk factor for recurrent urinary tract infections in women

Current state of research on the clinical benefits of herbal medicines for non-life-threatening ailments

Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 versus Placebo as Prophylaxis for Recurrence of Urinary Tract Infections in Children

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