Non-Antibiotics Strategies to Control Salmonella Infection in Poultry

Ruvalcaba-Gómez, José Martín; Villagrán, Zuamí; Valdéz-Alarcón, Juan José; Martínez-Núñez, Marcelino; Gómez-Godínez, Lorena Jacqueline; Ruesga-Gutiérrez, Edmundo; Anaya-Esparza, Luis Miguel; Arteaga-Garibay, Ramón Ignacio; Villarruel-López, Angélica

doi:10.3390/ani12010102

Cited by 65 publications

(59 citation statements)

References 195 publications

(183 reference statements)

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“…The currently implemented strategies for overcoming antibiotic resistance rely on the alternative use of bacteriophages or their enzymes, the development of next-generation vaccines. Also important is the use of new feeding-based regimes for animals with prebiotics, probiotics, bacterial subproducts, and phytobiotics [ 3 ]. There is also great interest in proteins and peptides with bactericidal activity synthesized by bacteria, plants, invertebrates, vertebrates and mammals.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Resistance in Bacteria—A Review

et al. 2022

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Background: A global problem of multi-drug resistance (MDR) among bacteria is the cause of hundreds of thousands of deaths every year. In response to the significant increase of MDR bacteria, legislative measures have widely been taken to limit or eliminate the use of antibiotics, including in the form of feed additives for livestock, but also in metaphylaxis and its treatment, which was the subject of EU Regulation in 2019/6. Numerous studies have documented that bacteria use both phenotypis and gentic strategies enabling a natural defence against antibiotics and the induction of mechanisms in increasing resistance to the used antibacterial chemicals. The mechanisms presented in this review developed by the bacteria have a significant impact on reducing the ability to combat bacterial infections in humans and animals. Moreover, the high prevalence of multi-resistant strains in the environment and the ease of transmission of drug-resistance genes between the different bacterial species including commensal flora and pathogenic like foodborne pathoges (E. coli, Campylobacter spp., Enterococcus spp., Salmonella spp., Listeria spp., Staphylococcus spp.) favor the rapid spread of multi-resistance among bacteria in humans and animals. Given the global threat posed by the widespread phenomenon of multi-drug resistance among bacteria which are dangerous for humans and animals, the subject of this study is the presentation of the mechanisms of resistance in most frequent bacteria called as “foodborne pathoges” isolated from human and animals. In order to present the significance of the global problem related to multi-drug resistance among selected pathogens, especially those danger to humans, the publication also presents statistical data on the percentage range of occurrence of drug resistance among selected bacteria in various regions of the world. In addition to the phenotypic characteristics of pathogen resistance, this review also presents detailed information on the detection of drug resistance genes for specific groups of antibiotics. It should be emphasized that the manuscript also presents the results of own research i.e., Campylobacter spp., E. coli or Enetrococcus spp. This subject and the presentation of data on the risks of drug resistance among bacteria will contribute to initiating research in implementing the prevention of drug resistance and the development of alternatives for antimicrobials methods of controlling bacteria.

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Section: Introductionmentioning

confidence: 99%

Antibiotic Resistance in Bacteria—A Review

et al. 2022

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“…Moreover, to limit the development of antibiotic resistance, the European Union have forbidden to use of these compounds in livestock feed, and a partial ban for this has been announced in the US ( Wernicki et al., 2017 ). Therefore, finding novel therapies and preventive procedures against poultry infections caused by pathogenic bacteria, including S. enterica , became an urgent need ( Ruvalcaba-Gómez et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Biological aspects of phage therapy versus antibiotics against Salmonella enterica serovar Typhimurium infection of chickens

Kosznik-Kwaśnicka

Podlacha

Grabowski

et al. 2022

Front. Cell. Infect. Microbiol.

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Phage therapy is a promising alternative treatment of bacterial infections in human and animals. Nevertheless, despite the appearance of many bacterial strains resistant to antibiotics, these drugs still remain important therapeutics used in human and veterinary medicine. Although experimental phage therapy of infections caused by Salmonella enterica was described previously by many groups, those studies focused solely on effects caused by bacteriophages. Here, we compared the use of phage therapy (employing a cocktail composed of two previously isolated and characterized bacteriophages, vB_SenM-2 and vB_Sen-TO17) and antibiotics (enrofloxacin and colistin) in chickens infected experimentally with S. enterica serovar Typhimurium. We found that the efficacies of both types of therapies (i.e. the use of antibiotics and phage cocktail) were high and very similar to one another when the treatment was applied shortly (one day) after the infection. Under these conditions, S. Typhimurium was quickly eliminated from the gastrointestinal tract (GIT), to the amount not detectable by the used methods. However, later treatment (2 or 4 days after detection of S. Typhimurium in chicken feces) with the phage cocktail was significantly less effective. Bacteriophages remained in the GIT for up to 2-3 weeks, and then were absent in feces and cloaca swabs. Interestingly, both phages could be found in various organs of chickens though with a relatively low abundance. No development of resistance of S. Typhimurium to phages or antibiotics was detected during the experiment. Importantly, although antibiotics significantly changed the GIT microbiome of chickens in a long-term manner, analogous changes caused by phages were transient, and the microbiome normalized a few weeks after the treatment. In conclusion, phage therapy against S. Typhimurium infection in chickens appeared as effective as antibiotic therapy (with either enrofloxacin or colistin), and less invasive than the use the antibiotics as fewer changes in the microbiome were observed.

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“…The previous trend of studies related to searching for possible antibiotic alternatives (also used as antibiotic growth promoters) in animal production, so far has mostly focused on single components or mixtures of 2 to 3 active substances [ 30 , 31 ]. There are also reports with promising results, in the Salmonella spp.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Evaluation of Antimicrobial Effect of Phytobiotics Mixture on Salmonella spp. Isolated from Chicken Broiler

Iwiński

Wódz²,

Chodkowska³

et al. 2022

Antibiotics

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Background: The identification of natural antibacterial agents from various sources that can act effectively against disease-causing foodborne bacteria is one of the major concerns throughout the world. In the present study, a unique phytobiotics mixture containing thymol, menthol, linalool, trans-anethole, methyl salicylate, 1,8-cineole, and p-cymene was evaluated for antibacterial activity against selected strains of Salmonella spp. Results: The phytobiotics mixture was effective against Salmonella enterica subsp. enterica serovars Enteritidis, Typhimurium, and Kentucky. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of this unique mixture for these three pathogens were 1:256. Among these three strains, one S. Kentucky presented the most extensive resistance profiles to 18 antibiotics belonging to 5 classes of antibiotics. One of S. Typhimurium presents extensive resistance profiles to 14 antibiotics belonging to 5 classes of antibiotics. Conclusions: The results suggest that the phytobiotics mixture used in the experiment can be used as a strong natural antibacterial agent against Gram-negative foodborne pathogens such as S. Typhimurium, S. Kentucky, and S. Enteritidis. This is a preliminary analysis of the effectiveness of a phytobiotic product in an in vitro model, which may be the starting point for further studies, including in vivo animal models.

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Non-Antibiotics Strategies to Control Salmonella Infection in Poultry

Cited by 65 publications

References 195 publications

Antibiotic Resistance in Bacteria—A Review

Antibiotic Resistance in Bacteria—A Review

Biological aspects of phage therapy versus antibiotics against Salmonella enterica serovar Typhimurium infection of chickens

In Vitro Evaluation of Antimicrobial Effect of Phytobiotics Mixture on Salmonella spp. Isolated from Chicken Broiler

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