Non-apoptotic cell death in ovarian cancer: Treatment, resistance and prognosis

Chen, Jinghong; Wei, Zhichen; Fu, Kaiyu; Duan, Yuanqiong; Zhang, Mengpei; Li, Kemin; Guo, Tao; Yin, Rutie

doi:10.1016/j.biopha.2022.112929

Cited by 25 publications

(18 citation statements)

References 140 publications

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“…These completely physiological forms of RCD are often called programmed cell death (PCD) ( Galluzzi et al, 2018 ). Macroautophagy (hereafter referred to as autophagy) is a lysosome-driven, highly conserved catabolic process that is essential for the maintenance of homeostasis and is also the most common type of PCD ( Zhang et al, 2017 ; Chen J. et al, 2022 ). Damaged proteins and organelles are engulfed by intracellular phagocytes to produce autophagosomes, which then bind to lysosomes to form autolysosomes ( Zhang et al, 2017 ).…”

Section: The Perspective Of Circrnas In Ovarian Cancermentioning

confidence: 99%

“…There are different characters of autophagy in the types and stages of tumorigenesis. At the early stage, autophagy prevents tumorigenesis and restrains tumor progression ( Chen J. et al, 2022 ). While, once the tumor proceeds to advanced stages and is under stress from the intra- and extracellular environment, autophagy contributes to the survival and proliferation of the primary tumor and increases the aggressiveness of the tumor by promoting metastasis ( Chen J. et al, 2022 ).…”

Section: The Perspective Of Circrnas In Ovarian Cancermentioning

confidence: 99%

“…At the early stage, autophagy prevents tumorigenesis and restrains tumor progression ( Chen J. et al, 2022 ). While, once the tumor proceeds to advanced stages and is under stress from the intra- and extracellular environment, autophagy contributes to the survival and proliferation of the primary tumor and increases the aggressiveness of the tumor by promoting metastasis ( Chen J. et al, 2022 ). An increasing number of reports show that ncRNAs, including circRNAs, are associated with autophagy regulation.…”

Section: The Perspective Of Circrnas In Ovarian Cancermentioning

confidence: 99%

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Roles and mechanisms of CircRNAs in ovarian cancer

Liu

Cao

Guo

et al. 2022

Front. Cell Dev. Biol.

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Ovarian cancer (OC) is one of the female malignancies with nearly 45% 5-year survival rate. Circular RNAs (circRNAs), a kind of single-stranded non-coding RNAs, are generated from the back-splicing of cellular housekeeping noncoding RNAs and precursor messenger RNAs. Recent studies revealed that circRNAs have different biological function, including sponging miRNAs, encoding micropeptides, regulating stability of cytoplasmic mRNAs, affecting transcription and splicing, via interacting with DNA, RNA and proteins. Due to their stability, circRNAs have the potential of acting as biomarkers and treatment targets. In this review, we briefly illustrate the biogenesis mechanism and biological function of circRNAs in OC, and make a perspective of circRNAs drug targeting immune responses and signaling pathways in OC. This article can provide a systematic view into the current situation and future of circRNAs in OC.

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Section: The Perspective Of Circrnas In Ovarian Cancermentioning

confidence: 99%

Section: The Perspective Of Circrnas In Ovarian Cancermentioning

confidence: 99%

Section: The Perspective Of Circrnas In Ovarian Cancermentioning

confidence: 99%

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Roles and mechanisms of CircRNAs in ovarian cancer

Liu

Cao

Guo

et al. 2022

Front. Cell Dev. Biol.

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“…RCD in malignancies has been extensively studied and more and more pieces of evidence reveals that ferroptosis, necroptosis, and pyroptosis are highly involved the development, progression, and regression of OC ( 30 , 31 ). In this paper, we reviewed the molecular mechanisms of ferroptosis, necroptosis, and pyroptosis and their regulatory roles in OC, providing a new perspective on the pathogenesis and targeted therapy of OC and exploring their potential as potential therapeutic targets for death.…”

Section: Introductionmentioning

confidence: 99%

Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

Zhang

Liu

2022

Front. Immunol.

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Ovarian cancer (OC) is one of the most common malignancies that causes death in women and is a heterogeneous disease with complex molecular and genetic changes. Because of the relatively high recurrence rate of OC, it is crucial to understand the associated mechanisms of drug resistance and to discover potential target for rational targeted therapy. Cell death is a genetically determined process. Active and orderly cell death is prevalent during the development of living organisms and plays a critical role in regulating life homeostasis. Ferroptosis, a novel type of cell death discovered in recent years, is distinct from apoptosis and necrosis and is mainly caused by the imbalance between the production and degradation of intracellular lipid reactive oxygen species triggered by increased iron content. Necroptosis is a regulated non-cysteine protease–dependent programmed cell necrosis, morphologically exhibiting the same features as necrosis and occurring via a unique mechanism of programmed cell death different from the apoptotic signaling pathway. Pyroptosis is a form of programmed cell death that is characterized by the formation of membrane pores and subsequent cell lysis as well as release of pro-inflammatory cell contents mediated by the abscisin family. Studies have shown that ferroptosis, necroptosis, and pyroptosis are involved in the development and progression of a variety of diseases, including tumors. In this review, we summarized the recent advances in ferroptosis, necroptosis, and pyroptosis in the occurrence, development, and therapeutic potential of OC.

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“…Apoptotic cell death plays an important role in OV ( Hou et al, 2019 ). Ongoing development of targeted therapy allows non-apoptotic cell death to become popular in the field of prevention and treatment, including ferroptosis, alkaliptosis, autophagy, necroptosis, pyroptosis, immunogenic cell death as well as other cell death modes ( Chen et al, 2022a ). Necroptosis is a form of programmed necrosis, which differs from apoptosis as caspases activation is not involved in its progression.…”

Section: Introductionmentioning

confidence: 99%

Identification of necroptosis subtypes and development of necroptosis-related risk score model for in ovarian cancer

Wang

2022

Front. Genet.

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Background: ith the ongoing development of targeted therapy, non-apoptotic cell death, including necroptosis, has become a popular topic in the field of prevention and treatment. The purpose of this study was to explore the effect of necroptosis-related genes (NRGs) on the classification of ovarian cancer (OV) subtypes and to develop a necroptosis-related risk score (NRRS) classification system.Methods: 74 NRGs were obtained from the published studies, and univariate COX regression analysis was carried out between them and OV survival. Consensus clustering analysis was performed on OV samples according to the expression of NRGs related to prognosis. Furthermore, the NRRS model was developed by combining Weighted Gene Co-Expression Network Analysis (WGCNA) with least absolute shrinkage and selection operator (Lasso)-penalized Cox regression and multivariate Cox regression analysis. And the decision tree model was constructed based on the principle of random forest screening factors principle.Results: According to the post-related NRGs, OV was divided into two necroptosis subtypes. Compared with Cluster 1 (C1), the overall survival (OS) of Cluster 2 (C2) was significantly shorter, stromal score and immune score, the infiltration level of tumor associated immune cells and the expression of 20 immune checkpoints were significantly higher. WGCNA identified the blue module most related to necroptosis subtype, and 12 genes in the module were used to construct NRRS. NRRS was an independent prognostic variable of OV. The OS of samples with lower NRRS was significantly longer, and tumor mutation burden and homologous recombination defect were more obvious.Conclusion: This study showed that necroptosis plays an important role in the classification, prognosis, immune infiltration and biological characteristics of OV subtypes. The evaluation of tumor necroptosis may provide a new perspective for OV treatment.

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Non-apoptotic cell death in ovarian cancer: Treatment, resistance and prognosis

Cited by 25 publications

References 140 publications

Roles and mechanisms of CircRNAs in ovarian cancer

Roles and mechanisms of CircRNAs in ovarian cancer

Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

Identification of necroptosis subtypes and development of necroptosis-related risk score model for in ovarian cancer

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