Non-Arteritic Ischemic Optic Neuropathy Following COVID-19 Vaccination in Korea: A Case Series

Moon, Yeji; Jung, Jae Ho; Shin, Hyun Jin; Choi, Dong Gyu; Park, Kyung-Ah; Jeon, Hyeshin; Lee, Byung Joo; Kim, Seong-Joon; Oh, Sei Yeul; Ahn, Hyosook; Chung, Seung Ah; Kim, Ungsoo; Lee, Haeng Jin; Lee, Joo Yeon; Choi, Youn Joo

doi:10.3346/jkms.2023.38.e95

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…Studies on macular fluid with acute AION have reported prevalence rates of 19-47%. 24,26,30 In our cohort, macular fluid was noted in 73% of the eyes. However, SRF was only noted in 36% of the eyes and was reaching the subfoveal area in 75% of the eyes and limited to the peripapillary area in 25% of the eyes.…”

Section: Described a Case Of Crao In An Elderly Femalementioning

confidence: 54%

Prevalence and Distribution of Macular Fluid with Central Retinal Artery Occlusion and Anterior Ischemic Optic Neuropathy

Fouad,

Hamza,

Wessam

2024

OPTH

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Purpose To examine the prevalence and distribution of fluid within a cohort of eyes with acute central retinal artery occlusion (CRAO) and non-arteritic anterior ischemic optic neuropathy (AION) using optical coherence tomography (OCT). Methods A retrospective analysis of patient records and OCT imaging. Patients presenting with acute CRAO or AION who had available macular OCT imaging and no co-morbidities known to cause macular fluid were included in the analysis. Baseline characteristics, visual acuity (VA), and fluid presence and distribution among the retinal layers were recorded. Results In the 16 eyes with acute CRAO, fluid was noted in 5 eyes (31%), which was mainly subretinal (3 eyes) or intraretinal located within the outer retinal layers (3 eyes). Only one eye had inner retinal cysts. Of the 11 eyes with acute AION, fluid was present in 8 eyes (73%). Subretinal fluid was noted in 4 eyes and extended to the foveal area in 3 of them, and outer retinal versus inner retinal cysts were noted in 6 versus 3 eyes, respectively. None of the eyes showed hard exudate deposition. In the small subset of eyes with CRAO and macular fluid that were followed-up, VA improved, while in eyes with AION, VA remained stable. Conclusion Macular fluid on OCT is not an uncommon feature of acute CRAO and AION and is mainly distributed within the outer retinal layers or subretinal space. Fluid is an understudied feature of retinal and optic nerve head infarction and may have a role in predicting neuronal damage extent and visual outcome.

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Section: Described a Case Of Crao In An Elderly Femalementioning

confidence: 54%

Prevalence and Distribution of Macular Fluid with Central Retinal Artery Occlusion and Anterior Ischemic Optic Neuropathy

Fouad,

Hamza,

Wessam

2024

OPTH

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“…NAION was rarely reported to be associated with vaccination in the past. According to a case series, which included 14 patients who developed NAION after COVID-19 vaccinations, 50% of patients had no known vascular risk factors before the diagnosis of NAION 140 . It was, therefore, believed that COVID-19 vaccination may predispose patients to an increased risk of NAION.…”

Section: Neuro-ophthalmic Adverse Events To Coronavirus Disease 2019 ...mentioning

confidence: 99%

“…According to a case series, which included 14 patients who developed NAION after COVID-19 vaccinations, 50% of patients had no known vascular risk factors before the diagnosis of NAION. 140 It was, therefore, believed that COVID-19 vaccination may predispose patients to an increased risk of NAION. Studies have reported that the administration of COVID-19 viral vector-based vaccines and mRNA-based vaccines could result in thrombotic events.…”

Section: Neuro-ophthalmic Adverse Events To Coronavirus Disease 2019 ...mentioning

confidence: 99%

Update on coronavirus disease 2019: Ophthalmic Manifestations and Adverse Reactions to Vaccination

Lin,

Sen,

Gupta

et al. 2023

Asia-Pacific Journal of Ophthalmology

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The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 was one of the most devastating public health issues in recent decades. The ophthalmology community is as concerned about the COVID-19 pandemic as the global public health community is, as COVID-19 was recognized to affect multiple organs in the human body, including the eyes, early in the course of the outbreak. Ophthalmic manifestations of COVID-19 are highly variable and could range from mild ocular surface abnormalities to potentially sight and life-threatening orbital and neuro-ophthalmic diseases. Furthermore, ophthalmic manifestations may also be the presenting or the only findings in COVID-19 infections. Meanwhile, global vaccination campaigns to attain herd immunity in different populations are the major strategy to mitigate the pandemic. As novel vaccinations against COVID-19 emerged, so were reports on adverse ophthalmic reactions potentially related to such. As the world enters a post-pandemic state where COVID-19 continues to exist and evolve as an endemic globally, the ophthalmology community ought to be aware of and keep abreast of the latest knowledge of ophthalmic associations with COVID-19 and its vaccinations. This review is a summary of the latest literature on the ophthalmic manifestations of COVID-19 and the adverse ophthalmic reactions related to its vaccinations.

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Cranial neuropathy following coronavirus disease 2019 vaccination in kidney transplant recipients

Fukae,

Yamanaka,

Matsumura

et al. 2024

IJU Case Reports

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IntroductionUnderstanding of adverse reactions to coronavirus disease 2019 vaccines remains limited.Case presentationCase 1: A 52‐year‐old woman, post‐kidney transplantation, experienced sudden vision loss in her left eye after receiving a second dose of coronavirus disease 2019 vaccine. She was diagnosed with ischemic optic neuropathy.Case 2: A 53‐year‐old woman, post‐kidney transplantation, presented with worsening diplopia and left eye pain following the second dose of coronavirus disease 2019 vaccine. She was diagnosed with left abducens nerve palsy.ConclusionVigilance is essential for recognizing the potential for delayed cranial neuropathy in immunocompromised individuals after coronavirus disease 2019 vaccination.

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Non-Arteritic Ischemic Optic Neuropathy Following COVID-19 Vaccination in Korea: A Case Series

Cited by 4 publications

References 35 publications

Prevalence and Distribution of Macular Fluid with Central Retinal Artery Occlusion and Anterior Ischemic Optic Neuropathy

Prevalence and Distribution of Macular Fluid with Central Retinal Artery Occlusion and Anterior Ischemic Optic Neuropathy

Update on coronavirus disease 2019: Ophthalmic Manifestations and Adverse Reactions to Vaccination

Cranial neuropathy following coronavirus disease 2019 vaccination in kidney transplant recipients

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