Non-autoimmune diabetes mellitus and the risk of virus infections: a systematic review and meta-analysis of case-control and cohort studies

Lontchi-Yimagou, Eric; Feutseu, Charly; Kenmoe, Sébastien; Zune, Alexandra Lindsey Djomkam; Ekali, Solange Fai Kinyuy; Nguewa, J.-L.; Choukem, Siméon Pierre; Mbanya, Jean Claude; Gautier, J.-F.; Sobngwi, Eugène

doi:10.1038/s41598-021-88598-6

Cited by 16 publications

(15 citation statements)

References 97 publications

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“…A continuous presence of high glucose levels at the peripheral cells may result in several abnormalities that favour both bacterial and viral infection. 89 The exact consequence of hyperglycaemia favouring viral infections such as SARS-CoV-2 infection is discussed in subsequent sections.…”

Section: Okoduwa Sir Et Al Hypothetic Mechanism Of Diabetes Mellitus ...mentioning

confidence: 99%

Diabetes Mellitus and COVID-19: Possible Interactions and Mechanisms in Comorbid Patients

Okoduwa

Mhya

Enang³

et al. 2022

J Health Sci Med Res

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Beginning in December 2019 and still ongoing, coronavirus disease 2019 (COVID-19) infections have posed a public health challenge worldwide. There have been reports of diabetes mellitus (DM) as one of the most prevalent comorbidities in patients with COVID-19. Although the interactions and possible mechanisms of this association have not been fully established, the existence of DM is believed to aggravate the adverse effects of COVID-19 infection. Hence, the need for this paper. Findings from other studies have shown different possible mechanisms of how COVID-19 and DM aggravate the severity of each other. Among the hypothetical mechanisms reported between COVID-19 and DM in this paper are: COVID-19 causes complications of DM through the following: (1) Destruction of β-cells in the pancreas by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. (2) Cytokine storm generation which mediates tissue inflammation resulting in organ damage and (3) The use of corticosteroid drugs which have been found to be highly diabetogenic. Similarly, DM facilitates internalizing of SARS-CoV-2 symptoms through increasing expression of angiotensin-converting enzyme 2 (ACE2) and the furin protein, viral load, entrance and replication of SARS-CoV-2, glycosylation, and compromising of the immune response that worsens COVID-19. Having a clear understanding of the biochemical mechanisms of interactions between COVID-19 and DM may be useful for future research of agents targeted as therapeutic remedies for managing patients with diabetes infected with COVID-19 and vice versa.

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Section: Okoduwa Sir Et Al Hypothetic Mechanism Of Diabetes Mellitus ...mentioning

confidence: 99%

Diabetes Mellitus and COVID-19: Possible Interactions and Mechanisms in Comorbid Patients

Okoduwa

Mhya

Enang³

et al. 2022

J Health Sci Med Res

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“…For example, tuberculosis and type 2 diabetes have been shown to facilitate one another, creating a double burden of two epidemics in several countries [ 14 ]. Links between type 2 diabetes and viral infections have also been demonstrated, generally with the conclusion that diabetes precedes and increases the risk of the viral infection [ 15 ]. A recent meta-analysis estimated increased prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; OR 10.8), hepatitis C (OR 3.6), hepatitis B (OR 1.6) and other viruses among type 2 diabetic patients [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…With regard to human herpesviruses, an increased prevalence of HHV8 among type 2 diabetic patients has been reported in multiple populations [ 15 – 17 ]. Some cross-sectional studies have also demonstrated an association of HSV1 and CMV serostatus with prevalence of type 2 diabetes [ 15 , 18 – 20 ], but the results were partly confounded by age and other demographic factors [ 21 ]. Moreover, the cross-sectional nature of these studies means that they cannot demonstrate chronology or causality [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Health impact of seven herpesviruses on (pre)diabetes incidence and HbA1c: results from the KORA cohort

et al. 2022

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Aims/hypothesis The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their potential role in diabetes aetiology. Methods Two follow-up examinations of the German population-based KORA cohort (F4 and FF4) were used to identify participants with normal glucose tolerance at baseline, thus being at risk for (pre)diabetes (n = 1257). All participants had repeated OGTTs and antibody measurements for herpes simplex virus (HSV) 1 and 2, varicella-zoster virus, Epstein–Barr virus, cytomegalovirus (CMV) and human herpesvirus 6 and 7. Regression models were used to evaluate the association between serostatus with (pre)diabetes incidence after a 7 year follow-up and HbA1c. Results HSV2 and CMV were associated with (pre)diabetes incidence after adjustment for sex, age, BMI, education, smoking, physical activity, parental diabetes, hypertension, lipid levels, insulin resistance and fasting glucose. Seropositivity of both viruses was also cross-sectionally associated with higher HbA1c at baseline, with the association of HSV2 being independent of confounders, including the prevalence of (pre)diabetes itself. While seropositivity for multiple herpesviruses was associated with a higher incidence of (pre)diabetes, this association was not independent of confounders. Conclusions/interpretation The associations of HSV2 and CMV serostatus with (pre)diabetes incidence indicate that these herpesviruses may contribute to the development of impaired glucose metabolism. Our results highlight the link between viral infection and (pre)diabetes, and the need for more research evaluating viral prevention strategies. Graphical abstract

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“…Age, genetic inheritance, environmental variables, lifestyle choices, infections that increase the likelihood of developing T2DM, and others make up the likely etiology. Since viruses and T2D may coexist in an individual through direct or indirect viral-mediated pathways, viral infections appear to be highly related with non-autoimmune diabetes (6)(7) .…”

Section: Introductionmentioning

confidence: 99%

Study on Viral Infection and Related Parameters in A Sample of Diabetes Mellitus Type 2

Hussein¹,

Salloom²

2022

The Egyptian Journal of Hospital Medicine

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Background: High levels of blood glucose brought on by insulin resistance or deficiency characterize diabetes mellitus type 2, a metabolic condition. One of the main factors contributing to diabetes is viral infection. One of the viruses connected to T2DM is the cytomegalovirus (CMV). Analysis of viral infection and associated factors in a type 2 diabetes sample. Objective: The aim of this study is to measure levels of anti-CMV virus IgG in serum of Iraqi patients with Type 2 diabetes mellitus disease and measure the levels of some markers including age, gender, FBS, HbA1c, s. creatinine, blood urea and lipid profile (cholesterol, triglyceride, HLD, LDL, and VLDL). Materials and Methods: This study involved 100 T2DM patients (52 males and 48 females) who visited Al-Karamah Teaching Hospital and Baghdad Teaching Hospital, and 52 healthy Iraqi subjects (control) (26 males and 26 females). In addition to the measures used in this investigation, which also included the lipid profile, HbA1c, FBS, serum creatinine, and blood urea, Anti-CMV IgG was also measured for 48 patients and 40 controls. Results: In comparison with the control group, B. urea, S. creatinine, Anti-CMV IgG, and lipid profile (excluding HDL) were considerably higher in the patient group. While there was no statistically significant difference between groups in terms of age and HDL levels, there was a difference. Conclusion:As indicators and cofactors for type 2 diabetes mellitus, particular laboratory tests and Anti-CMV viral IgG might be utilized.

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Non-autoimmune diabetes mellitus and the risk of virus infections: a systematic review and meta-analysis of case-control and cohort studies

Cited by 16 publications

References 97 publications

Diabetes Mellitus and COVID-19: Possible Interactions and Mechanisms in Comorbid Patients

Diabetes Mellitus and COVID-19: Possible Interactions and Mechanisms in Comorbid Patients

Health impact of seven herpesviruses on (pre)diabetes incidence and HbA1c: results from the KORA cohort

Study on Viral Infection and Related Parameters in A Sample of Diabetes Mellitus Type 2

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