Abstract. In this paper we study the following non-autonomous stochastic evolution equation on a Banach space E:Here, (A(t)) t∈ [0,T ] (SE). If the coefficients also satisfy a linear growth condition, then it is shown that the solution exists globally. Under assumptions on the interpolation spaces we extend the factorization method of Da Prato, Kwapień, and Zabczyk, to obtain space-time regularity results for the solution U of (SE). For Hilbert spaces E we obtain a maximal regularity result. The results improve several previous results from the literature. The theory is applied to a second-order stochastic partial differential equation which has been studied by Sanz-Solé and Vuillermot. This leads to several improvements of their result.