Non-Bariatric Roux-en-Y Gastric Bypass

Roux-en-Y reconstruction alleviates radical gastrectomy-induced colitis via down-regulation of the butyrate/NLRP3 signaling pathway

“…Anatomical changes caused by different gastrointestinal reconstruction methods may have different effects on intestinal hormone levels. 7 , 8 , 9 In patients with GC accompanied by type 2 diabetes, related clinical indicators were improved in 27.8% of the patients who received R-Y reconstruction and 5.9% of those who received B-II reconstruction, and their body mass index (BMI) values were correspondingly reduced, although the improvement rate was lower than that of obese patients undergoing gastric reduction surgery as described in previous studies. 9 , 10 …”

Systematic review on sleeve gastrectomy or Roux-en-Y gastric bypass surgery for refractory gastroparesis

“…Once this cannot be achieved, gastroparesis is considered to be decompensated, and sequential treatment steps are needed [4]. Although no information was known about the amount of weight lost before, at the time of, or during conservative management of a diagnosis of gastroparesis, reported BMI values of studied patients is noticeably high: a median or mean BMI .25 kg/m 2 preoperatively for 9 included studies [13,15,17,24,26,28,29,34,36]. Only 1 study reported results separately for patients with obesity with refractory gastroparesis and malnourished gastroparesis patients (defined as a weight loss of 5% in 1 month or of 10% in 6 months or a BMI of ,18.5 kg/m 2 with a 50% reduction in food intake) and reports favorable outcomes in terms of symptoms but also weight/BMI changes in both groups at 1 year postoperatively [35].…”

“…1). Finally, 19 studies were included in this systematic review, including a total of 222 patients with gastroparesis, of whom 147 patients received Roux-en-Y gastric bypass surgery, reported in 12 studies [17][18][19][20][21][25][26][27][28][29]34,35]; 39 patients underwent sleeve gastrectomy, reported in 5 studies [13,15,16,23,36]; and 36 patients underwent subtotal or near-total gastrectomy, reported in 2 studies [24,37] (Table 1). Eighteen studies were full-text articles, and 1 study was a conference abstract [36].…”

“…Seven studies were case reports [13,15,18,19,25,36,37], and 12 studies were retrospective observational studies [16,17,20,21,23,24,[26][27][28][29]34,35]. Based on NIH quality assessment, 4 studies had good quality, and the other 15 studies were of fair quality (Table 2).…”

“…Indications for reoperation included leakage of the anastomosis (n 5 7 patients), small bowel obstruction (n 5 2 patients), and internal herniation (n 5 1 patient); the reason for reoperation was not specified for 5 patients [28]. There were 8 studies [13,15,[17][18][19]25,34,37] that reported no postoperative complications (of a total of 21 studied patients from these studies), whereas in the remaining 11 studies (including a total of 201 patients), a total of 49 adverse events were reported.…”