Non-BOLD contrast for laminar fMRI in humans: CBF, CBV, and CMRO2

Huber, Laurentius; Uludağ, Kâmil; Möller, Harald E.

doi:10.1016/j.neuroimage.2017.07.041

Cited by 119 publications

(133 citation statements)

References 193 publications

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“…T2‐weighted sequences, such as GRASE (De Martino et al, ; Kemper, De Martino, Yacoub, & Goebel, ; Kemper et al, ), and sequences that are not based on the BOLD contrast, such as VASO (Huber et al, ; Huber, Uludağ, & Möller, ) and ASL (Huber et al, ; Pfeuffer et al, ; Uludağ et al, in preparation), are less affected by vascular biases and are therefore expected to yield a better estimation of local neuronal activity compared with GE sequences. However, this advantage comes at the price of a lower sensitivity and/or decreased coverage.…”

Section: Discussionmentioning

confidence: 99%

“…T2-weighted sequences, such as GRASE (De Martino et al, 2013;Kemper, De Martino, Yacoub, & Goebel, 2015;Kemper et al, 2016), and sequences that are not based on the BOLD contrast, such as VASO (Huber et al, 2014(Huber et al, , 2015Huber, Uluda g, & M€ oller, 2017b) and…”

Section: Limitations and Directions For Future Researchmentioning

confidence: 99%

“…ASL (Huber et al, 2017b;Pfeuffer et al, 2002;Uluda g et al, in preparation), are less affected by vascular biases and are therefore expected to yield a better estimation of local neuronal activity compared with GE sequences. However, this advantage comes at the price of a lower sensitivity and/or decreased coverage.…”

Section: Limitations and Directions For Future Researchmentioning

confidence: 99%

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Cortical depth profiles of luminance contrast responses in human V1 and V2 using 7 T fMRI

Marquardt

Schneider

Gulban

et al. 2018

Human Brain Mapping

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Neural activity in early visual cortex is modulated by luminance contrast. Cortical depth (i.e., laminar) contrast responses have been studied in monkey early visual cortex, but not in humans. In addition to the high spatial resolution needed and the ensuing low signal-to-noise ratio, laminar studies in humans using fMRI are hampered by the strong venous vascular weighting of the fMRI signal. In this study, we measured luminance contrast responses in human V1 and V2 with high-resolution fMRI at 7 T. To account for the effect of intracortical ascending veins, we applied a novel spatial deconvolution model to the fMRI depth profiles. Before spatial deconvolution, the contrast response in V1 showed a slight local maximum at mid cortical depth, whereas V2 exhibited a monotonic signal increase toward the cortical surface. After applying the deconvolution, both V1 and V2 showed a pronounced local maximum at mid cortical depth, with an additional peak in deep grey matter, especially in V1. Moreover, we found a difference in contrast sensitivity between V1 and V2, but no evidence for variations in contrast sensitivity as a function of cortical depth. These findings are in agreement with results obtained in nonhuman primates, but further research will be needed to validate the spatial deconvolution approach.

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Section: Discussionmentioning

confidence: 99%

Section: Limitations and Directions For Future Researchmentioning

confidence: 99%

Section: Limitations and Directions For Future Researchmentioning

confidence: 99%

See 1 more Smart Citation

Cortical depth profiles of luminance contrast responses in human V1 and V2 using 7 T fMRI

Marquardt

Schneider

Gulban

et al. 2018

Human Brain Mapping

Self Cite

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“…For example, several layer-resolved fMRI studies focused on stimulus-evoked or task associated fMRI responses within a single cortical region found that fMRI signals (BOLD, CBV and CBF) responded differently to the same stimulus across layers of visual and somatosensory cortices (Bandettini, 2012; Goense, et al, 2012; Goense and Logothetis, 2006; Huber, et al, 2015; Huber, et al, 2017; Maier, et al, 2010; Silva and Koretsky, 2002; Tian, et al, 2010). Stimulus evoked BOLD signal changes generally are biased toward upper and middle layer (Poplawsky and Kim, 2014).…”

Section: Discussionmentioning

confidence: 99%

Functional connectivity with cortical depth assessed by resting state fMRI of subregions of S1 in squirrel monkeys

Mishra

Majumdar

Wang

et al. 2018

Human Brain Mapping

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Whereas resting state BOLD (blood oxygenation-level dependent) functional MRI (fMRI) has been widely used to assess functional connectivity between cortical regions, the laminar specificity of such measures is poorly understood. This study aims to determine (a) whether the resting state functional connectivity (rsFC) between two functionally related cortical regions varies with depth, (b) the relationship between layer-resolved tactile stimulus-evoked activation pattern and inter-layer rsFC pattern between two functionally distinct but related areas 3b and 1, and (c) the effects of spatial resolution on rsFC measures. We examined the inter-layer rsFC between somatosensory areas 3b and 1 of squirrel monkeys under anesthesia using tactile stimulus-driven and resting state BOLD acquisitions at sub-millimeter resolution. Consistent with previous observations in the areas 3b and 1, we detected robust stimulus-evoked BOLD activations with foci confined mainly to the upper layers (centered at 21% of the cortical depth). By carefully placing seeds in upper, middle and lower layers of areas 3b and 1, we observed strong rsFC between superficial and middle layers of these two areas. The layer-resolved activation patterns in areas 3b and 1 agree with their inter-layer rsFC patterns, and are consistent with the known anatomical connections between layers. In summary, using BOLD rsFC pattern we identified an inter-layer inter-areal microcircuit that shows strong intrinsic functional connections between superficial and middle layer somatosensory areas 3b and 1 of monkeys. RsFC can be used as a robust invasive tool to probe inter-layer cortico-cortical microcircuits.

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“…Beyond BOLD, the adaptation of single-shot spiral acquisition for other time series readouts seems promising. In particular fMRI modalities with different contrast preparation (Huber et al, 2017b), such as blood-flow sensitive ASL (Detre et al, 2012(Detre et al, , 1992, and blood-volume sensitive VASO (Huber et al, 2018;Lu et al, 2013Lu et al, , 2003 benefit from the shorter TEs offered by spiral-out readouts. These sequences do not rely on T2* decay for functional sensitivity, and thus minimizing TE leads to considerable CNR gains (Cavusoglu et al, 2017;Chang et al, 2017).…”

Section: Translation To Other Fmri Applicationsmentioning

confidence: 99%

Advances in Spiral fMRI: A High-resolution Study with Single-shot Acquisition

Kasper

Engel

Heinzle

et al. 2019

Preprint

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Spiral fMRI has been put forward as a viable alternative to rectilinear echo-planar imaging, in particular due to its enhanced average k-space speed and thus high acquisition efficiency. This renders spirals attractive for contemporary fMRI applications that require high spatiotemporal resolution, such as laminar or columnar fMRI. However, in practice, spiral fMRI is typically hampered by its reduced robustness and ensuing blurring artifacts, which arise from unaccounted imperfections in both static and dynamic magnetic fields.Recently, these limitations have been overcome by the concerted application of an expanded signal model factoring in such field imperfections, and its corresponding inversion by iterative image reconstruction. In the challenging ultra-high field environment of 7 Tesla, where field inhomogeneity effects are aggravated, both multi-shot and single-shot 2D spiral imaging at sub-millimeter resolution was demonstrated with high depiction quality and anatomical congruency.In this work, we further these advances towards a time series application of spiral readouts, namely, single-shot spiral BOLD fMRI at 0.8mm in-plane resolution. We report that spiral fMRI at 7T is feasible, delivering both competitive image quality and BOLD sensitivity, with a spatial specificity of the activation maps that is not compromised by artifactual blurring. Furthermore, we show the versatility of the approach with a combined in/out spiral readout at a more typical resolution (1.5 mm), where the high acquisition efficiency allows to acquire two images per shot for improved sensitivity by echo combination. Advances in Spiral fMRI 3/42 Advances in Spiral fMRI 5/42

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Non-BOLD contrast for laminar fMRI in humans: CBF, CBV, and CMRO2

Cited by 119 publications

References 193 publications

Cortical depth profiles of luminance contrast responses in human V1 and V2 using 7 T fMRI

Cortical depth profiles of luminance contrast responses in human V1 and V2 using 7 T fMRI

Functional connectivity with cortical depth assessed by resting state fMRI of subregions of S1 in squirrel monkeys

Advances in Spiral fMRI: A High-resolution Study with Single-shot Acquisition

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