Non-cancer effects of chronic arsenicosis with special reference to liver damage

Comparative Efficacy of Two Microdoses of a Potentized Homeopathic Drug, Arsenicum Album, to Ameliorate Toxicity Induced by Repeated Sublethal Injections of Arsenic Trioxide in Mice

“…The liver appeared to be one of the major organs in which arsenic caused considerable damage, tissue necrosis and other histological as well as biochemical changes [13][14][15][16][17][18] . Liver damage as a consequence of arsenic poisoning has also been reported in human subjects [29] . The gradual increase in the activities of liver function enzymes like ALT, AST, AcP and AlkP after repeated injections of arsenic trioxide corroborates this view.…”

“…However, the efficacy of Ars Alb 200 has been reported to have ameliorating effect on stray cases of arsenic intoxication in the homeopathic literature (http://www.geocities.com/ drratiram_sharma/). In the orthodox regimen, some antibiotics, chelators and vitamins tested had only a limited success in terms of their ability to remove arsenic from within the body or in their ability to ameliorate arsenicosis [29] . Further, except for vitamins, the other substances had their own toxic effects.…”

Arsenicos is: A Review of Its Diagnosis and Treatment

“…In the moderate variety, the lesions usually advance to form raised, punctate, keratosis, 2-5 mm in diameter . When the keratosis becomes severe, it may form keratotic elevations more than 5 mm in size and sometimes become confluent and diffuse and sometimes result in cracks and fissures too 34,39 [ Fig-6]. Though palms and soles are primarily affected by hyperkeratosis, dorsa of the extremities and trunk may also be affected by it.…”

Inorganic arsenic: a need and an opportunity to improve risk assessment.

“…since 1991 to stu isse relatd to arsenic risk aessment and has held worikhops and in nial o rnces on arsenic The topic of this paper is made time by cunt sdctific in in exure to and aders health effec of arsenic in the United States and pasage of the Safe Drinin Waer Act Amendments of 1996, which has provisions for a reseasch program on arsenic and a schedule mandatig the EPA to revise the maximum contaminant level ofarsec in drinking water by the In selected regions of the world, long-term ingestion of arsenic at relatively high concentrations in drinking water has been associated with disorders of the skin ranging from hyperpigmentation or hypopigmentation and hyperkeratosis to various skin cancers; with cancers of the bladder, liver, lung, kidney, colon, and other internal organs; with peripheral vascular disorder that may include blackfoot disease; and with other confirmed or suspected adverse effects including diabetes, ischemic heart disease, reproductive effects, and impairment of liver function (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Observed toxicity has largely been associated with inorganic arsenic, which is the focus of this paper.…”

“…Thus, nutritional deficiencies may contribute to the high incidence of arsenicinduced human health effects in India and Taiwan (13)(14)(15) For example, the Tseng study (5,6) used in the 1988 EPA risk assessment collected skin cancer data on individuals, but relied on a previous study for exposure data on wells tested for arsenic concentrations. Participants were identified with a village but not with the specific well within the village used for drinking water.…”