Non-Cardiac Chest Pain: The Long-Term Natural History and Comparison With Gastroesophageal Reflux Disease

Williams, J.; Sontag, Stephen J.; Schnell, Thomas; Leya, Jack

doi:10.1038/ajg.2009.279

Cited by 29 publications

(18 citation statements)

References 7 publications

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“…This finding was confirmed by other studies indicating more frequent gastrointestinal complaints in NCCP patients such as sore throat, dysphagia, and regurgitation [12,18]. However, patients with NCCP are not generally different to patients with cardiac chest pain (CCP) with regard to demography and long-term follow-up [8,12,23,24]. Risk factors for NCCP are overweight (odds ratio (OR) 3.0, 95% confidence interval (CI) 1.64-5.50), reflux (OR 2.8, 95% CI 1.73-4.32), smoking (OR 2.0, 95% CI 1.27-3.18), aspirin (OR 1.5, 95% CI 1.00-2.31), non-steroidal anti-inflammatory drugs (OR 2.0, 95% CI 1.27-3.16), neuroticism (OR 1.14, 95% CI 1.08-1.21), and anxiety (OR 1.12, 95% CI 1.08-1.17) [24][25][26].…”

Section: Patient Characteristicssupporting

confidence: 78%

Non-Cardiac Chest Pain

Frieling¹

2018

Visc Med

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Background: Non-cardiac chest pain (NCCP) is recurrent angina pectoris-like pain without evidence of coronary heart disease in conventional diagnostic evaluation. The prevalence of NCCP is up to 70% and may be detected (in this order) at all levels of the medical health care system (general practitioner, emergency department, chest pain unit, coronary care). Reduction of quality of life due to NCCP is comparable, and partially even higher, to that caused by cardiac chest pain. Reasons for psychological strain are symptom recurrence in approximately 50%, nonspecific diagnosis with resulting uncertainty, and insufficient integration of other medical disciplines in the diagnostic workup. Methods and Results: The management of patients with chest pain has to be multidisciplinary because non-cardiac causes may be frequently encountered. Especially gastroenterological expertise is required since the cause of chest pain is gastroesophageal reflux disease (GERD) in 50-60%, hypercontractile esophageal motility disorders with nutcracker/jackhammer esophagus or diffuse esophageal spasm or achalasia in 15-18%, and other esophageal alterations (e.g., infectious esophageal inflammation, drug-induced ulcers, rings, webs, eosinophilic esophagitis) in 32-35%. Conclusion: This review highlights the importance of regular interdisciplinary ward rounds and management of chest pain units.

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Section: Patient Characteristicssupporting

confidence: 78%

Non-Cardiac Chest Pain

Frieling¹

2018

Visc Med

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“…We explored six functional somatic syndromes: CFS, fibromyalgia, irritable bowel syndrome (IBS), non-cardiac chest pain, hyperventilation syndrome, and chronic pain syndrome. Diagnostic algorithms were constructed on the basis of existing clinical and research criteria [33][34][35][36][37] and in accordance with previous studies investigating overlap of several functional somatic syndromes [6,38]. Diagnostic criteria and algorithms for the six functional somatic syndromes are shown in Appendix A.…”

Section: Diagnostic Categoriesmentioning

confidence: 99%

One single diagnosis, bodily distress syndrome, succeeded to capture 10 diagnostic categories of functional somatic syndromes and somatoform disorders

Fink

Schröder

2010

Journal of Psychosomatic Research

280

191

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“…Reflux oesophagitis is one of the oesophageal syndromes in which the condition is accompanied by oesophageal injury 6 . The main symptoms of GERD are heartburn and regurgitation, but other symptoms, such as dysphagia, halitosis, and bloating have also been reported in the literature 7,8 . GERD‐related symptoms are considered troublesome due to their negative effect on the quality of life 6 .…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic measurement of the thickness of cervical oesophagus layers in the reflux oesophagitis: Association with clinical findings

Yalçın

Taydaş

Koç³

et al. 2020

Sonography

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Introduction We aimed to evaluate the oesophagus of patients with reflux oesophagitis using ultrasonography and sought associations between the measurements of the mucosa, submucosa and muscularis propria, and endoscopic and clinical findings. Methods Thirty‐nine patients with endoscopically proven reflux oesophagitis and 19 patients with negative endoscopy for oesophagitis were included in the study. Two radiologists assessed the cervical oesophagus at the level of the thyroid gland. The data belonging to the ultrasonographic assessment of the patient group were compared to those of the controls. Results The muscular, submucosal and mucosal thicknesses of the cervical oesophagus measured by two observers significantly differed between the patient and control groups. The P‐values for mucosa, submucosa and muscularis propria were .02, <.001 and <.001, respectively for observer 1, .004, .001 and <.001, respectively for observer 2. The regression analysis showed that among the symptoms of heartburn, regurgitation and dysphagia, heartburn was independently associated with decreased mucosal and submucosal thicknesses of the oesophagus. Discussion Our findings confirmed that the layers of oesophagus in the gastroesophageal reflux disease were thicker compared to those of healthy people. We also found that heartburn was associated with decreased thicknesses of mucosal and submucosal layers in patients.

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Non-Cardiac Chest Pain: The Long-Term Natural History and Comparison With Gastroesophageal Reflux Disease

Cited by 29 publications

References 7 publications

Non-Cardiac Chest Pain

Non-Cardiac Chest Pain

One single diagnosis, bodily distress syndrome, succeeded to capture 10 diagnostic categories of functional somatic syndromes and somatoform disorders

Ultrasonographic measurement of the thickness of cervical oesophagus layers in the reflux oesophagitis: Association with clinical findings

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