Non-cardiac factors for prediction of response to cardiac resynchronization therapy: The value of baseline, and of serial changes, in red cell distribution width

Carluccio, Erberto; Biagioli, Paolo; Alunni, Gianfranco; Murrone, Adriano; Zingarini, Gianluca; Coiro, Stefano; D’Antonio, Antonella; Mengoni, Anna; Cerasa, Maria Francesca; Ambrosio, Giuseppe

doi:10.1016/j.ijcard.2017.05.123

Cited by 10 publications

(9 citation statements)

References 29 publications

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“…In addition, patients who had atrial fibrillation, pacemaker rhythm (ie, pacemaker, implantable cardioverter‐defibrillator, and cardiac resynchronization therapy), and absence of ventricular premature complex (VPC) were not included because of reliable data analysis. The calculation of RDW was performed based on [standard deviation of red cell volume/mean cell volume] × 100 12 . We then divided the patients (n = 222) into two groups based on their RDW levels: high RDW group (>14.5%, n = 92) and low RDW group (≤14.5%, n = 130) as described in a previous study 12 .…”

Section: Methodsmentioning

confidence: 99%

“…The calculation of RDW was performed based on [standard deviation of red cell volume/mean cell volume] × 100 12 . We then divided the patients (n = 222) into two groups based on their RDW levels: high RDW group (>14.5%, n = 92) and low RDW group (≤14.5%, n = 130) as described in a previous study 12 . We investigated the relation of RDW levels to cardiac autonomic function, assessed using Holter recordings, and clinical outcomes.…”

Section: Methodsmentioning

confidence: 99%

“…3 High levels of RDW may be correlated with mortality in patients with heart failure. 3,12 However, the exact roles of RDW in heart failure as a cause of cardiac events remain unclear.…”

Section: Rdw and Cardiac Events In Heart Failurementioning

confidence: 99%

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The relationship between red cell distribution width and cardiac autonomic function in heart failure

Yamada

Yoshihisa

Kaneshiro

et al. 2020

Journal of Arrhythmia

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Background Both increases in red cell distribution width (RDW) levels and autonomic dysfunction are considered to be correlated with worsening heart failure. However, the relation of RDW levels to autonomic function remains uncertain. We aimed to investigate the association of RDW levels in heart failure with autonomic function, evaluated by heart rate variability (HRV) and heart rate turbulence (HRT), and prognosis. Methods We studied 222 hospitalized patients with stable heart failure before discharge, and Holter recordings (HRV and HRT) were performed. Additionally, RDW levels were measured, and high RDW was defined as over 14.5%. We then divided the patients into two groups based on RDW levels: high RDW group (>14.5%, n = 92) and low RDW group (≤14.5%, n = 130). The relation of RDW to autonomic function and prognosis was assessed. Results In the high RDW group, severely impaired HRV and HRT were found compared to the low RDW group. In the linear regression analysis after the adjustment of multiple confounders, RDW levels were correlated with a low‐frequency (LF) to high‐frequency (HF) ratio and very low‐frequency (VLF) power (LF to HF ratio, β = −0.146, P = .027, and VLF power, β = −0.137, P = .041, respectively). During the observation period (median 1400 days), cardiac events (re‐hospitalization of heart failure, cardiac death or sudden death) were found in 73 (32.8%) patients. The Kaplan‐Meier analysis demonstrated that the high RDW group had a higher rate of cardiac events compared to the low RDW group (45.6% vs 23.8%, log‐rank P < .001). Conclusion High RDW levels were correlated with autonomic dysfunction, resulting in poor clinical outcomes.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The relationship between red cell distribution width and cardiac autonomic function in heart failure

Yamada

Yoshihisa

Kaneshiro

et al. 2020

Journal of Arrhythmia

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“…It was found that increased and stable-high RDW levels were associated with both LV remodelling and outcome after CRT. However, RDW did not have any incremental predictive role 17 . Moreover, Topaz et al .…”

Section: Discussionmentioning

confidence: 71%

“…The role of baseline RDW and its serial changes after CRT implant remains unknown. In a cohort of 148 patients RDW levels were measured before and 3 months after CRT implant 17 . It was found that increased and stable-high RDW levels were associated with both LV remodelling and outcome after CRT.…”

Section: Discussionmentioning

confidence: 99%

Full blood count as potential predictor of outcomes in patients undergoing cardiac resynchronization therapy

Papageorgiou

Falconer

Wongwarawipat

et al. 2019

Sci Rep

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Almost a third of patients fulfilling current guidelines criteria have suboptimal responses following cardiac resynchronization therapy (CRT). Circulating biomarkers may help identify these patients. We aimed to assess the predictive role of full blood count (FBC) parameters in prognosis of heart failure (HF) patients undergoing CRT device implantation. We enrolled 612 consecutive CRT patients and FBC was measured within 24 hours prior to implantation. The follow-up period was a median of 1652 days (IQR: 837–2612). The study endpoints were i) composite of all-cause mortality or transplant, and ii) reverse left ventricular (LV) remodeling. On multivariate analysis [hazard ratio (HR), 95% confidence interval (CI)] only red cell count (RCC) (p = 0.004), red cell distribution width (RDW) (p < 0.001), percentage of lymphocytes (p = 0.03) and platelet count (p < 0.001) predicted all-cause mortality. Interestingly, RDW (p = 0.004) and platelet count (p = 0.008) were independent predictors of reverse LV remodeling. This is the first powered single-centre study to demonstrate that RDW and platelet count are independent predictors of long-term all-cause mortality and/or heart transplant in CRT patients. Further studies, on the role of these parameters in enhancing patient selection for CRT implantation should be conducted to confirm our findings.

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Clinical outcome of left ventricular multipoint pacing versus conventional biventricular pacing in cardiac resynchronization therapy: a systematic review and meta-analysis

Zheng

Ding

et al. 2018

Heart Fail Rev

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Cardiac resynchronization therapy (CRT) is an effective treatment for selected patients with systolic heart failure. Unlike conventional biventricular pacing (BIP), the left ventricular multipoint pacing (MPP) can increase the number of left ventricular pacing sites via a quadripolar lead positioned in the coronary sinus. This synthetic study was conducted to integratively and quantitatively evaluate the clinical outcome of MPP in comparison with BIP. We systematically searched the databases of EMBASE, Ovid medline, and Cochrane Library through May 2018 for studies comparing the clinical outcome of MPP with BIP in the patients who accepted CRT. Hospitalization for reason of heart failure, left ventricular eject fraction (LVEF), CRT response, all-cause morbidity, and cardiovascular death rate was collected for meta-analysis. A total of 11 studies with 29,606 participants were included in this meta-analysis. Compared with BIP group, MPP decreased heart failure hospitalization (OR, 0.41; 95% CI, 0.33 to 0.50; P < 0.00001), improved LVEF (mean difference, 4.97; 95% CI, 3.11 to 6.83; P < 0.00001), increased CRT response (OR, 3.64; 95% CI, 1.68 to 7.87; P = 0.001), and decreased all-cause morbidity (OR, 0.41; 95% CI, 0.26-0.66; P = 0.0002) and cardiovascular death rate (OR, 0.21; 95% CI, 0.11-0.40; P < 0.00001). The published literature demonstrates that MPP was more effective than BIP in the heart failure patients who accepted cardiac resynchronization therapy.

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Non-cardiac factors for prediction of response to cardiac resynchronization therapy: The value of baseline, and of serial changes, in red cell distribution width

Cited by 10 publications

References 29 publications

The relationship between red cell distribution width and cardiac autonomic function in heart failure

The relationship between red cell distribution width and cardiac autonomic function in heart failure

Full blood count as potential predictor of outcomes in patients undergoing cardiac resynchronization therapy

Clinical outcome of left ventricular multipoint pacing versus conventional biventricular pacing in cardiac resynchronization therapy: a systematic review and meta-analysis

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