Non-cephalic reference recording of early somatosensory potentials to finger stimulation in adult or aging normal: differentiation of widespread N18 and contralateral N20 from the prerolandic p22 and N30 components

Desmedt, Jean Edouard; Chéron, Guy

doi:10.1016/0013-4694(81)91430-9

Cited by 372 publications

(105 citation statements)

References 28 publications

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“…The N20 component reflects the initial response of area 3b in somatosensory cortex (Allison, 1982), and increases in amplitude in older subjects compared to young subjects (Desmedt and Cheron, 1981). Our results suggest that additional increases of N20 amplitude in untreated MCI can accompany early cognitive decline affecting memory functions.…”

Section: Somatosensory Potentials In Mild Cognitive Impairment and Chmentioning

confidence: 63%

“…Our results suggest that additional increases of N20 amplitude in untreated MCI can accompany early cognitive decline affecting memory functions. It is unlikely that the N20 amplitude changes found in both older control subjects (Desmedt and Cheron, 1981) and our untreated MCI subjects were due to peripheral nerve disorders that are common in aging. If anything, peripheral nerve disorders are associated with decreased N20 amplitude (Desmedt and Cheron, 1980).…”

Section: Somatosensory Potentials In Mild Cognitive Impairment and Chmentioning

confidence: 85%

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Cholinesterase inhibitors affect brain potentials in amnestic mild cognitive impairment

et al. 2007

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Amnestic mild cognitive impairment (MCI) is an isolated episodic memory disorder that hasa high likelihood of progressing to Alzheimer's disease. Auditory sensory cortical responses (P50, N100) have been shown to be increased in amplitude in MCI compared to older controls. We tested whether (1) cortical potentials to other sensory modalities (somatosensory and visual) were also affected in MCI and (2) cholinesterase inhibitors (ChEIs), one of the therapies used in this disorder, modulated sensory cortical potentials in MCI. Somatosensory cortical potentials to median nerve stimulation and visual cortical potentials to reversing checkerboard stimulation were recorded from 15 older controls and 15 amnestic MCI subjects (single domain). Results were analyzed as a function of diagnosis (Control, MCI) and ChEIs treatment (Treated MCI, Untreated MCI). Somatosensory and visual potentials did not differ significantly in amplitude in MCI subjects compared to controls.When ChEIs use was considered, somatosensory potentials (N20, P50) but not visual potentials (N70, P100, N150) were of larger amplitude in untreated MCI subjects compared to treated MCI subjects. Three individual MCI subjects showed increased N20 amplitude while off ChEIs compared to while on ChEIs. An enhancement of N20 somatosensory cortical activity occurs in amnestic single-domain MCI and is sensitive to modulation by ChEIs. IntroductionMild cognitive impairment (MCI) describes older individuals having cognitive impairments without accompanying functional impairments that characterize dementia (Petersen et al., 1999). Recent studies have suggested criteria for distinguishing among four subtypes of MCI based on the presence of both episodic memory impairment (amnestic or non-amnestic MCI) and other cognitive impairments (single-or multipledomain MCI) (Petersen, 2004). For example, amnestic singledomain MCI refers to patients with involvement of only memory deficit whereas amnestic multiple-domain MCI refers to patients with impairment of both memory and other cognitive domains such as language or executive function. MCI subjects have a high risk of converting to Alzheimer's disease Petersen et al., 1999) and show neuropathological features of β-amyloid plaques and neurofibrillary tangles similar to early Alzheimer's disease (Kordower et al., 2001;Mufson et al., 1999). These findings suggest that MCI can be a precursor of Alzheimer's disease. Cholinergic processes in neocortical areas are affected in Alzheimer's disease (Geula and Mesulam, 1989;Heckers et al., 1992) and are particularly apparent late in the course of

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Section: Somatosensory Potentials In Mild Cognitive Impairment and Chmentioning

confidence: 63%

Section: Somatosensory Potentials In Mild Cognitive Impairment and Chmentioning

confidence: 85%

Cholinesterase inhibitors affect brain potentials in amnestic mild cognitive impairment

et al. 2007

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“…For the source reconstruction, we focused on the N20 wave because its source has been previously shown to be located in the primary sensory cortex (Desmedt and Cheron, 1981). We used a time window extending from 20 to 25 ms around the N20 peak (at 23 ms).…”

Section: Real Source Reconstructionmentioning

confidence: 99%

An empirical Bayesian solution to the source reconstruction problem in EEG

et al. 2005

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Distributed linear solutions of the EEG source localisation problem are used routinely. In contrast to discrete dipole equivalent models, distributed linear solutions do not assume a fixed number of active sources and rest on a discretised fully 3D representation of the electrical activity of the brain. The ensuing inverse problem is underdetermined and constraints or priors are required to ensure the uniqueness of the solution. In a Bayesian framework, the conditional expectation of the source distribution, given the data, is attained by carefully balancing the minimisation of the residuals induced by noise and the improbability of the estimates as determined by their priors. This balance is specified by hyperparameters that control the relative importance of fitting and conforming to various constraints. Here we formulate the conventional bWeighted Minimum NormQ (WMN) solution in terms of hierarchical linear models. An bExpectation-MaximisationQ (EM) algorithm is used to obtain a bRestricted Maximum LikelihoodQ (ReML) estimate of the hyperparameters, before estimating the bMaximum a PosterioriQ solution itself. This procedure can be considered a generalisation of previous work that encompasses multiple constraints. Our approach was compared with the bclassicQ WMN and Maximum Smoothness solutions, using a simplified 2D source model with synthetic noisy data. The ReML solution was assessed with four types of source location priors: no priors, accurate priors, inaccurate priors, and both accurate and inaccurate priors. The ReML approach proved useful as: (1) The regularisation (or influence of the a priori source covariance) increased as the noise level increased. (2) The localisation error (LE) was negligible when accurate location priors were used. (3) When accurate and inaccurate location priors were used simultaneously, the solution was not influenced by the inaccurate priors. The ReML solution was then applied to real somatosensory-evoked responses to illustrate the application in an empirical setting. D

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“…The N13 SEP peak is reflective of the activity of the interneurons within the dorsal horn and midcervical cord (Desmedt and Cheron 1981;Sonoo et al 1991). While there were increases in amplitude for both tracing and typing postacquisition, the change was larger for the tracing group and the interaction was only seen between control and tracing.…”

mentioning

confidence: 95%

Do pursuit movement tasks lead to differential changes in early somatosensory evoked potentials related to motor learning compared with typing tasks?

Andrew

Yielder

Murphy

2015

Journal of Neurophysiology

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Andrew D, Yielder P, Murphy B. Do pursuit movement tasks lead to differential changes in early somatosensory evoked potentials related to motor learning compared with typing tasks ? J Neurophysiol 113: 1156 -1164, 2015. First published November 26, 2014 doi:10.1152/jn.00713.2014.-Central nervous system (CNS) plasticity is essential for development; however, recent research has demonstrated its role in pathology, particularly following overuse and repetition. Previous studies investigating changes in sensorimotor integration (SMI) have used relatively simple paradigms resulting in minimal changes in neural activity, as determined through the use of somatosensory evoked potentials (SEPs). This study sought to utilize complex tasks and compare separate motor paradigms to determine which one best facilitates long-term learning. Spinal, brainstem, and cortical SEPs were recorded following median nerve stimulation at the wrist pre-and postinterventions. Eighteen participants performed the same paradigms, a control condition of 10 min of mental recitation and two interventions, one consisting of 10 min of tracing and the other 10 min of repetitive typing. Significant increases in the N13, N20, P25, and N30 SEP peaks were seen for both interventions. A significant decrease in the N24 SEP peak was observed for both interventions. Significant improvements in accuracy were seen for both interventions postacquisition but only for tracing during retention. The changes seen following motor learning were congruent with those associated with long-term learning, which was also reflected by significant increases in accuracy during retention. Tracing or the pursuit movement paradigm was shown to be a more effective learning tool. The identification of a task that is sufficiently novel and complex, leading to robust changes in SEP peaks, indicates a task that can be utilized in future work to study clinical populations and the effect of experimental interventions on SMI.

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Non-cephalic reference recording of early somatosensory potentials to finger stimulation in adult or aging normal: differentiation of widespread N18 and contralateral N20 from the prerolandic p22 and N30 components

Cited by 372 publications

References 28 publications

Cholinesterase inhibitors affect brain potentials in amnestic mild cognitive impairment

Cholinesterase inhibitors affect brain potentials in amnestic mild cognitive impairment

An empirical Bayesian solution to the source reconstruction problem in EEG

Do pursuit movement tasks lead to differential changes in early somatosensory evoked potentials related to motor learning compared with typing tasks?

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