Non-Ceruloplasmin Copper Distincts Subtypes in Alzheimer’s Disease: a Genetic Study of ATP7B Frequency

Squitti, Rosanna; Ventriglia, Mariacarla; Gennarelli, Massimo; Colabufo, Nicola Antonio; Idrissi, Imane Ghafir El; Bucossi, Serena; Mariani, Stefania; Rongioletti, Mauro; Zanetti, Orazio; Congiu, Chiara; Rossini, Paolo Maria; Bonvicini, Cristian

doi:10.1007/s12035-015-9664-6

Cited by 39 publications

(23 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we deem this not to be a valid reason for abandoning therapeutic chelation of copper ions in AD that has not been yet thoroughly tested. In our opinion, anti-copper therapies appear to have excellent chances to affect positively the condition for a percentage of AD patients, in agreement with the notion of the existence of different AD “sub-types” ( 32 – 35 ).…”

supporting

confidence: 87%

Commentary: The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer’s Disease

et al. 2017

Self Cite

View full text Add to dashboard Cite

supporting

confidence: 87%

Commentary: The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer’s Disease

et al. 2017

Self Cite

View full text Add to dashboard Cite

“…Another earlier research also observed an increased concentration of serum copper ions in a special kind of AD (Alzheimer’s disease epsilon four apolipoprotein E allele carriers) [ 237 ]. According to some scientific investigation, a genetic basis may be the reason for this particular type of AD [ 237 , 238 , 239 , 240 ].…”

Section: Contradictory Results About Copper Level In Admentioning

confidence: 99%

Copper Toxicity Links to Pathogenesis of Alzheimer’s Disease and Therapeutics Approaches

Ejaz

Wang

Lang

2020

IJMS

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is an irreversible, age-related progressive neurological disorder, and the most common type of dementia in aged people. Neuropathological lesions of AD are neurofibrillary tangles (NFTs), and senile plaques comprise the accumulated amyloid-beta (Aβ), loaded with metal ions including Cu, Fe, or Zn. Some reports have identified metal dyshomeostasis as a neurotoxic factor of AD, among which Cu ions seem to be a central cationic metal in the formation of plaque and soluble oligomers, and have an essential role in the AD pathology. Cu-Aβ complex catalyzes the generation of reactive oxygen species (ROS) and results in oxidative damage. Several studies have indicated that oxidative stress plays a crucial role in the pathogenesis of AD. The connection of copper levels in AD is still ambiguous, as some researches indicate a Cu deficiency, while others show its higher content in AD, and therefore there is a need to increase and decrease its levels in animal models, respectively, to study which one is the cause. For more than twenty years, many in vitro studies have been devoted to identifying metals’ roles in Aβ accumulation, oxidative damage, and neurotoxicity. Towards the end, a short review of the modern therapeutic approach in chelation therapy, with the main focus on Cu ions, is discussed. Despite the lack of strong proofs of clinical advantage so far, the conjecture that using a therapeutic metal chelator is an effective strategy for AD remains popular. However, some recent reports of genetic-regulating copper transporters in AD models have shed light on treating this refractory disease. This review aims to succinctly present a better understanding of Cu ions’ current status in several AD features, and some conflicting reports are present herein.

show abstract

“…A subgroup of patients with Alzheimer disease has some evidence for copper toxicity . Of particular interest, the ATP7B ‐K832R and ‐R952K polymorphisms appear to be Alzheimer disease susceptibility alleles . If this association proves to be correct, some forms of dementia may be late symptoms of WD.…”

Section: Discussionmentioning

confidence: 99%

“…(45) Of particular interest, the ATP7B-K832R and -R952K polymorphisms appear to be Alzheimer disease susceptibility alleles. (46,47) If this association proves to be correct, some forms of dementia may be late symptoms of WD. These observations raise several important questions regarding the initial and long-term management of patients.…”

Section: Discussionmentioning

confidence: 99%

Age and Sex but Not ATP7B Genotype Effectively Influence the Clinical Phenotype of Wilson Disease

Stremmel²,

et al. 2019

View full text Add to dashboard Cite

show abstract

Non-Ceruloplasmin Copper Distincts Subtypes in Alzheimer’s Disease: a Genetic Study of ATP7B Frequency

Cited by 39 publications

References 56 publications

Commentary: The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer’s Disease

Commentary: The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer’s Disease

Copper Toxicity Links to Pathogenesis of Alzheimer’s Disease and Therapeutics Approaches

Age and Sex but Not ATP7B Genotype Effectively Influence the Clinical Phenotype of Wilson Disease

Contact Info

Product

Resources

About