Non-chewable antacid formulations: Effect of different disintegrating agents on their acid Neutralization properties

Abstract

Aim of the present work is to develop non-chewable antacid tablets using different disintegrating agents viz., microcrystalline cellulose, sodium starch glycolate (Primogel®), and cross-linked sodium carboxymethylcellulose (cros-car-mellose sodium®). These agents were used alone, and in combinations, both 50% intra-granularly, and 50% extra-granularly. To cover all these variables in the formulations, seven different formulations were designed. Use of different disintegrating agents have shown varying effect on disintegration time and pattern. The disintegration time for formulation I and III did not comply with the official disintegration test in distilled water, as well as in simulated gastric fluid. All formulations, except formulation I and III, showed nearly equivalent to 30 min of Rosset-Rice time for neutralization. The graphical representation shows that when the base is available in full strength, it neutralizes the acid at a faster rate, and then the amount of base goes on reducing progressively, resulting in decrease in the rate of neutralization. Based on't' values, formulation II and VI show that the theoretical acid-consuming capacity, and the observed acid-consuming capacity values are almost equal.

Evaluation of cost effectiveness and efficacy of commonly used different antacid gel preparations

“…Amount of acid consumed per gram of antacid was expressed in terms of mEq. 6,14 Practical mEq= ( The palatability test was conducted on healthy volunteers. The highest palatable score obtained was 26.80 for antacid A3 and the lowest score was 23.85 for antacid A5.…”

“…Several studies have been undertaken to determine palatability and in vitro efficacy of OCT antacid brands. 6,14 In our study we have assessed the cost effectiveness and acid neutralizing capacity of various gel formulations of antacids.…”

Formulatiom, Preparation and Evaluation of Mouth Disintegrating Tablet of Ranitidine HCl and Domperidone

“…This is made up of a plastic drum fixed with a machine which rotated at 25 rpm for 100 revolutions. Then the twenty tablets which were weighed prior to the test are taken out of the drum and cleaned with a cloth and weighed once again, the weight variation must not be less than 0.5 to 1.0 % for a conventional tablet 10,11 .…”