Non-chiral Polymer-induced Chirality Enhancement in Lipidic Nanotube-based Hydrogel System

Robel, Fataha Nur; Takafuji, Makoto; Ihara, Hirotaka

doi:10.1246/cl.170586

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…We previously reported self-assembled supramolecular hydrogels with cross-linked networks (hetero-network hydrogels), in which the polymer chains are linked with nanobrous aggregates. 16,17 In all such self-assembled cross-linked polymer hydrogels, the crosslinking points are formed by the insertion of hydrophobic groups such as cholesterol and long alkyl chains into the hydrophobic region of the self-assembly. The healing properties of such hydrogels originate from the co-aggregation of hydrophobic groups and self-assembling molecules.…”

Section: Introductionmentioning

confidence: 99%

Nanofibrous chiral supramolecular assembly-derived self-healing hydrogels with polyethylene glycol

Takafuji,

Kawamoto,

Hano

et al. 2024

Nanoscale Adv.

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Section: Introductionmentioning

confidence: 99%

Nanofibrous chiral supramolecular assembly-derived self-healing hydrogels with polyethylene glycol

Takafuji,

Kawamoto,

Hano

et al. 2024

Nanoscale Adv.

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“…Not only that, chiral self‐assembly of biological substances has been also applied to fabricate various well‐ordered nanostructures, such as helical nanotubes, [ 17–20 ] nanobelts, [ 21 ] and nanofibers, [ 22,23 ] based on non‐covalent interactions. The chiral self‐organization of small peptides, [ 24–27 ] especially the dipeptide‐based nanotube, has been synthesized.…”

Section: Introductionmentioning

confidence: 99%

“…polarized light, [8][9][10] mechanical forces, [5,[11][12][13][14][15] could trigger a spontaneous symmetry breaking process towards a deterministic enantioselection, instead of adopting a stochastic process when no external force is applied. [3,7,16] Not only that, chiral self-assembly of biological substances has been also applied to fabricate various well-ordered nanostructures, such as helical nanotubes, [17][18][19][20] nanobelts, [21] and nanofibers, [22,23] based on noncovalent interactions. The chiral self-organization of small peptides, [24][25][26][27] especially the dipeptide-based nanotube, has been synthesized.…”

mentioning

confidence: 99%

Kinetic Controlled Chirality Transfer and Induction in 2D Hydrogen‐Bonding Assemblies of Glycylglycine on Au(111)

Zhang

Ding

Shu

et al. 2023

Small

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systems, such as the transfer and storage of genetic information in nucleic acids and the folding of proteins, while its origin remains as a major mystery. [1] For example, proteins are solely composed by l-amino acids, and nucleic acids (DNA and RNAs) are comprised of d-sugars. On the other hand, the chiral symmetry breaking process leads to many compelling observations in supramolecular chemistry, showing the spontaneous emerging of an enantiomeric entity by chiral self-assembly from an achiral molecule or the crystallization with a chiral space group. [2][3][4][5][6][7] More intriguingly, external physical stimulations, e.g. polarized light, [8][9][10] mechanical forces, [5,[11][12][13][14][15] could trigger a spontaneous symmetry breaking process towards a deterministic enantioselection, instead of adopting a stochastic process when no external force is applied. [3,7,16] Not only that, chiral self-assembly of biological substances has been also applied to fabricate various well-ordered nanostructures, such as helical nanotubes, [17][18][19][20] nanobelts, [21] and nanofibers, [22,23] based on noncovalent interactions. The chiral self-organization of small peptides, [24][25][26][27] especially the dipeptide-based nanotube, has been synthesized. [28] The dipeptides are excellent motifs in the fabrication of highly ordered biological structures owing to ease Chirality transfer is of vital importance that dominates the structure and functionality of biological systems and living matters. External physical stimulations, e.g. polarized light and mechanical forces, can trigger the chirality symmetry breaking, leading to the appearance of the enantiomeric entities created from a chiral self-assembly of achiral molecule. Here, several 2D assemblies with different chirality, synthesized on Au(111) surface by using achiral building blocks -glycylglycine (digly), the simplest polypeptide are reported. By delicately tuning the kinetic factors, i.e., one-step slow/rapid deposition, or stepwise slow deposition with mild annealing, achiral square hydrogen-bond organic frameworks (HOF), homochiral rhombic HOF and racemic rectangular assembly are achieved, respectively. Chirality induction and related symmetry broken in assemblies are introduced by the handedness (H-bond configurations in principle) of the assembled motifs and then amplified to the entire assemblies via the interaction between motifs. The results show that the chirality transfer and induction of biological assemblies can be tuned by altering the kinetic factors instead of applying external forces, which may offer an in-depth understanding and practical approach to peptide chiral assembly on the surfaces and can further facilitate the design of desired complex biomolecular superstructures.

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Self‐Assembly of 1D Helical Nanostructures into Higher Order Chiral Nanostructures in Supramolecular Systems

2018

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Chirality and hierarchy are two important aspects of biological systems. Investigation of the hierarchical self‐assembly of chiral supramolecular nanostructures leads not only to biomimics but also provides deep understanding of the self‐assembly and function in biological systems. While it is generally well‐known how small molecules can self‐assemble into nanostructures like chiral nanofibers, nanobelts, nanotubes and nanotwists, it is still less frequently investigated how these nanostructures can be further assembled into higher ordered chiral nanostructures. In this review, we mainly focus on how these 1D helical nanostructure can be further assembled into higher ordered or complex chiral nano/microstructures such as nanospirals, super‐nanohelices, helical nanotubes, nanoflowers, toroids, microflowers, microtubular flowers and dendritic chiral nanotwists. Moreover, some applications including asymmetric catalysis, cell adhesion, chiral optics and chiral recognition based on these nanostructures are discussed.

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Non-chiral Polymer-induced Chirality Enhancement in Lipidic Nanotube-based Hydrogel System

Cited by 5 publications

References 44 publications

Nanofibrous chiral supramolecular assembly-derived self-healing hydrogels with polyethylene glycol

Nanofibrous chiral supramolecular assembly-derived self-healing hydrogels with polyethylene glycol

Kinetic Controlled Chirality Transfer and Induction in 2D Hydrogen‐Bonding Assemblies of Glycylglycine on Au(111)

Self‐Assembly of 1D Helical Nanostructures into Higher Order Chiral Nanostructures in Supramolecular Systems

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