Non-chromaffin Paragangliomatosis Manifesting as a Cold Thyroid Nodule

Haegert, David G.; Wang, N. S.; Farrer, Paul A.; Seemayer, Thomas A.; Thelmo, William

doi:10.1093/ajcp/61.4.561

Cited by 39 publications

(27 citation statements)

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“…This opens avenues for genetic family screening and preventive medicine. Patients with germline mutations of the SDHB gene, as found in two of our patients, may display adrenal, retroperitoneal, pelvic, or thoracic paragangliomas or metachronous head and neck paragangliomas such as carotid glomus tumors (Haegert et al 1974, Hughes et al 1997, which may become malignant and therefore have to undergo lifelong highrisk clinical surveillance (Neumann et al 2004). Similar risk profiles will be identified once a statistically significant number of patients with mutations of the SDHA gene are available.…”

Section: Discussionsupporting

confidence: 57%

A registry-based study of thyroid paraganglioma: histological and genetic characteristics

Dobschuetz

Leijon

Schalin‐Jäntti

et al. 2015

Endocrine-Related Cancer

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Section: Discussionsupporting

confidence: 57%

A registry-based study of thyroid paraganglioma: histological and genetic characteristics

Dobschuetz

Leijon

Schalin‐Jäntti

et al. 2015

Endocrine-Related Cancer

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“…Possibly due to the rarity and unexpected occurrence in the thyroid gland, this tumor type has remained underrecognized. A comprehensive search of the PubMed showed that only 35 cases have been reported in the English literature [1][2][3][4][5]. To better understand this rare entity, we undertook a brief review of the existing literature.…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, most patients presented with an asymptomatic neck mass. In 2 cases, thyroid paraganglioma was associated with synchronous carotid body paraganglioma [3,23,29]. In another case, the tumor was accompanied with papillary thyroid carcinoma, parathyroid adenoma and bilateral carotid body paragangliomas [6].…”

Section: Discussionmentioning

confidence: 99%

“…Occasionally, it may involve unusual sites where paraganglia are not normally distributed. Paraganglioma manifesting as a primary thyroid lesion is extremely rare, comprising less than 0.1 % of all thyroid neoplasms [3]. Due to the unexpected occurrence and overlapping features, thyroid paraganglioma is frequently misdiagnosed as other common types of thyroid neoplasms, which may result in inappropriate treatment.…”

Section: Introductionmentioning

confidence: 99%

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Primary Paraganglioma of Thyroid Gland: A Clinicopathologic and Immunohistochemical Analysis of Three Cases with a Review of the Literature

Wei

Wang

2013

Head and Neck Pathol

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Thyroid paraganglioma is an extremely rare tumor and frequently mistaken for other thyroid neoplasms. Increased awareness of its potential presentation in thyroid and its characteristic features is essential for avoiding diagnostic and therapeutic pitfalls. We describe here three additional cases of primary thyroid paraganglioma and analyze their clinical findings and pathological characteristics. Patients included two women and one man presenting with asymptomatic thyroid nodules. Radiological examinations were nonspecific and none had been diagnosed correctly before surgery. On intraoperative frozen section consultation they were all misdiagnosed as carcinomas, either primary or metastatic. However, the permanent sections showed features consistent with paraganglioma. Of note, two cases displayed extension into adjacent thyroid tissues, one of which exhibited increased mitotic activity, confluent tumor necrosis and vascular invasion. Immunohistochemically, the neoplastic chief cells expressed chromogranin, synaptophysin, neuron-specific enolase and CD56, whereas the sustentacular cells were highlighted by S100 protein. All three patients were well with normal hormone secretion, without local recurrence or distant metastasis at last follow-up (range 10-47 months). We further reviewed the literature to summarize the characteristics of this distinctive entity. Albeit being very rare, paraganglioma should be included in the differential diagnosis of hypervascular thyroidal neoplasms. Accurate diagnosis relies on the histopathogical findings and adjunctive immunohistochemcial studies. To date, all the reported cases have pursued a benign course. Although atypical features seem to have no association with clinical behavior, long time postoperative surveillance with biochemical screening of hormone secretion, cervical ultrasonography and whole-body CT scan is recommended.

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“…24 These paragangliomas rarely may also coexist with paragangliomas in other locations, basically those located unilaterally or bilaterally on the carotid body. 2,8,18,19,24 In the reviews performed by Barnes 2 and Ferlito, 8 only the existence of a functional superior laryngeal paraganglioma is considered. 41 …”

Section: Family Association and Association With Other Tumors Multicmentioning

confidence: 99%

Relapsing paraganglioma of the inferior laryngeal paraganglion: Case report and review of the literature

et al. 2001

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Non-chromaffin Paragangliomatosis Manifesting as a Cold Thyroid Nodule

Cited by 39 publications

References 0 publications

A registry-based study of thyroid paraganglioma: histological and genetic characteristics

A registry-based study of thyroid paraganglioma: histological and genetic characteristics

Primary Paraganglioma of Thyroid Gland: A Clinicopathologic and Immunohistochemical Analysis of Three Cases with a Review of the Literature

Relapsing paraganglioma of the inferior laryngeal paraganglion: Case report and review of the literature

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