Non-cirrhotic Non-Wilsonian degeneration in antiphospholipid syndrome: Association or chance

Kumar, Sunil; Hepat, Sanyukta; Acharya, Sourya; Agrawal, Sachin; Kota, Vijay

doi:10.25259/jnrp-2022-5-9

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2023

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“…In its basic pathophysiology, it contrasts with Wilson's disease. According to a theory, portosystemic shunts and liver detoxification failure make the basal ganglia more susceptible to manganese accumulation, which causes AHD; it appears in 0.8-2% of cirrhotic patients [2,3]. Hepatic encephalopathy (HE), a catastrophic complication of cirrhosis and portosystemic shunts, can cause neuropsychiatric symptoms varying from disorientation to coma and can substantially shorten the lifespans of patients.…”

Section: Introductionmentioning

confidence: 99%

Acquired Parkinson’s Disease in Alcoholic Cirrhosis: The Rarest Association

Dubey¹,

Kumar²,

Acharya³

et al. 2023

Cureus

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Hepatic encephalopathy is the most common neurologic complication of liver cirrhosis, whereas acquired hepatocerebral degeneration (AHD) is an underappreciated neurologic manifestation. Parkinsonism, ataxia, and neuropsychiatric symptoms are its defining characteristics. In individuals with chronic parenchymal liver disease with portosystemic shunting, it is an underrecognized etiology of psychomotor retardation. It has been hypothesized that the etiology of AHD is due to manganese buildup in the basal ganglia. This case report details a hepatocerebral degeneration (AHD) case in a patient with chronic parenchymal liver disease who improved after taking a dopamine agonist.

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Section: Introductionmentioning

confidence: 99%