Non-cirrhotic portal fibrosis related end stage liver disease in adults: evaluation from a study on living donor liver transplant recipients

Abstract

The study concludes that in our population, NCPF constitutes about 5% of the subset of end stage CLD considered eligible for liver transplantation (LT), presenting mostly as cryptogenic cirrhosis (CC). A diagnosis of NCPF should be considered when patients presumed to have cryptogenic or other cirrhosis become eligible for LT even in the presence of relatively well-preserved liver function and low MELD scores. End stage CLD manifests at earlier age, when cirrhosis of another etiology supervenes on pre-existent NCPF.

Noncirrhotic portal fibrosis: a rare cause of end-stage liver disease requiring liver transplantation

“…The study in this issue of Hepatology International shows that small fraction of patients (*5%) do develop ascites, jaundice, and hepatic encephalopathy making it difficult to differentiate it from cirrhosis of liver [17]. Another interesting observation of this study is the overlap NCPF group which has features of both NCPF and cirrhosis and was not reported earlier.…”

Etiologic types of end-stage chronic liver disease in adults

“…In four cases of HCV-related CLD and four cases of NAFLD-related CLD, vascular changes in NCPF as mentioned above were detected randomly in the histologic preparations of the explant livers on which the HCV-induced and NAFLD-induced cirrhotic features had 'overlapped', respectively. The detailed clinical and morphologic features of these two categories of cases referred to as 'pure NCPF' and 'overlap NCPF', respectively, have recently been reported by us separately [30,31]. In cases of overlap NCPF, established cirrhotic changes because of identifiable causes such as HCV or NAFLD had been superimposed on pre-existing morphologic changes [30,31].…”

Natural History of Non Cirrhotic Portal Fibrosis - a Tropical Experience

“…These patients terminally, developed ascites, jaundice, and hepatic encephalopathy making it difficult at times to differentiate this from end stage liver disease due to cirrhosis [31]. Ten patients with hepatitis C (5 patients), hepatitis B (one patient) or non alcoholic fatty liver disease (4 patients) had characteristic portal vein changes.…”