Non-classical effects of vitamin D

Ваниковна, Егшатян Лилит

doi:10.14341/omet2018112-18

Obes. metabol.

2018

DOI: 10.14341/omet2018112-18

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Non-classical effects of vitamin D

Егшатян Лилит Ваниковна¹

Abstract: 1ФГБУ "Национальный медицинский исследовательский центр эндокринологии" Минздрава России, г. Москва 2 ГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова», г. Москва Существуют данные об участии витамина D в модуляции воспалительной реакции и развитии сахарного диабета. Поскольку активация провоспалительных биомаркеров и цитокинов препятствует нормальному обмену веществ и нарушает синтез инсулина и чувствительность тканей к нему, предполагается, что витамин D может влия… Show more

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Cited by 4 publications

References 63 publications

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Selective vitamin D receptor activator Paricalcitol and its potential benefits in hemodialysis patients with secondary hyperparathyroidism

Egshatyan

2022

Medicinskij sovet

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Currently, the incidence and prevalence of chronic kidney disease (CKD) are increasing annually worldwide, and clinical data show that CKD patients commonly experience relative vitamin D insufficiency or deficiency. Secondary hyperparathyroidism (SHPT) is a common complication in patients with end-stage renal disease and it is also common in hemodialysis patients. SHPT is an adaptive and in many cases ultimately maladaptive process that develops in response to declining kidney function, impaired phosphate excretion, failure to bioactivate vitamin D and hypocalcemia. SHPT is characterized by persistently elevated levels of parathyroid hormone (PTH) and complicated by important disturbances in mineral metabolism. Maintaining the level of vitamin D and parathyroid hormone concentrations in the target range reduce its associated complications (e.g., fractures, chronic kidney disease and cardiovascular calcification). Effective therapeutic interventions are highly desirable if the morbidity and mortality associated with uncontrolled SHPT are to be reduced. Major renal guidelines recommend use of vitamin D for secondary hyperparathyroidism in chronic kidney disease. However, because of the difficulties associated with lowering PTH while simultaneously controlling serum levels of calcium and phosphorous, traditional therapies for managing SHPT have several limitations. Selective vitamin D receptor activator paricalcitol mainly targets vitamin D receptors (VDR) in the parathyroid glands, has less effect on VDR in the intestine and other tissues, inhibits PTH strongly, triggers less hypercalcemia, and has less effect on intestinal absorption of calcium, phosphorus and bone metabolism and significantly lowers renin levels, albuminuria and blood pressure, which is supported by the results of most studies conducted over these decades. The article is devoted to the problem of treatment of patients with SHPT inpatient with renal replacement therapy with program hemodialysis.

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Selective vitamin D receptor activator Paricalcitol and its potential benefits in hemodialysis patients with secondary hyperparathyroidism

Egshatyan

2022

Medicinskij sovet

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Screening Investigations of Vitamin D Content Different Population Groups of Big Sochi

Chzhu

Araviashvili

2021

Mediko-farmacevtičeskij žurnal "Pulʹs"

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Data on vitamin D metabolism suggest that it is a secosteroid prohormone. Current studies have shown that the mechanism of functioning of vitamin D is associated with a specific receptor of the hormonally active form of this vitamin (VDR). Receptors for vitamin D are identified in more than 40 target tissues of the body (bones, muscles, intestine, kidneys, heart, prostate gland, mammary glands, pancreas), in particular in most cells of the immune system and epithelial cells lining the mucous membranes which determines many of its biological effects. Vitamin D levels affect 172 major physiological indicators of human health [1,2]. Determining the optimal values for vitamin D connect in body plays a key role in establishment of recommendations for maintaining the normal status of this vitamin throughout the year, including winter months. In connection with the discovery of new extraskeletal (non-calcemic) functions of vitamin, as well as the influence on its content of geographical, ethnic and age factors, it became necessary to clarify the norms of physiological need for this vitamin based on regional conditions [2]. The work presented is a part of comprehensive research on optimizing the reference values of diagnostic systems and enzyme immunoassay systems, in particular, to definite human populations. The investigations presented out in this work revealed the most vulnerable groups in relation to D deficiency and revealed significant seasonal degradation of vitamin content, despite the fairly comfortable climate conditions of the coast of Greater Sochi.

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The influence of uv radiation on health and professional activities of athletes

Архангельская

Ivkina²,

Гуревич

et al. 2021

Fizioterapevt (Physiotherapist)

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Currently, the problem of improving sports performance and increasing professional longevity is relevant, which is directly related to the indicators of physical performance and the prevention of diseases, including those of the musculoskeletal system that are common in athletes. Intense loads and muscle fatigue lead to a constant overstrain and increase the risk of injury and the development of diseases of the musculoskeletal system in this professional group. The balance of calcium and phosphorus in the body is essential for ensuring the normal structure and function of the musculoskeletal system, and vitamin D plays a primary role in maintaining this balance. Recent studies aimed at researching the availability of vitamin D for athletes often reveal insufficiency and defi ciency of this vitamin. It is known that the main source of vitamin D is its formation in the skin by ultraviolet radiation; it is proved that even with prolonged and intense sunlight there is no overproduction, and therefore, no toxic eff ects associated with hypervitaminosis D. However, the effect of UV rays on the human body can lead to the development of skin malignancies, therefore, the use of sunscreens is necessary during insolation.

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Non-classical effects of vitamin D

Cited by 4 publications

References 63 publications

Selective vitamin D receptor activator Paricalcitol and its potential benefits in hemodialysis patients with secondary hyperparathyroidism

Selective vitamin D receptor activator Paricalcitol and its potential benefits in hemodialysis patients with secondary hyperparathyroidism

Screening Investigations of Vitamin D Content Different Population Groups of Big Sochi

The influence of uv radiation on health and professional activities of athletes

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