2023
DOI: 10.1111/jdi.14048
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Non‐classical monocytes frequency and serum vitamin D3 levels are linked to diabetic foot ulcer associated with peripheral artery disease

Abstract: Aims/IntroductionPeripheral artery disease (PAD) serves as a risk factor for diabetic foot ulcers (DFUs). PAD pathology involves atherosclerosis and impaired immunity. Non‐classical monocytes are believed to have an anti‐inflammatory role. 1,25‐Dihydroxy vitamin D (vitamin D3) is claimed to have immune‐modulating and lipid‐regulating roles. Vitamin D receptor is expressed on monocytes. We aimed to investigate if circulating non‐classical monocytes and vitamin D3 were implicated in DFUs associated with PAD.Mate… Show more

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Cited by 4 publications
(1 citation statement)
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“…Amygdalin, also known as vitamin B17, induces Tregs expansion and upregulates the expression of IL‐10 and TGF‐β in ApoE −/− mice 216 . Orally administered vitamin D3 protects against atherosclerosis by increasing Tregs numbers, promoting tolerogenic DCs, increasing IL‐10 expression, and decreasing IL‐12 expression 217,218 . Therefore, the manipulation of Tregs numbers and immunosuppressive functions through pharmacological approaches (Table 3) may be a promising therapeutic tool for treating atherosclerotic diseases.…”
Section: Targeting Tregs For the Prevention And Treatment Of Cvdsmentioning
confidence: 99%
“…Amygdalin, also known as vitamin B17, induces Tregs expansion and upregulates the expression of IL‐10 and TGF‐β in ApoE −/− mice 216 . Orally administered vitamin D3 protects against atherosclerosis by increasing Tregs numbers, promoting tolerogenic DCs, increasing IL‐10 expression, and decreasing IL‐12 expression 217,218 . Therefore, the manipulation of Tregs numbers and immunosuppressive functions through pharmacological approaches (Table 3) may be a promising therapeutic tool for treating atherosclerotic diseases.…”
Section: Targeting Tregs For the Prevention And Treatment Of Cvdsmentioning
confidence: 99%