Non-clinical studies of the effectiveness of specialized sports nutrition product for correction of physical efficiency and psycho-physiological condition during intensive loads

The observation program was attended by 50 professional hockey players, divided into 2 groups, respectively, teams (25 people).The participants of the main group received step therapy with cytoflavin: first intravenously drip 10 ml of the drug diluted in 200 ml of 5% glucose solution, for 10 days, then 2 tablets 2 times a day for 25 days. Pharmacological support of participants in the comparison group were excluded the preparations of succinic acid or other metabolic means. Laboratory parameters were evaluated in dynamics: before the training (point 1), in the middle of the preparatory stage (point 2) and 35 days after the start of training (after the entire course of step therapy) (point 3). According to the results of the study revealed that the parameters of red blood (number of red blood cells, hemoglobin level, average red blood cell volume, average hemoglobin content in the red blood cell (MCH), the average concentration of hemoglobin in the red blood cell (MCHC) were more stable against the background of the use of cytoflavin, and the values of aspartataminotransferase and creatinine decreased during the observation in the main group and increased in the comparison group so that at the point 3 level aspartataminotransferase (AST) in the main group became significantly lower than in the comparison group (p=0.039*), and the level of creatinine was equal at initially higher rate in the main group (p= 0.012*). MB - fraction of creatine phosphokinase (MB-CPK) in the blood decreased in the main group of athletes (in the evaluation test of Pillai p=0,004), did not significantly change in the comparison group. There were no significant differences in the indicators of cortisol and testosterone between the groups, although the level of cortisol decreased in the athletes of the main group, and testosterone - increased, while in the comparison group the situation was the opposite. By the end of the follow-up, a statistically significant decrease in lactate levels before and after training was revealed in the group of athletes taking cytoflavin.

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The influence of cytoflavin staged therapy on dynamics of laboratory values in professional athletes during first stage of preparation for the game season.

Ачкасов

Kurshev

Zaborova

et al. 2018

Klin. med.

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Comparative analysis of the integration of autologous and allogeneic cryopreserved tendons in the femoral canal on a model of laboratory animals

Budaev,

Tropskaya,

Borovkova

et al. 2024

vmirvz

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Allogeneic tendon grafts are seriously demand in knee joint plastic surgery. The novel method of tendon cryopreservation, including sterilization with supercritical carbon dioxide, was developed in N.V. Sklifosovsky Research Institute for Emergency Cryopreserved tendons retain their normal fiber structure without significant loss of mechanical properties. At the next stage it was necessary to evaluate cryopreserved tendons′ integration inside bone canal in experimental animals.The aim of study. To evaluate morphologic changes of autologous and allogeneic tendons inside the femur in rats and to determine the effect of tendon transplantation on the physical activity.Material and methods. The study was conducted on white inbreed male rats. Three groups of animals were formed: the control group (animals without tendon transplantation), the 1st experimental group – animals with autologous tendon transplantation, the 2nd experimental group – animals with allogeneic tendon transplantation. In animals of the experimental groups the through channel was formed in the distal metaepiphysis of the femur and a tail tendon graft 0.5 x 0.1 cm was placed there. To assess the physical activity of the animals, we studied maximum distance that the animals could run 3 and 6 weeks after transplantation was determined, using treadmill test. The graft structure was evaluated on histological preparations in transmitted light, stained with hematoxylin-eosin and Van Gieson′s stain. To assess the preservation of collagen fibers we checked the autofluorescence intensity of collagen.Results. According to the treadmill test, the distance run by the animals of both experimental groups did not significantly differ from the values in the control group. Histological analysis after 3 weeks in both experimental groups revealed signs of fibers′ decomposition in the absence of inflammatory infiltration and maintaining close contact with bone trabeculae. The autofluorescence intensity of the collagen fibers in grafts corresponded to normal or was close to normal. After 6 weeks, the animals of both experimental groups revealed areas of graft fusion with their own bone, Sharpe fibers were actively formed. In both groups, numerous small vessels with diameters up to 10 microns were detected in the area of tendon-bone contact. Infiltration of grafts by inflammatory cells was absent or very insignificant, active migration of fibroblasts to the tendon area was also not observed. In both groups, tendon grafts had areas where fiber decompactization was observed. In the area of contact with the bone, the autofluorescence of tendon fibers was sharply increased, which indicates the chemical cleavage of collagen. At 3 and 6 weeks after transplantation the effect of fixation (integration) of the tendon with bone tissue was observed in both experimental groups.Conclusions. Allogeneic tendon grafts did not cause a pronounced inflammatory or immune reaction in experimental animals. 6 weeks after transplantation of autologous and allogeneic tendons, the integration of grafts inside the femoral canal was observed. Cryopreserved allogeneic tendons were able to integrate into the body's own tissues without pronounced structural and functional disorders. According to the treadmill test, the distance covered by the animals of both experimental groups did not differ statistically significantly from the values in the control group (without tendon transplantation) after 3 and 6 weeks

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Non-clinical studies of the effectiveness of specialized sports nutrition product for correction of physical efficiency and psycho-physiological condition during intensive loads

Cited by 2 publications

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The influence of cytoflavin staged therapy on dynamics of laboratory values in professional athletes during first stage of preparation for the game season.

The influence of cytoflavin staged therapy on dynamics of laboratory values in professional athletes during first stage of preparation for the game season.

Comparative analysis of the integration of autologous and allogeneic cryopreserved tendons in the femoral canal on a model of laboratory animals

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