Non-coding RNA regulation of macrophage function in asthma

Tian, Chunyan; Gao, Jiawei; Yang, Liuxin; Yuan, Xingxing

doi:10.1016/j.cellsig.2023.110926

Cited by 4 publications

(2 citation statements)

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“…These distinct macrophage populations within the placenta have the potential to exert a lasting impact on the polarization of macrophages in other organs, particularly the lungs. [32][33][34] The process of labor and birth introduces a significant shift in the immune milieu, reprogramming macrophages to accommodate the dynamic changes associated with parturition. This reprogramming, however, tends to blur the differences between macrophage states associated with various disease conditions.…”

Section: Discussionmentioning

confidence: 99%

Macrophage Polarizations in the Placenta and Lung are Associated with Bronchopulmonary Dysplasia

Mestan,

Sharma,

Lazar

et al. 2024

Preprint

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The intricate interplay between macrophage polarization and placenta vascular dysfunction has garnered increasing attention in the context of placental inflammatory diseases. This study delves into the complex relationship between macrophage polarization within the placenta and its potential impact on the development of vascular dysfunction and inflammatory conditions. The placenta, a crucial organ in fetal development, relies on a finely tuned balance of immune responses for proper functioning. Disruptions in this delicate equilibrium can lead to pathological conditions, including inflammatory diseases affecting the fetus and newborn infant. We explored the interconnectedness between placental macrophage polarization and its relevance to lung macrophages, particularly in the context of early life lung development. Bronchopulmonary dysplasia (BPD), the most common chronic lung disease of prematurity, has been associated with abnormal immune responses, and understanding the role of macrophages in this context is pivotal. The investigation aims to shed light on how alterations in placental macrophage polarization may contribute to lung macrophage behavior and, consequently, influence the development of BPD. By unraveling the intricate mechanisms linking macrophage polarization, placental dysfunction and BPD, this research seeks to provide insights that could pave the way for targeted therapeutic interventions. The findings may offer novel perspectives on preventing and managing placental and lung-related pathologies, ultimately contributing to improved maternal and neonatal health outcomes.

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Section: Discussionmentioning

confidence: 99%

Macrophage Polarizations in the Placenta and Lung are Associated with Bronchopulmonary Dysplasia

Mestan,

Sharma,

Lazar

et al. 2024

Preprint

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“…Non-Coding RNA 2023, 9, x FOR PEER REVIEW 3 of 14 classification of ncRNAs is discussed elsewhere [36,37]. Emerging evidence shows that these ncRNAs play roles in macrophage polarization related to allergies [38,39]. Herein, we summarize the current knowledge on ncRNA-regulated macrophage functions related to allergies, focusing on microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), and discuss the possibility of identifying novel potential targets for allergy treatment.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Macrophage Polarization in Allergy by Noncoding RNAs

Ishibashi,

Muljo,

Islam

2023

ncRNA

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Allergy is a type 2 immune reaction triggered by antigens known as allergens, including food and environmental substances such as peanuts, plant pollen, fungal spores, and the feces and debris of mites and insects. Macrophages are myeloid immune cells with phagocytic abilities that process exogenous and endogenous antigens. Upon activation, they can produce effector molecules such as cytokines as well as anti-inflammatory molecules. The dysregulation of macrophage function can lead to excessive type 1 inflammation as well as type 2 inflammation, which includes allergic reactions. Thus, it is important to better understand how macrophages are regulated in the pathogenesis of allergies. Emerging evidence highlights the role of noncoding RNAs (ncRNAs) in macrophage polarization, which in turn can modify the pathogenesis of various immune-mediated diseases, including allergies. This review summarizes the current knowledge regarding this topic and considers three classes of ncRNAs: microRNAs, long ncRNAs, and circular ncRNAs. Understanding the roles of these ncRNAs in macrophage polarization will provide new insights into the pathogenesis of allergies and identify potential novel therapeutic targets.

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