Non-coding RNAs and Hypertension–Unveiling Unexpected Mechanisms of Hypertension by the Dark Matter of the Genome

Murakami, Kazuo

doi:10.2174/1573402111666150401105317

Cited by 17 publications

(15 citation statements)

References 134 publications

(109 reference statements)

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“…In recent years, with the development of sequencing technology, numerous genes and gene families have been identified. In addition, some transcriptomes, which were previously regarded as being "dark" or "junk" having either no or only a weak protein-coding ability, also have been identified [1][2][3]. However, multiple functions have recently been discovered for noncoding regions.…”

Section: Introductionmentioning

confidence: 99%

Integrative Analysis of the lncRNA and mRNA Transcriptome Revealed Genes and Pathways Potentially Involved in the Anther Abortion of Cotton (Gossypium hirsutum L.)

Qin

Dong

et al. 2019

Genes

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Cotton plays an important role in the economy of many countries. Many studies have revealed that numerous genes and various metabolic pathways are involved in anther development. In this research, we studied the differently expressed mRNA and lncRNA during the anther development of cotton between the cytoplasmic male sterility (CMS) line, C2P5A, and the maintainer line, C2P5B, using RNA-seq analysis. We identified 17,897 known differentially expressed (DE) mRNAs, and 865 DE long noncoding RNAs (lncRNAs) that corresponded to 1172 cis-target genes at three stages of anther development using gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment of DE mRNAs; and cis-target genes of DE lncRNAs probably involved in the degradation of tapetum cells, microspore development, pollen development, and in the differentiation, proliferation, and apoptosis of the anther cell wall in cotton. Of these DE genes, LTCONS_00105434, LTCONS_00004262, LTCONS_00126105, LTCONS_00085561, and LTCONS_00085561, correspond to cis-target genes Ghir_A09G011050.1, Ghir_A01G005150.1, Ghir_D05G003710.2, Ghir_A03G016640.1, and Ghir_A12G005100.1, respectively. They participate in oxidative phosphorylation, flavonoid biosynthesis, pentose and glucuronate interconversions, fatty acid biosynthesis, and MAPK signaling pathway in plants, respectively. In summary, the transcriptomic data indicated that DE lncRNAs and DE mRNAs were related to the anther development of cotton at the pollen mother cell stage, tetrad stage, and microspore stage, and abnormal expression could lead to anther abortion, resulting in male sterility of cotton.

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Section: Introductionmentioning

confidence: 99%

Integrative Analysis of the lncRNA and mRNA Transcriptome Revealed Genes and Pathways Potentially Involved in the Anther Abortion of Cotton (Gossypium hirsutum L.)

Qin

Dong

et al. 2019

Genes

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“…Rather than just being affected by variations in the coding genome, epigenetic mechanisms, including microRNAs, histone modification, and methylation, are increasingly seen to play a role in the development of hypertension [101]. Non-coding areas of the human genome, which make up almost 99% of it, were long regarded as "junk DNA" [102]. In contrast, the Encyclopedia of DNA Elements (ENCODE) project has shown that non-coding DNA is a critical element of gene function regulation across cell, tissue, and organ types [103,104].…”

Section: Epigenomicsmentioning

confidence: 99%

“…Regulatory elements, such as transcription-factorbinding sites, histone modification, chromatin structure, and DNA methylation, are highly cell-type specific. Those non-coding regions are extensively transcribed into non-coding RNAs, such as microRNAs and long-non-coding RNAs (lncRNA), with various functions including the influence of the pathophysiology of hypertension [102]. For example, micro-RNAs seem to be associated with hypertension via sympathetic nerve activity, ion transporters in the kidney, endothelial function, vascular smooth muscle phenotype transformation, and communication between cells [102].…”

Section: Epigenomicsmentioning

confidence: 99%

“…Those non-coding regions are extensively transcribed into non-coding RNAs, such as microRNAs and long-non-coding RNAs (lncRNA), with various functions including the influence of the pathophysiology of hypertension [102]. For example, micro-RNAs seem to be associated with hypertension via sympathetic nerve activity, ion transporters in the kidney, endothelial function, vascular smooth muscle phenotype transformation, and communication between cells [102]. In another study, expression levels of microRNAs implicated in vascular smooth muscle cell phenotypic modulation were assessed in patients with hypertension and healthy controls.…”

Section: Epigenomicsmentioning

confidence: 99%

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Relevance of Personalized Health Care in Patients with Arterial Hypertension: Where are we now?

Binder¹,

Schäfer²,

Kaiser³

et al. 2016

Update on Essential Hypertension

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Personalized health care (PHC) or precision medicine is a new medical concept that aids in treatment decisions for patients by tailoring them to their individual needs. It often employs genetic testing to select appropriate and optimal therapies (pharmacogenomics). Although this concept is widely applied in oncology, the field of hypertension is still in the early stages and "personalization" is currently limited to tailoring antihypertensive treatment according to age, comorbidities, and ethnicity. Despite the fact that incomplete/lack of treatment response occurs in 10-30% of hypertensive patients for angiotensin-converting enzyme (ACE) inhibitors and in 15-25% for β-blockers, major continental guidelines still recommend the use of antihypertensive agents in a "onesize-fits-all" approach, neglecting the 1977 postulation of the Joint National Committee that "all patients must receive individualized therapy programs." The arrival of molecular testing offers new possibilities to differentiate monogenetic from polygenetic disorders and to identify associations between hypertension and drug response to corresponding genes. Up to 50% of the variation in blood pressure (BP) is attributable to genetic factors. Polymorphisms have been identified and studied in genes for BPmodifying receptors, such as ADBR (β-adrenergic receptors), and pharmacological pathways (GNB3, RAAS system). Approximately, one-quarter of the currently analyzed gene polymorphisms demonstrate significant pharmacogenetic effects (ADD1 Gly460Trp and the insertion/deletion [I/D] polymorphism in intron 16 of the ACE gene). Several large screening studies are currently ongoing to assess the impact on efficacy of antihypertensive medication of variants in hypertension-susceptibility genes. The GenHAT substudy of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) assessed the predictive validity of the ACE I/D genotype for coronary heart disease. The Family Blood Pressure Program included 11,079 participants to map genetic variants associated with hypertension. In this review chapter, we display the current body of knowledge regarding PHC in the treatment of hypertension. In particular, we highlight genetic variants associated with hyperten

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“…ncRNA is a functional RNA molecule that is transcribed from DNA, but not translated into proteins and has been shown to be involved in regulating gene expression and inhibiting the translation and degradation of messenger RNAs [ 13 ]. Two major types of ncRNA, namely microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been extensively studied in both hypertensive patients and animal models as outlined in a number of review papers [ 14 , 15 ]. This review will present an update of the most recent progress in both miRNAs and lncRNA focusing on their links to the physiological regulation and therapeutic potential in systemic hypertension.…”

Section: Introductionmentioning

confidence: 99%

Non-Coding RNA in the Pathogenesis, Progression and Treatment of Hypertension

Leimena

Qiu

2018

IJMS

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Hypertension is a complex, multifactorial disease that involves the coexistence of multiple risk factors, environmental factors and physiological systems. The complexities extend to the treatment and management of hypertension, which are still the pursuit of many researchers. In the last two decades, various genes have emerged as possible biomarkers and have become the target for investigations of specialized drug design based on its risk factors and the primary cause. Owing to the growing technology of microarrays and next-generation sequencing, the non-protein-coding RNAs (ncRNAs) have increasingly gained attention, and their status of redundancy has flipped to importance in normal cellular processes, as well as in disease progression. The ncRNA molecules make up a significant portion of the human genome, and their role in diseases continues to be uncovered. Specifically, the cellular role of these ncRNAs has played a part in the pathogenesis of hypertension and its progression to heart failure. This review explores the function of the ncRNAs, their types and biology, the current update of their association with hypertension pathology and the potential new therapeutic regime for hypertension.

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Non-coding RNAs and Hypertension–Unveiling Unexpected Mechanisms of Hypertension by the Dark Matter of the Genome

Cited by 17 publications

References 134 publications

Integrative Analysis of the lncRNA and mRNA Transcriptome Revealed Genes and Pathways Potentially Involved in the Anther Abortion of Cotton (Gossypium hirsutum L.)

Integrative Analysis of the lncRNA and mRNA Transcriptome Revealed Genes and Pathways Potentially Involved in the Anther Abortion of Cotton (Gossypium hirsutum L.)

Relevance of Personalized Health Care in Patients with Arterial Hypertension: Where are we now?

Non-Coding RNA in the Pathogenesis, Progression and Treatment of Hypertension

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