Non-Coding RNAs as Potential Targets for Diagnosis and Treatment of Oral Lichen Planus: A Narrative Review

Kim, Tae-Jun; Kim, Yu Gyung; Jung, Won; Jang, Sungil; Ko, Hyoung-Gon; Park, Chan Ho; Byun, Jin-Seok; Kim, Do-Yeon

doi:10.3390/biom13111646

Cited by 3 publications

(1 citation statement)

References 176 publications

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“…In addition, direct immunofluorescence has been described as an auxiliary diagnostic tool useful for cases with similar characteristics to other diseases [59]. Among the proposed biomarkers for the diagnosis of OLP and other oral lesions, including cancer, there are also microRNAs and other non-coding RNAs; however, further validation experiments are needed to clearly elucidate their diagnostic role [60,61] Recently, liquid biopsy has attracted great interest in the early diagnosis of OLP and other oral lesions [62]. Specifically, liquid biopsy offers several advantages compared to conventional tissue biopsies, including minimal invasiveness, the repeatability of the sampling, and the ability to evaluate dynamic changes in disease progression and biomarker alterations, including microbial changes [59].…”

Section: Olp Diagnosis Treatment and Malignant Potentialmentioning

confidence: 99%

Role of Oral Microbiota Dysbiosis in the Development and Progression of Oral Lichen Planus

Lavoro,

Cultrera,

Gattuso

et al. 2024

JPM

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Oral lichen planus (OLP) is a chronic inflammatory autoimmune disease of the oral cavity with malignant potential affecting 1.01% of the worldwide population. The clinical patterns of this oral disorder, characterized by relapses and remissions of the lesions, appear on buccal, lingual, gingival, and labial mucosa causing a significant reduction in the quality of life. Currently, there are no specific treatments for this disease, and the available therapies with topical and systemic corticosteroids only reduce symptoms. Although the etiopathogenesis of this pathological condition has not been completely understood yet, several exogenous and endogenous risk factors have been proposed over the years. The present review article summarized the underlying mechanisms of action involved in the onset of OLP and the most well-known triggering factors. According to the current data, oral microbiota dysbiosis could represent a potential diagnostic biomarker for OLP. However, further studies should be undertaken to validate their use in clinical practice, as well as to provide a better understanding of mechanisms of action and develop novel effective intervention strategies against OLP.

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Section: Olp Diagnosis Treatment and Malignant Potentialmentioning

confidence: 99%

Role of Oral Microbiota Dysbiosis in the Development and Progression of Oral Lichen Planus

Lavoro,

Cultrera,

Gattuso

et al. 2024

JPM

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Immunophenotypic and Gene Expression Analyses of the Inflammatory Microenvironment in High-Grade Oral Epithelial Dysplasia and Oral Lichen Planus

Flores-Hidalgo,

Phero,

Steward-Tharp

et al. 2024

Head and Neck Pathol

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Background Oral lichen planus (OLP) and oral epithelial dysplasia (OED) present diagnostic challenges due to clinical and histologic overlap. This study explores the immune microenvironment in OED, hypothesizing that immune signatures could aid in diagnostic differentiation and predict malignant transformation. Methods Tissue samples from OED and OLP cases were analyzed using immunofluorescence/immunohistochemistry (IF/IHC) for CD4, CD8, CD163/STAT1, and PD-1/PDL-1 expression. RNA-sequencing was performed on the samples, and data was subjected to CIBERSORTx analysis for immune cell composition. Gene Ontology analysis on the immune differentially expressed genes was also conducted. Results In OED, CD8 + T-cells infiltrated dysplastic epithelium, correlating with dysplasia severity. CD4 + lymphocytes increased in the basal layer. STAT1/CD163 + macrophages correlated with CD4 + intraepithelial distribution. PD-1/PDL-1 expression varied. IF/IHC analysis revealed differential immune cell composition between OED and OLP. RNA-sequencing identified upregulated genes associated with cytotoxic response and immunosurveillance in OED. Downregulated genes were linked to signaling, immune cell recruitment, and tumor suppression. Conclusions The immune microenvironment distinguishes OED and OLP, suggesting diagnostic potential. Upregulated genes indicate cytotoxic immune response in OED. Downregulation of TRADD, CX3CL1, and ILI24 implies dysregulation in TNFR1 signaling, immune recruitment, and tumor suppression. This study contributes to the foundation for understanding immune interactions in OED and OLP, offering insights into future objective diagnostic avenues.

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Peculiarities of the format of genetic blood systems in patients with oral lichen planus

Proschenko,

Zelinskaya,

Proschenko

et al. 2024

Medicni Perspektivi

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The number of patients with oral lichen planus (OLP) has increased due to the raise of aggressive forms of the disease (erosive, ulcerative and hyperkeratotic forms) with a possible risk of malignancy. There are isolated researches which indicate a genetic determinism to OLP, but more often these conclusions are based on insufficiently adequate and out of date methods, which make it impossible to correctly interpret the obtained data. The aim was to identify a genetical predisposition with a programmed risk to the oral lichen planus. The main group – 278 patients with the OLP (aged 26-65 years). The control group – 298 people (blood donors) who didn’t have dental diseases, as well as diseases of internal organs and systems. The groups were homogeneous by gender and age. In our research we used such methods: clinical, radiological, immunogenetic, statistical methods were used. The erosive form of OLP was associated with 0(I) group in 54.2±0.4% of cases, while the hyperkeratotic form was associated with group 0(I) only in 28.7±1.8% of cases. B(ІІІ) and AB(ІB) groups were less often associated with the erosive form of OLP and were observed in 17.3±0.1% and 2.0±0.1% of cases, respectively. The integration of A(ІІ) group in the erosive form of OLP was 30.5±0.1%, but the indicator was higher than in individuals with B(III) and AB(IV) groups. Hyperkeratotic form of OLP was more often observed in A(II) carriers than in 0(I) and was 44.1±0.1% versus 28.7±1.8%, respectively. With blood group B (ІІІ), the relationship with OLP is not traced. Correlative relationship with erythrocyte blood antigens of the ABO system in patients with oral lichen planus was established. Risk groups for the development of erosive and hyperkeratotic forms of lichen planus in patients with gastrointestinal tract pathology O(I)>A(II)>B(III) – with erosive form and A(II)>O(I)>B(III)) – with hyperkeratosis.

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Non-Coding RNAs as Potential Targets for Diagnosis and Treatment of Oral Lichen Planus: A Narrative Review

Cited by 3 publications

References 176 publications

Role of Oral Microbiota Dysbiosis in the Development and Progression of Oral Lichen Planus

Role of Oral Microbiota Dysbiosis in the Development and Progression of Oral Lichen Planus

Immunophenotypic and Gene Expression Analyses of the Inflammatory Microenvironment in High-Grade Oral Epithelial Dysplasia and Oral Lichen Planus

Peculiarities of the format of genetic blood systems in patients with oral lichen planus

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