Non-Coding RNAs: Foes or Friends for Targeting Tumor Microenvironment

Szymanowska, Anna; Rodriguez-Aguayo, Cristian; Lopez-Berestein, Gabriel; Amero, Paola

doi:10.3390/ncrna9050052

Cited by 5 publications

(2 citation statements)

References 229 publications

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“…Changes at the cellular, genetic, and epigenetic levels contribute to cancer development and progression [34]. Epigenetic regulations by sncRNAs, such as miRNAs, are crucial for controlling cancer pathogenesis by regulating gene transcription, translation, and activity [34]. Indeed, miRNAs can act as tumor suppressors or as oncogenes in the function of how they modulate their target genes.…”

Section: Discussionmentioning

confidence: 99%

Transgenerational Transmission of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Effects in Human Granulosa Cells: The Role of MicroRNAs

Gaspari,

Haouzi,

Gennetier

et al. 2024

IJMS

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Endocrine-disrupting chemicals (EDCs) might contribute to the increase in female-specific cancers in Western countries. 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) is considered the “prototypical toxicant” to study EDCs’ effects on reproductive health. Epigenetic regulation by small noncoding RNAs (sncRNAs), such as microRNAs (miRNA), is crucial for controlling cancer development. The aim of this study was to analyze transcriptional activity and sncRNA expression changes in the KGN cell line after acute (3 h) and chronic (72 h) exposure to 10 nM TCDD in order to determine whether sncRNAs’ deregulation may contribute to transmitting TCDD effects to the subsequent cell generations (day 9 and day 14 after chronic exposure). Using Affymetrix GeneChip miRNA 4.0 arrays, 109 sncRNAs were found to be differentially expressed (fold change < −2 or >2; p-value < 0.05) between cells exposed or not (control) to TCDD for 3 h and 72 h and on day 9 and day 14 after chronic exposure. Ingenuity Pathway Analysis predicted that following the acute and chronic exposure of KGN cells, sncRNAs linked to cellular development, growth and proliferation were downregulated, and those linked to cancer promotion were upregulated on day 9 and day 14. These results indicated that TCDD-induced sncRNA dysregulation may have transgenerational cancer-promoting effects.

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Section: Discussionmentioning

confidence: 99%

Transgenerational Transmission of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Effects in Human Granulosa Cells: The Role of MicroRNAs

Gaspari,

Haouzi,

Gennetier

et al. 2024

IJMS

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show abstract

“…The communication between TME cells relies partially on cytokines, proteins, and non-coding RNAs (nc-RNAs) transported by exosomes. Therefore, understanding the interaction between these cells and the TME's composition may help in designing novel targeted therapies using dCas9 systems and aptamers [9,10].…”

Section: Introductionmentioning

confidence: 99%

Aptamers as Potential Therapeutic Tools for Ovarian Cancer: Advancements and Challenges

Szymanowski,

Szymanowska,

Bielawska

et al. 2023

Cancers

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Ovarian cancer (OC) is the most common lethal gynecologic cause of death in women worldwide, with a high mortality rate and increasing incidence. Despite advancements in the treatment, most OC patients still die from their disease due to late-stage diagnosis, the lack of effective diagnostic methods, and relapses. Aptamers, synthetic, short single-stranded oligonucleotides, have emerged as promising anticancer therapeutics. Their ability to selectively bind to target molecules, including cancer-related proteins and receptors, has revolutionized drug discovery and biomarker identification. Aptamers offer unique insights into the molecular pathways involved in cancer development and progression. Moreover, they show immense potential as drug delivery systems, enabling targeted delivery of therapeutic agents to cancer cells while minimizing off-target effects and reducing systemic toxicity. In the context of OC, the integration of aptamers with non-coding RNAs (ncRNAs) presents an opportunity for precise and efficient gene targeting. Additionally, the conjugation of aptamers with nanoparticles allows for accurate and targeted delivery of ncRNAs to specific cells, tissues, or organs. In this review, we will summarize the potential use and challenges associated with the use of aptamers alone or aptamer–ncRNA conjugates, nanoparticles, and multivalent aptamer-based therapeutics for the treatment of OC.

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Exploring the role of noncoding RNAs in cancer diagnosis, prognosis, and precision medicine

Eldakhakhny,

Sutaih,

Siddiqui

et al. 2024

Non-coding RNA Research

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Non-Coding RNAs: Foes or Friends for Targeting Tumor Microenvironment

Cited by 5 publications

References 229 publications

Transgenerational Transmission of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Effects in Human Granulosa Cells: The Role of MicroRNAs

Transgenerational Transmission of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Effects in Human Granulosa Cells: The Role of MicroRNAs

Aptamers as Potential Therapeutic Tools for Ovarian Cancer: Advancements and Challenges

Exploring the role of noncoding RNAs in cancer diagnosis, prognosis, and precision medicine

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