Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatments

Sun, Wanli; Xu, Juping; Wang, Li; Jiang, Yuchen; Cui, Jingrun; Su, Xin; Yang, Fan; Tian, Li; Si, Zeyu; Xing, Yanwei

doi:10.3389/fcvm.2022.946137

Cited by 5 publications

(2 citation statements)

References 188 publications

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“…All the above induce cardiomyocyte aging and disruption. Some miRNAs can be used as a biomarkers for the early detection of cardiac cell toxicity after radiation therapy and early detection of CVD but they also can be used as potential therapeutic targets to reverse these toxic effects [ 10 ].…”

Section: Resultsmentioning

confidence: 99%

Radiation Treatment Mechanisms of Cardiotoxicity: A Systematic Review

Siaravas

Katsouras

Sioka

2023

IJMS

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Radiotherapy may be used alone or in combination with chemotherapy for cancer treatment. There are many mechanisms of radiation treatment exposure to toxicities. Our aim was to summarize the literature about known mechanisms of radiation-induced cardiac toxicities. We performed a systematic review of the literature on the PubMed database until October 2022 about cardiovascular toxicities and radiation therapy exposure. Only systematic reviews, meta-analyses, and reviews were selected. Out of 1429 publications screened, 43 papers met inclusion criteria and were selected for the umbrella review process. Microvascular and macrovascular complications could lead to adverse cardiac effects. Many radiotherapy-associated risk factors were responsible, such as the site of radiation treatment, beam proximity to heart tissues, total dosage, the number of radiotherapy sessions, adjuvant chemotherapeutic agents used, and patient traditional cardiovascular risk factors, patient age, and gender. Moreover, important dosage cutoff values could increase the incidence of cardiac toxicities. Finally, the time from radiation exposure to cardiac side effects was assessed. Our report highlighted mechanisms, radiation dosage values, and the timeline of cardiovascular toxicities after radiation therapy. All of the above may be used for the assessment of cardiovascular risk factors and the development of screening programs for cancer patients.

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Section: Resultsmentioning

confidence: 99%

Radiation Treatment Mechanisms of Cardiotoxicity: A Systematic Review

Siaravas

Katsouras

Sioka

2023

IJMS

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“…One such studies indicated that crocin ameliorates arsenic trioxide-induced cardiotoxicity by reducing OS, inflammation, and apoptosis ( 170 , 171 ), magnesium isoglycyrrhizinate attenuates via Nrf2 and TLR4/NF-κB signaling pathways arsenic trioxide-induced cardiotoxicity ( 172 ). In addition, microRNAs and non-coding RNAs are also involved in the pathogenesis of radiotherapy-associated cardiotoxicity ( 173 – 175 ), mitochondrial fusion ( 176 ), and cellular scorching ( 177 ). It is also a hot topic of current research that TCM can exert anti-cardiotoxic effects through these pathways, and we look forward to seeing more of these findings.…”

Section: Discussionmentioning

confidence: 99%

Role and molecular mechanism of traditional Chinese medicine in preventing cardiotoxicity associated with chemoradiotherapy

Wen

et al. 2022

Front. Cardiovasc. Med.

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Cardiotoxicity is a serious complication of cancer therapy. It is the second leading cause of morbidity and mortality in cancer survivors and is associated with a variety of factors, including oxidative stress, inflammation, apoptosis, autophagy, endoplasmic reticulum stress, and abnormal myocardial energy metabolism. A number of studies have shown that traditional Chinese medicine (TCM) can mitigate chemoradiotherapy-associated cardiotoxicity via these pathways. Therefore, this study reviews the effects and molecular mechanisms of TCM on chemoradiotherapy-related cardiotoxicity. In this study, we searched PubMed for basic studies on the anti-cardiotoxicity of TCM in the past 5 years and summarized their results. Angelica Sinensis, Astragalus membranaceus Bunge, Danshinone IIA sulfonate sodium (STS), Astragaloside (AS), Resveratrol, Ginsenoside, Quercetin, Danggui Buxue Decoction (DBD), Shengxian decoction (SXT), Compound Danshen Dripping Pill (CDDP), Qishen Huanwu Capsule (QSHWC), Angelica Sinensis and Astragalus membranaceus Bunge Ultrafiltration Extract (AS-AM),Shenmai injection (SMI), Xinmailong (XML), and nearly 60 other herbs, herbal monomers, herbal soups and herbal compound preparations were found to be effective as complementary or alternative treatments. These preparations reduced chemoradiotherapy-induced cardiotoxicity through various pathways such as anti-oxidative stress, anti-inflammation, alleviating endoplasmic reticulum stress, regulation of apoptosis and autophagy, and improvement of myocardial energy metabolism. However, few clinical trials have been conducted on these therapies, and these trials can provide stronger evidence-based support for TCM.

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Non-coding RNAs regulating mitochondrial function in cardiovascular diseases

Ding

et al. 2023

J Mol Med

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Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatments

Cited by 5 publications

References 188 publications

Radiation Treatment Mechanisms of Cardiotoxicity: A Systematic Review

Radiation Treatment Mechanisms of Cardiotoxicity: A Systematic Review

Role and molecular mechanism of traditional Chinese medicine in preventing cardiotoxicity associated with chemoradiotherapy

Non-coding RNAs regulating mitochondrial function in cardiovascular diseases

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