Non-Coding RNAs in Kidney Diseases: The Long and Short of Them

Moreno, Juan Antonio; Hamza, Eya; Guerrero‐Hue, Melania; Rayego‐Mateos, Sandra; García‐Caballero, Cristina; Vallejo‐Mudarra, Mercedes; Metzinger, Laurent; Meuth, Valérie Metzinger-Le

doi:10.3390/ijms22116077

Cited by 26 publications

(17 citation statements)

References 117 publications

(138 reference statements)

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“…For example, our group revealed an exosomal miRNA signature associated with albuminuria in hypertension [ 29 ]. The lncRNA group has reached special relevance in the last years in health and diseases, but few studies have reported on the role of lncRNA in renal pathology [ 12 , 17 ]. In recent years, another ncRNA group, piRNAs, have gained prominence as modulators of disease pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…NcRNAs can be divided into three categories based on their length: ncRNAs longer than 200 nucleotides (nt), including ribosomal RNA (rRNA) and long non-coding RNA (lncRNA); ncRNAs between 40 nt and 200 nt, such as transfer RNA (tRNA), small nucleolar RNA (snoRNA) and small nuclear ribonucleic acid RNA (snRNA); and ncRNA shorter than 40 nt, such as microRNA (miRNA), piwi-interacting RNA (piRNA) and small interfering (siRNA) [ 8 , 9 ]. NcRNAs’ expression is tissue and cell-type specific under physiological conditions and plays an important role in many biological processes by regulating gene expression at epigenetic, transcriptional and post-transcriptional levels [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Exosomal and Plasma Non-Coding RNA Signature Associated with Urinary Albumin Excretion in Hypertension

Riffo‐Campos

Perez-Hernandez

Ortega

et al. 2022

IJMS

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Non-coding RNA (ncRNA), released into circulation or packaged into exosomes, plays important roles in many biological processes in the kidney. The purpose of the present study is to identify a common ncRNA signature associated with early renal damage and its related molecular pathways. Three individual libraries (plasma and urinary exosomes, and total plasma) were prepared from each hypertensive patient (with or without albuminuria) for ncRNA sequencing analysis. Next, an RNA-based transcriptional regulatory network was constructed. The three RNA biotypes with the greatest number of differentially expressed transcripts were long-ncRNA (lncRNA), microRNA (miRNA) and piwi-interacting RNA (piRNAs). We identified a common 24 ncRNA molecular signature related to hypertension-associated urinary albumin excretion, of which lncRNAs were the most representative. In addition, the transcriptional regulatory network showed five lncRNAs (LINC02614, BAALC-AS1, FAM230B, LOC100505824 and LINC01484) and the miR-301a-3p to play a significant role in network organization and targeting critical pathways regulating filtration barrier integrity and tubule reabsorption. Our study found an ncRNA profile associated with albuminuria, independent of biofluid origin (urine or plasma, circulating or in exosomes) that identifies a handful of potential targets, which may be utilized to study mechanisms of albuminuria and cardiovascular damage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exosomal and Plasma Non-Coding RNA Signature Associated with Urinary Albumin Excretion in Hypertension

Riffo‐Campos

Perez-Hernandez

Ortega

et al. 2022

IJMS

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“…Here, we show in a large cohort that the alterations in miR-126 levels are correlated with markers of endothelial dysfunction and cardiovascular disease, further expanding knowledge on the physiopathology of this non-coding RNA in CKD. In the future, long non-coding RNAs can also be developed as better biomarkers of CKD, as they are known to be more tissue-specific than miRNAs [39].…”

Section: Discussionmentioning

confidence: 99%

Syndecan-1 and Free Indoxyl Sulfate Levels Are Associated with miR-126 in Chronic Kidney Disease

Fourdinier

Glorieux

Brigant

et al. 2021

IJMS

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Chronic kidney disease (CKD) is a major cause of death worldwide and is associated with a high risk for cardiovascular and all-cause mortality. In CKD, endothelial dysfunction occurs and uremic toxins accumulate in the blood. miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients. In order to obtain a better understanding of the physiopathology of the disease, we correlated the levels of miR-126 with several markers of endothelial dysfunction, as well as the representative uremic toxins, in a large cohort of CKD patients at all stages of the disease. Using a univariate analysis, we found a correlation between eGFR and most markers of endothelial dysfunction markers evaluated in this study. An association of miR-126 with all the evaluated uremic toxins was also found, while uremic toxins were not associated with the internal control, specifically cel-miR-39. The correlation between the expression of endothelial dysfunction biomarker Syndecan-1, free indoxyl sulfate, and total p-cresyl glucuronide on one side, and miR-126 on the other side was confirmed using multivariate analysis. As CKD is associated with reduced endothelial glycocalyx (eGC), our results justify further evaluation of the role of correlated parameters in the pathophysiology of CKD.

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“…On the other hand, lncRNAs may be useful as potential biomarkers for the early diagnosis and prognosis of many diseases, including patients with CKD. The review summarizing the role of lncRNAs in kidney diseases, and their function as prognostic biomarkers has recently been published [ 40 ].…”

Section: Key Concepts Of Proteomics In Disease Analysismentioning

confidence: 99%

Applying Proteomics and Integrative “Omics” Strategies to Decipher the Chronic Kidney Disease-Related Atherosclerosis

Tracz

Łuczak

2021

IJMS

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Patients with chronic kidney disease (CKD) are at increased risk of atherosclerosis and premature mortality, mainly due to cardiovascular events. However, well-known risk factors, which promote “classical” atherosclerosis are alone insufficient to explain the high prevalence of atherosclerosis-related to CKD (CKD-A). The complexity of the molecular mechanisms underlying the acceleration of CKD-A is still to be defied. To obtain a holistic picture of these changes, comprehensive proteomic approaches have been developed including global protein profiling followed by functional bioinformatics analyses of dysregulated pathways. Furthermore, proteomics surveys in combination with other “omics” techniques, i.e., transcriptomics and metabolomics as well as physiological assays provide a solid ground for interpretation of observed phenomena in the context of disease pathology. This review discusses the comprehensive application of various “omics” approaches, with emphasis on proteomics, to tackle the molecular mechanisms underlying CKD-A progression. We summarize here the recent findings derived from global proteomic approaches and underline the potential of utilizing integrative systems biology, to gain a deeper insight into the pathogenesis of CKD-A and other disorders.

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Non-Coding RNAs in Kidney Diseases: The Long and Short of Them

Cited by 26 publications

References 117 publications

Exosomal and Plasma Non-Coding RNA Signature Associated with Urinary Albumin Excretion in Hypertension

Exosomal and Plasma Non-Coding RNA Signature Associated with Urinary Albumin Excretion in Hypertension

Syndecan-1 and Free Indoxyl Sulfate Levels Are Associated with miR-126 in Chronic Kidney Disease

Applying Proteomics and Integrative “Omics” Strategies to Decipher the Chronic Kidney Disease-Related Atherosclerosis

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