Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders

Sun, Ping; Hamblin, Milton; Yin, Ke‐Jie

doi:10.1186/s12987-022-00317-z

Cited by 38 publications

(23 citation statements)

References 223 publications

(328 reference statements)

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“…However, the animal models chosen for most of the current experiments demonstrating the recovery-promoting effects of miRNAs on SCI are nonprimate and future studies will likely also be conducted in non-human primates. (2) Most of the RNAs present in organisms are non-coding RNAs [99], such as miRNA, cir-cRNA, lncRNA, etc. As research progresses the interactions of these non-coding RNAs and the complex network of regulatory relationships are found to remain largely unknown.…”

Section: Discussionmentioning

confidence: 99%

Research Progress of MicroRNAs in Spinal Cord Injury

Deng¹,

Chen²

2023

J. Integr. Neurosci.

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Spinal cord injury is a serious and devastating condition. Recently, research into microRNAs (miRNAs) has become increasingly exhaustive and it has been determined that they are closely related to the pathophysiological processes of spinal cord injury. They participate in the regulation of the inflammatory response of spinal cord injury, the death of neuronal cells, and the repair of neural functions, which are related to the recovery of spinal cord injury. This review focuses on the relationship between miRNA and spinal cord injury, lists miRNA-324-5p, miRNA-221 and miRNA-124, which are helpful for the repair of spinal cord injury, and finally summarizes the current research progress of miRNA-based therapies, so as to provide a foundational reference for clinical and scientific researchers.

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Section: Discussionmentioning

confidence: 99%

Research Progress of MicroRNAs in Spinal Cord Injury

Deng¹,

Chen²

2023

J. Integr. Neurosci.

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“…Non-coding RNAs, including miRNAs and lncRNAs, play important roles in transcriptional and translational regulation in several cancers (43). lncRNAs act as miRNA sponges to reduce their regulatory abilities (44). Interactions between lncRNAs, miRNAs, and mRNAs form ceRNA networks (45).…”

Section: Discussionmentioning

confidence: 99%

Stemness-related gene signature for predicting therapeutic response in patients with esophageal cancer

Zhu¹,

Zhang²,

You³

et al. 2022

Transl Cancer Res TCR

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Background: Extensive research has indicated that tumor stemness promotes tumor progression. However, the underlying role of stemness-related genes (SRGs) in esophageal cancer (ESCA) remains unclear.Methods: This study identified differentially expressed stemness-related (DESR) messenger RNAs (mRNAs), microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) in ESCA, and correlated them with the clinical features of patients with ESCA to develop a prognostic risk assessment model. Functional analysis, protein-protein interaction (PPI) analysis, competing endogenous RNA (ceRNA) networks, and tumor-infiltrating immune cell analyses were performed to corroborate the results obtained from the model.Results: Correlation analysis of the stemness enrichment scores revealed 1,106 DESR genes (DESRGs), 84 DESRmiRNAs, and 320 DESRlncRNAs were identified from The Cancer Genome Atlas Esophageal Carcinoma (TCGA-ESCA) dataset. Network clustering was performed and the top 20 connection points were identified, including CDC20 that connects to 136 adjacent nodes. A ceRNA network was constructed, including 17 DESRmiRNAs, 44 DESRlncRNAs, and 55 DESRGs.Conclusions: NCAPG [log 2 fold change (FC) =1.81; q value =2.68×10 −11 ] was significantly upregulated in ESCA and positively correlated with resting natural killer (NK) cells, suggesting that human NK cells rest via the overexpression of NCAPG in ESCA. hsa-miR-1269a is significantly upregulated in ESCA patients with poor prognostic features. CD4 + resting memory T cells (P<0.01) were significantly negatively correlated with hsa-miR-1269a. The insights presented in this study will contribute to the development of innovative therapeutics for the treatment of patients with ESCA.

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“…Another level of regulation is by non-coding RNAs (including microRNAs, long non-coding RNAs and circular RNAs. Sun et al [ 112 ] have reviewed the roles of such RNAs at the BBB in different neurological disorders. One mechanism by which extracellular vesicles shed by one cell can affect other cells is by encapsulating micro RNAs.…”

Section: Genetics and The Blood-brain Barriersmentioning

confidence: 99%

A year in review: brain barriers and brain fluids research in 2022

Keep

Jones

Hamilton

et al. 2023

Fluids Barriers CNS

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This aim of this editorial is to highlight progress made in brain barrier and brain fluid research in 2022. It covers studies on the blood-brain, blood-retina and blood-CSF barriers (choroid plexus and meninges), signaling within the neurovascular unit and elements of the brain fluid systems. It further discusses how brain barriers and brain fluid systems are impacted in CNS diseases, their role in disease progression and progress being made in treating such diseases.

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Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders

Cited by 38 publications

References 223 publications

Research Progress of MicroRNAs in Spinal Cord Injury

Research Progress of MicroRNAs in Spinal Cord Injury

Stemness-related gene signature for predicting therapeutic response in patients with esophageal cancer

A year in review: brain barriers and brain fluids research in 2022

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