Non-coding RNAs: long non-coding RNAs and microRNAs in endocrine-related cancers

Klinge, Carolyn M.

doi:10.1530/erc-17-0548

Cited by 100 publications

(83 citation statements)

References 231 publications

(158 reference statements)

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“…LncRNAs have been suggested to play essential roles in progression of prostate cancer through interacting with miR-NAs and decoying proteins. 21 Recently, lncRNAs-mediated regulatory networks show great promise for better understanding the mechanism of prostate cancer progression. 22 In this study, we focused on the role and mechanism of PCA3 in prostate cancer progression and rst provided the view that PCA3/miR-1/CDK4 axis was involved in glycolysis, viability and apoptosis in prostate cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Retracted Article: Long noncoding RNA PCA3 regulates glycolysis, viability and apoptosis by mediating the miR-1/CDK4 axis in prostate cancer

Niu

Mao

et al. 2018

RSC Adv.

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Section: Discussionmentioning

confidence: 99%

Retracted Article: Long noncoding RNA PCA3 regulates glycolysis, viability and apoptosis by mediating the miR-1/CDK4 axis in prostate cancer

Niu

Mao

et al. 2018

RSC Adv.

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“…Non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been suggested to play essential roles in endocrine-related cancers, like breast, prostate, endometrial and thyroid cancers. 5 Thereinto, lncRNAs are a class of functional RNAs with more than 200 nucleotides in length, which have been indicated as promising biomarkers for development, diagnosis, prognosis as well as drug-resistance in PCa. 6,7 LncRNA colon cancer-associated transcript 1 (CCAT1) plays an important role in the prognosis and diagnosis of human cancers through regulating proliferation, migration, cell cycle progress, chemoresistance and other processes.…”

Section: Introductionmentioning

confidence: 99%

Knockdown of lncRNA CCAT1 enhances sensitivity of paclitaxel in prostate cancer via regulating miR-24-3p and FSCN1

Han

Wei

et al. 2020

Cancer Biology & Therapy

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Drug resistance limits the efficacy of chemotherapy in human cancers. Previous studies reported that long noncoding RNA colon cancer-associated transcript 1 (CCAT1) regulated progression of prostate cancer (PCa). However, the potential role of CCAT1 in the sensitivity of paclitaxel (PTX) in PCa and its mechanism remain largely unknown. The PTX-resistant PCa cells were established in PC3 and DU145 cells by increasing concentrations of PTX. The expressions of CCAT1, microRNA-24-3p (miR-24-3p) and fascin1 (FSCN1) were measured by quantitative real-time polymerase chain reaction. The viability and apoptosis were detected by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay, flow cytometry and western blot, respectively. The interaction among CCAT1, miR-24-3p and FSCN1 was explored by luciferase activity, RNA immunoprecipitation, RNA pull-down and western blot, respectively. Results showed that the expressions of CCAT1 were up-regulated and miR-24-3p was down-regulated in PCa and PTX-resistant PCa cells (PC3-TXR and DU145-TXR). Knockdown of CCAT1 or overexpression of miR-24-3p inhibited survival rate, half maximal inhibitory concentration (IC50) of PTX but increased apoptosis in PC3-TXR and DU145-TXR cells after treatment of PTX. miR-24-3p was bound to CCAT1 and its abrogation reversed knockdown of CCAT1-mediated increase of PTX sensitivity in PC3-TXR and DU145-TXR cells. Moreover, FSCN1 restoration attenuated miR-24-3p-mediated inhibition of PTX resistance. Besides, FSCN1 level was enhanced in PCa and PTX-resistant PCa cells and regulated by CCAT1 and miR-24-3p. Our data suggested interference of CCAT1 contributed to PTX sensitivity in PCa by regulating miR-24-3p and FSCN1, indicating a novel avenue for treatment of PCa through regulating chemoresistance.

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“…MicroRNAs (miRNAs) are a class of non-coding RNAs with ~22 nucleotides, which play essential roles in progression of endocrine-related cancers [4]. The available evidence indicates that miRNAs are associated with thyroid development, function and tumorigenesis [5].…”

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confidence: 99%

miR-17-5p knockdown inhibits proliferation, autophagy and promotes apoptosis in thyroid cancer via targeting PTEN

Shi¹,

Liu²,

Li³

et al. 2020

neo

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Thyroid cancer is one common endocrine malignancy with various pathological types. MicroRNAs (miRNAs) play essential roles in development, prognosis and treatment of thyroid cancer. However, the role of miR-17-5p in thyroid cancer progression and its mechanism remain poorly understood. The expressions of miR-17-5p and phosphatase and tensin homolog (PTEN) were measured in thyroid cancer tissues and cells by quantitative real-time polymerase chain reaction or western blot. Cell proliferation and apoptosis were detected by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay and flow cytometry, respectively. The protein levels of biomarkers in autophagy or protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) pathway were analyzed by western blot. The interaction between miR-17-5p and PTEN was probed by luciferase activity assay. We found that miR-17-5p expression was elevated and PTEN level was reduced in thyroid cancer tissues and cells compared with their corresponding controls. Knockdown of miR-17-5p or overexpression of PTEN suppressed cell proliferation and autophagy but promoted apoptosis in thyroid cancer cells. PTEN was indicated as a target of miR-17-5p and its interference reversed abrogation of miR-17-5p-mediated inhibition of proliferation and autophagy and increase of apoptosis. Moreover, downregulation of miR-17-5p impeded the activation of AKT/mTOR pathway in thyroid cancer cells, which was attenuated by silencing PTEN. Our data supported that knockdown of miR-17-5p upregulated PTEN expression, therefore leading to suppression of the malignancy of thyroid cancer and inactivation of AKT/mTOR pathway, providing a novel avenue for treatment of thyroid cancer.

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Non-coding RNAs: long non-coding RNAs and microRNAs in endocrine-related cancers

Cited by 100 publications

References 231 publications

Retracted Article: Long noncoding RNA PCA3 regulates glycolysis, viability and apoptosis by mediating the miR-1/CDK4 axis in prostate cancer

Retracted Article: Long noncoding RNA PCA3 regulates glycolysis, viability and apoptosis by mediating the miR-1/CDK4 axis in prostate cancer

Knockdown of lncRNA CCAT1 enhances sensitivity of paclitaxel in prostate cancer via regulating miR-24-3p and FSCN1

miR-17-5p knockdown inhibits proliferation, autophagy and promotes apoptosis in thyroid cancer via targeting PTEN

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