Non-coeliac gluten sensitivity: from Salerno to Rome

Shiha, Mohamed G; Raju, Suneil A; Penny, Hugo A; Sanders, David S

doi:10.1016/s2468-1253(23)00358-8

Cited by 1 publication

(2 citation statements)

References 8 publications

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“…There is only one previous study that shows that patients with NCGS, diagnosed by gluten-related symptoms and presence of IgG AGA, present with motility alterations that improve in most cases after a GFD [ 30 ]. Although an exact mechanism is yet to be elucidated, it is hypothesized that the innate but not adaptive immune response may play a part in NCGS [ 5 , 6 , 7 , 34 ]. Suggested factors encompass alterations in intestinal permeability, abnormal motility, and gut stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…Non-celiac gluten sensitivity (NCGS) is another important entity within the spectrum of gluten-related disorders [ 1 ]. Unlike CD, NCGS does not involve autoimmune mechanisms or intestinal damage [ 2 , 5 , 6 ]. While the precise mechanism remains unclear, it is suggested that the innate immune response, rather than the adaptive immune system, may be involved in NCGS [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Effect of a Gluten-Free Diet on Whole Gut Transit Time in Celiac Disease (CD) and Non-Celiac Gluten Sensitivity (NCGS) Patients: A Study Using the Wireless Motility Capsule (WMC)

Cobos-Quevedo,

Hernández,

Rivera-Gutiérrez

et al. 2024

JCM

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Background: This study explores the impact of a gluten-free diet (GFD) on regional gastrointestinal (GI) transit times in individuals with celiac disease (CD) and non-celiac gluten sensitivity (NCGS). While a GFD is established for managing CD and wheat allergy, its effects on NCGS remain controversial due to inconclusive evidence. Methods: Utilizing a wireless motility and pH capsule (WMC) to assess regional (measurements of gastric, small bowel, and colonic transit times) and whole gut transit, newly diagnosed CD (n = 12) and NCGS (n = 12) patients underwent evaluations at baseline and 4 weeks after having a GFD. Results: At baseline conditions, individuals diagnosed with CD exhibited prolonged colonic and intestinal transit times when compared to those with NCGS (p < 0.05). Following a 4-week GFD, CD patients experienced significant reductions in both intestinal and colonic transit times, along with enhanced small intestine contractility. NCGS individuals showed improvements in intestinal transit time and contractility with a GFD, although the colon exhibited no discernible effect. The GFD did not significantly impact intragastric, intestinal, or colonic pH. Conclusions: This study, employing WMC for the first time, provides novel insights into the positive effects of a GFD on intestinal and colonic transit, as well as contractility, in CD patients, and to a lesser extent, in those with NCGS.

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