Non‐Collagen Proteins in Bone

Termine, John D.

doi:10.1002/9780470513637.ch12

Cited by 36 publications

(33 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Like albumin, Fet-A is widely distributed in the extracellular space of virtually all vascularized tissues, and is therefore completely absent from avascular tissues such as cartilage. Mineralized bone, as well as dentin, represent the tissues in which Fet-A is considered as one of the most abundant non-collagenous proteins with a high affinity for the apatite mineral, which makes it probably a crucial factor for mineral metabolism [19,25]. Due to a rather large expression and the significant capacity for molecular interactions with several different ligands, it was assumed that Fet-A could mainly exert support and scavenging functions similarly to albumin, and would play a key role in several physiological processes ( Figure 1) [19].…”

Section: Role Of Fetuin-a In Physiological Processesmentioning

confidence: 99%

Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review

Bourebaba

Marycz

2019

JCM

View full text Add to dashboard Cite

Alpha 2-Heremans-Schmid glycoprotein, also known as fetuin-A (Fet-A), is a multifunctional plasma glycoprotein that has been identified in both animal and human beings. The protein is a hepatokine predominantly synthesized in the liver, which is considered as an important component of diverse normal and pathological processes, including bone metabolism regulation, vascular calcification, insulin resistance, and protease activity control. Epidemiological studies have already consistently demonstrated significant elevated circulating Fet-A in the course of obesity and related complications, such as type 2 diabetes mellitus, metabolic syndrome, and nonalcoholic fatty liver disorder (NAFLD). Moreover, Fet-A has been strongly correlated with many parameters related to metabolic homeostasis dysregulation, such as insulin sensitivity, glucose tolerance, circulating lipid levels (non-esterified free fatty acids and triglycerides), and circulating levels of both pro- and anti-inflammatory factors (C-reactive protein, tumor necrosis factor-α (TNF-α), and interleukin (IL)-6). Metabolic-interfering effects of Fet-A have thus been shown to highly exacerbate insulin resistance (IR) through blocking insulin-stimulated glucose transporter 4 (GLUT-4) translocation and protein kinase B (Akt) activation. Furthermore, the protein appeared to interfere with downstream phosphorylation events in insulin receptor and insulin receptor substrate signaling. The emerging importance of Fet-A for both diagnosis and therapeutics has therefore come to the attention of researchers and the pharmaceutical industry, in the prospect of developing new therapeutic strategies and diagnosis methods for metabolic disorders.

show abstract

Section: Role Of Fetuin-a In Physiological Processesmentioning

confidence: 99%

Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review

Bourebaba

Marycz

2019

JCM

View full text Add to dashboard Cite

show abstract

“…Found in the extra cellular matrix, examples include growth factors (TGF beta, PDGF, IGF-1, FGF-a, FGF-b and IL-1), bone sialoprotein, osteopontin, osteonectin, osteocalcin and proteins (fibronectin, vitronectin and laminin) [12]. Osteopontin mediates adhesion of osteoblasts and osteoclasts to the osteoid matrix [13]. Bone sialoprotein, osteonectin and osteocalcin are required for bone mineralisation [14-16].…”

Section: Bone Formationmentioning

confidence: 99%

An Update into the Application of Nanotechnology in Bone Healing

Brannigan

Griffin

2016

TOORTHJ

View full text Add to dashboard Cite

BackgroundBone differs from other organs in that it can regenerate and remodel without scar formation. There are instances of trauma, congenital bone disorder, bone disease and bone cancer where this is not possible. Without bone grafts and implants, deformity and disability would result.Human bone grafts are limited in their management of large or non-union fractures. In response, synthetic bone grafts and implants are available to the Orthopaedic Surgeon. Unfortunately these also have their limitations and associated complications.Nanotechnology involves the research, design and manufacture of materials with a grain size less than 100nm. Nano-phase materials follow the laws of quantum physics, not classical mechanics, resulting in novel behavioural differences compared to conventional counterparts.Methods:Past, present and future nanotechnology in bone healing literature is reviewed and discussed. The article highlights concepts which are likely to be instrumental to the future of nanotechnology in bone healing.Results:Nanotechnology in bone healing is an emerging field within Orthopaedic Surgery. There is a requirement for bone healing technologies which are biochemically and structurally similar to bone. Nanotechnology is a potential solution as the arrangement of bone includes nanoscopic collagen fibres and hydroxyapatite.This review centers on the novel field of nanotechnology in bone healing with discussion focusing on advances in bone grafts, implants, diagnostics and drug delivery.Conclusion:The concept of nanotechnology was first introduced in 1959. Current nanoproducts for bone healing include nano-HA-paste-ostim and nano-beta-tricalcium phosphate-Vitoss.Nanophase technologies are considered to be superior bone healing solutions. Limited safety data and issues regarding cost and mass scale production require further research into this exciting field.

show abstract

“…FGF, PDGF, TGF-␤, and several BMPs have been reported to enhance the differentiation and growth of osteoblasts. [256][257][258] Thus, release of these factors from the bone matrix provides a feedback mechanism to promote bone formation and attenuate bone resorption.…”

Section: Epithelial To Mesenchymal Transition (Emt) Of Prostate Cancementioning

confidence: 99%

Targeting Neuropilin-1 in Prostate Cancer Bone Metastasis

Wu¹

2011

View full text Add to dashboard Cite

Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number.

show abstract

Non‐Collagen Proteins in Bone

Cited by 36 publications

References 44 publications

Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review

Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review

An Update into the Application of Nanotechnology in Bone Healing

Targeting Neuropilin-1 in Prostate Cancer Bone Metastasis

Contact Info

Product

Resources

About