Non-conducting functions of potassium channels in cancer and neurological disease

The role of potassium ion channels in chronic sinusitis

“…Human genome sequencing has identified more than 80 potassium channel genes, which are mainly divided into four subgroups based on transmembrane topology and activated modes: voltage gated K + channels (Kv), inwardly rectified K + channels (Ki), two pore domain K + channels (K2P), and calcium-activated potassium channels (KCa) ( Figure 1 ) ( Sesti et al, 2023 ; Xia et al, 2023 ).…”

“…Kv consists of 6 transmembrane domains (TMDs, S1-S6 from the N-terminus) and 1 spiral pore domain (located between S5 and S6), the first 4 TMDs (S1-S4) form the voltage sensing domain (VSD, Figure 1 ). Kv family includes 12 channels: Kv 10 is the ether go (EAG) K + channel, Kv 11 is the human ether a go related gene (hERG) K + channel, and Kv 12 belongs to the EAG family ( Sesti et al, 2023 ; Xia et al, 2023 ). Kv 5, Kv 6, Kv 8, and Kv 9 are members of the electrically silent Kv subfamilies which must form functional heterotetramers with Kv 2 (Kv2/KvS) ( Bocksteins, 2016 )11.…”

“…Kv 5, Kv 6, Kv 8, and Kv 9 are members of the electrically silent Kv subfamilies which must form functional heterotetramers with Kv 2 (Kv2/KvS) ( Bocksteins, 2016 )11. Kv is involved in the generation of action potentials and synaptic transmission and maintains the normal electrophysiology of the heart and the nervous system ( Bocksteins, 2016 ; Sesti et al, 2023 ; Xia et al, 2023 ).…”

“…In recent years, the role of ion channels in regulating the mucosal barrier and inflammatory cell function has been increasingly recognized ( Pelletier and Savignac, 2018 ; Backaert et al, 2021 ; Deng et al, 2021b ). As the most widely distributed ion channels in the human body, potassium ion channels play a crucial role in the formation of excitable cell action potentials, neurotransmitter transmission, and electrical activity in the myocardium and skeletal muscles ( Sesti et al, 2023 ; Xia et al, 2023 ). In nonexcitable cells, increasing research has found that potassium ion channels can regulate cell volume, stretch, and intracellular calcium, and participate in proliferation, immune response, and hormone secretion, etc ( Sesti et al, 2023 ; Xia et al, 2023 ).…”

“…As the most widely distributed ion channels in the human body, potassium ion channels play a crucial role in the formation of excitable cell action potentials, neurotransmitter transmission, and electrical activity in the myocardium and skeletal muscles ( Sesti et al, 2023 ; Xia et al, 2023 ). In nonexcitable cells, increasing research has found that potassium ion channels can regulate cell volume, stretch, and intracellular calcium, and participate in proliferation, immune response, and hormone secretion, etc ( Sesti et al, 2023 ; Xia et al, 2023 ). However, there are only a few initial studies on the relationship between potassium channels and CRS.…”