Non-Contact High-Frequency Ultrasound Microbeam Stimulation: A Novel Finding and Potential Causes of Cell Responses

Qi, Luchao; Zhang, Qi; Tan, Yan; Lam, Kwok Ho; Zheng, Hairong; Qian, Ming

doi:10.1109/tbme.2019.2929008

Cited by 9 publications

(8 citation statements)

References 18 publications

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“…The elastic rendering of the focus is mainly blue. The research results of this group are also consistent with the literature report [ 6 ]. Ichou, Gauvin, and Faingold reported 2 cases of SAT diagnosed by puncture, of which 1 case showed only a small abnormal echo area on conventional ultrasound, but ultrasonic elastic imaging has obviously shown the increase of the hardness of the echo area.…”

Section: Literature Reviewsupporting

confidence: 92%

Diagnostic Value of Color Doppler Ultrasonography in Subacute Thyroiditis

et al. 2022

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In order to explore the clinical effect of color Doppler ultrasonography in the diagnosis of subacute thyroiditis, a method for the diagnosis of subacute thyroiditis by color Doppler ultrasonography was proposed. From November 2019 to November 2020, 90 patients with subacute thyroiditis in our hospital were selected as the experimental group; 90 healthy people were selected as the control group during the same period. Both groups were diagnosed by color Doppler ultrasonography and compared. The experimental results showed that patients with subacute thyroiditis showed mild to moderate enlargement of the involved thyroid gland, and local or diffuse inhomogeneous hypoechoic areas may appear in bilateral or unilateral thyroid glands: irregular edges, unclear boundaries, no "ball feel," mottled changes, and accompanied by tenderness. The blood flow signal around the hypoechoic area is rich, and the internal blood flow signal is less. There was no significant increase in the blood flow velocity of the superior thyroid artery on the affected side. Color Doppler ultrasound not only is simple, economical, and non-invasive but also has a good diagnostic accuracy for subacute thyroiditis, which can provide an important basis for clinical diagnosis and treatment and is worthy of popularization and application.

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Section: Literature Reviewsupporting

confidence: 92%

Diagnostic Value of Color Doppler Ultrasonography in Subacute Thyroiditis

et al. 2022

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“…Qi et al believed that the main treatment methods for RDS are conventional comprehensive treatment, pulmonary surfactant, and mechanical ventilation, and during mechanical ventilation, there is barotrauma and shear injury, which may lead to ventilator-related lung injury. In recent years, it has been found that, during mechanical ventilation, giving lung protection ventilation strategies can reduce ventilator-related lung injury, improve oxygenation, and improve lung compliance, including low tidal volume ventilation and lung recruitment strategies [ 9 ]. Njs et al believed that the strategy of lung recruitment is to give an appropriate pressure within a limited time, inflate as many collapsed alveoli as possible, and at the same time, keep the open alveoli open.…”

Section: Literature Reviewmentioning

confidence: 99%

[Retracted] Clinical Value and Imaging Features of Bedside High‐Frequency Ultrasound Imaging in the Diagnosis of Neonatal Pneumonia

Zhu¹,

Chen²,

Jiang³

2022

Contrast Media & Molecular Imaging

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The aim is to solve the problem of the urgent need of a nonradiation, noninvasive, and simple-to-operate diagnostic method for neonatal pneumonia that can indicate the severity of the disease and dynamically monitor the outcome of the disease. The authors propose a bedside high-frequency ultrasound technique based on methods for evaluation in the detection and treatment of neonatal pneumonia. The results obtained are as follows: the sensitivity of neonatal lung ultrasound in the diagnosis of neonatal pneumonia was 96.6%, the specificity was 93.3%, the positive predictive value was 93.5%, and the negative predictive value was 96.5%. The sensitivity of chest X-ray in the diagnosis of neonatal pneumonia was 93.3%. Compared with the lung ultrasound and chest X-ray in the diagnosis of neonatal pneumonia, the two had a good correlation. The neonatal respiratory score was positively correlated with the lung ultrasound score, and the higher the lung ultrasound score, the more severe the disease. The score decreased by 35% after 3 days of treatment and 68% after 7 days of treatment, indicating that the lung high-frequency ultrasound score can be very effective in characterizing the treatment situation. It has been demonstrated that the lung ultrasound can be used as an imaging method for the diagnosis of neonatal pneumonia. The higher the lung ultrasound score, the more severe the disease, and the lung ultrasound score was positively correlated with the disease severity. With dynamic monitoring of the lung ultrasound and the gradual improvement of clinical symptoms after treatment, the lung ultrasound score gradually decreased; therefore, the lung ultrasound can be used for re-examination of neonatal pneumonia to evaluate the treatment effect and guidance.

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“…The detection of the differences in cell response towards HFUMS could distinguish between non-cancerous and highly invasive cancer cells. Moreover, this kind of stimulation by US showed no impact on cell viability, displaying optimal parameters for potential applications of HFUMS as biosensors [5]. In addition to being a tool for diagnosis, HFUMS could assist in tumor treatment.…”

Section: Activation Of Ion Channels Applications In Oncology and Neur...mentioning

confidence: 93%

“…A significant difference in Ca 2+ influx was indeed observed following exposure to US at 193 MHz of human breast cancer or non-cancerous cells, and US of 200 MHz to endothelial cells (HUVEC) [40,41]. Likewise, another study found no impact of US at 50 MHz on human breast non-cancerous cells, but an increase in Ca 2+ influx, as a function of the invasiveness of human breast cancer cells [5]. Another class of cationic channels, the transient receptor potential (TRP) channel, could also play a part, but no significant activation by US was observed.…”

Section: Activation Of Ion Channels Applications In Oncology and Neur...mentioning

confidence: 93%

“…At low frequencies, a phenomenon called cavitation can create transient pores in the cell membranes and locally increase the delivery of therapeutic drugs through translocation [4]. At higher frequencies, transfection can be achieved without cavitation, facilitating gene or protein delivery with great application potential in oncology [5,6]. US can be triggered by the resonance of a whole bulk material (as shown in Figure 1A,B), or the resonance of the extreme surface of an elastic material (Figure 1C).…”

Section: Introductionmentioning

confidence: 99%

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Biological Effects and Applications of Bulk and Surface Acoustic Waves on In Vitro Cultured Mammal Cells: New Insights

et al. 2022

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Medical imaging has relied on ultrasound (US) as an exploratory method for decades. Nonetheless, in cell biology, the numerous US applications are mainly in the research and development phase. In this review, we report the main effects on human or mammal cells of US induced by bulk or surface acoustic waves (SAW). At low frequencies, bulk US can lead to cell death. Under specific intensities and exposure times, however, cell proliferation and migration can be enhanced through cytoskeleton fluidization (a reorganization of the actin filaments and microtubules). Cavitation phenomena, frequencies of resonance close to those of the biological compounds, and mechanical transfers of energy from the acoustic pressure could explain those biological outcomes. At higher frequencies, no cavitation is observed. However, USs of high frequency stimulate ionic channels and increase cell permeability and transfection potency. Surface acoustic waves are increasingly exploited in microfluidics, especially for precise cell manipulations and cell sorting. With applications in diagnosis, infection, cancer treatment, or wound healing, US has remarkable potential. More mechanotransduction studies would be beneficial to understand the distinct roles of temperature rise, acoustic streaming and mechanical and electrical stimuli in the field.

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Non-Contact High-Frequency Ultrasound Microbeam Stimulation: A Novel Finding and Potential Causes of Cell Responses

Cited by 9 publications

References 18 publications

Diagnostic Value of Color Doppler Ultrasonography in Subacute Thyroiditis

Diagnostic Value of Color Doppler Ultrasonography in Subacute Thyroiditis

[Retracted] Clinical Value and Imaging Features of Bedside High‐Frequency Ultrasound Imaging in the Diagnosis of Neonatal Pneumonia

Biological Effects and Applications of Bulk and Surface Acoustic Waves on In Vitro Cultured Mammal Cells: New Insights

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