Non-contrast-enhanced T&lt;sub&gt;1&lt;/sub&gt; Mapping of Dilated Cardiomyopathy: Comparison between Native T&lt;sub&gt;1&lt;/sub&gt; Values and Late Gadolinium Enhancement

Yanagisawa, Fumi; Amano, Yasuo; Tachi, Masaki; Inui, Kentaro; Asai, Kuniya; Kumita, Shin‐ichiro

doi:10.2463/mrms.mp.2017-0136

Cited by 13 publications

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“…Late gadolinium enhancement is valuable for diagnosis and risk stratification of dilated cardiomyopathy. 3 Recently, Yanagisawa et al 6 have shown that native T 1 mapping is able to depict the myocardial scarring without gadolinium injection. T 1 mapping is also useful for detecting diffuse myocardial fibrosis associated with dilated cardiomyopathy ( Fig.…”

Section: Clinical Application and Relevance Of Quantitative Myocardial Tmentioning

confidence: 99%

“…[1][2][3] LGE MRI provides binary contrast between scarred and unscarred tissues, while T 1 mapping is complementary to LGE because it can quantify the degree of myocardial fibrosis or edema. [4][5][6] As such, T 1 -weighted imaging techniques, including LGE using an inversion recovery sequence, contribute to cardiac MRI. Conversely, T 2 -weighted imaging is widely used for identification of the pathological status in many organs, because T 2 values are correlated with edema, cellular proliferation, and vessel densities.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Importance of Myocardial T2 Mapping and Texture Analysis

et al. 2021

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Late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) is valuable for diagnosis and assessment of the severity of various myocardial diseases owing to its potential to visualize myocardial scars. T 1 mapping is complementary to LGE because it can quantify the degree of myocardial fibrosis or edema. As such, T 1 -weighted imaging techniques, including LGE using an inversion recovery sequence, contribute to cardiac MRI. T 2 -weighted imaging is widely used to characterize the tissue of many organs. T 2 -weighted imaging is used in cardiac MRI to identify myocardial edema related to chest pain, acute myocardial diseases, or severe myocardial injuries. However, it is difficult to determine the presence and extent of myocardial edema because of the low contrast between normal and diseased myocardium and image artifacts of T 2 -weighted images and the lack of an established method to quantify the images. T 2 mapping quantifies myocardial T 2 values and help identify myocardial edema. The T 2 values are significantly related to the clinical symptoms or severity of nonischemic cardiomyopathy. Texture analysis is a postprocessing method to quantify tissue alterations that are reflected in the T 2 -weighted images. Texture analysis provides a variety of parameters, such as skewness, entropy, and grey-scale non-uniformity, without the need for additional sequences. The abnormal signal intensity on T 2 -weighted images or T 2 values may correspond to not only myocardial edema but also other tissue alterations. In this review, the techniques of cardiac T 2 mapping and texture analysis and their clinical relevance are described.

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Section: Clinical Application and Relevance Of Quantitative Myocardial Tmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Importance of Myocardial T2 Mapping and Texture Analysis

et al. 2021

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“…Extracellular volume fraction (ECV) or native T 1 value measurement is used to overcome this issue. [4][5][6][7][8] These quantitative MRI methods identify diffuse interstitial fibrosis related to hospitalization caused by heart failure, interstitial expansion associated with amyloidosis, and myocardial…”

Section: Introductionmentioning

confidence: 99%

“… 4 – 8 An important advantage of native T 1 mapping over LGE and ECV measurements is that no gadolinium-based contrast agents are needed. 6 , 7 …”

Section: Introductionmentioning

confidence: 99%

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Relationship between Measurement Errors in Myocardial T1 Mapping and Heart Rate

et al. 2020

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Purpose: Modified Look-Locker inversion recovery (MOLLI) using a 5s(3s)3s scheme is robust to tachycardia, but some errors are occasionally observed in myocardial T 1 mapping. We sought to evaluate the relationship between measurement errors in T 1 mapping and heart rate (HR) using a confidence map. Methods: We enrolled 69 male patients with normal native T 1 values of the septal myocardium measured by a 5s(3s)3s MOLLI. The degree of measurement errors in the septal myocardium was assessed by two independent observers on a confidence map using a 4-point scale: 0, no errors; 1, errors located on the myocardial contour; 2, errors extended into the myocardial contour; and 3, errors extended into the midwall. We compared the scores of measurement errors and the average, maximum, minimum or variability of the HR indicated during the MOLLI scan (iHR), image phases of MOLLI or left ventricular ejection fraction (LVEF). Results: Patients with score >1 for the septal myocardium had significantly lower minimum iHR than those with a score ≤1 (P < 0.01; 49.8 ± 10.1 vs. 59.6 ± 9.7 beat per min). Conclusion: The confidence map shows more measurement errors in patients with lower minimum iHR. The myocardial T 1 values should be measured carefully in patients with bradycardia during MOLLI scanning.

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Kardiale MRT bei nichtischämischen Kardiomyopathien

Lücke

Gutberlet

2022

Radiologie

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Zusammenfassung Hintergrund Die in Deutschland angewandte Einteilung der Kardiomyopathien geht auf die Klassifikation der Europäischen Gesellschaft für Kardiologie (ESC) von 2008 zurück. Dort werden sie nach ihrem Phänotyp unterteilt, so dass die Magnetresonanztomographie (MRT) in der Lage ist, die unterschiedlichen Kardiomyopathien zu differenzieren. Bildgebung und Differenzialdiagnostik Die Stärke der MRT ist es, anhand der Möglichkeiten der Gewebsdifferenzierung nichtischämische Kardiomyopathien von anderen Erkrankungen mit ähnlichen morphofunktionellen Aspekten zu differenzieren. So gelingt im Fall der dilatativen Kardiomyopathie (DCM) eine Differenzierung zur inflammatorischen DCM. Im Fall der hypertrophen Kardiomyopathie (HCM) kann analog zur Echographie eine obstruktive und nichtobstruktive Form differenziert werden, aber auch die Detektion einer Amyloidose oder eines Morbus Fabry ist möglich. Die Evaluation der rechtsventrikulären Funktion gelingt im Rahmen einer arrhythmogenen rechtsventrikulären Kardiomyopathie (ARVC) zuverlässig. Außerdem ist die MRT in der Lage, die charakteristische fettige Ersatzfibrose direkt nachzuweisen. Bei den seltenen restriktiven Kardiomyopathien kann sie die Restriktion nachvollziehen und z. B. mittels T1-, T2- und T2*-Mapping die Sphingolipid-Akkumulation im Myokard bei einem Morbus Fabry oder eine Eisenüberladung bei Hämochromatose nachvollziehen. Innovationen Die quantitativen Verfahren des parametrischen Mappings bieten die Möglichkeit eines Therapiemonitorings; die klinische Relevanz dieses Monitorings ist aber noch Gegenstand aktueller Forschung. Die unklassifizierten Kardiomyopathien können sich klinisch mit ähnlicher Symptomatik wie ischämische oder inflammatorische Erkrankungen präsentieren, so dass im Fall eines Myokardinfarkts ohne verschlossene Koronararterien („myocardial infarction without obstructive coronary arteries“, MINOCA) in der Herzkatheteruntersuchung die MRT ein entscheidendes diagnostisches Instrument ist, um die tatsächlich zugrundeliegende Erkrankung festzustellen. Gleichermaßen kann sie bei neuen Kardiomyopathien wie der Non-compaction-Kardiomyopathie der Wegbereiter für eine morphologische Krankheitsdefinition sein.

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Non-contrast-enhanced T<sub>1</sub> Mapping of Dilated Cardiomyopathy: Comparison between Native T<sub>1</sub> Values and Late Gadolinium Enhancement

Abstract: Non-contrast-enhanced T mapping can be used for assessment of myocardial fibrosis associated with DCM by using the appropriate threshold.

Cited by 13 publications

References 28 publications

Clinical Importance of Myocardial T<sub>2</sub> Mapping and Texture Analysis

Clinical Importance of Myocardial T<sub>2</sub> Mapping and Texture Analysis

Relationship between Measurement Errors in Myocardial T<sub>1</sub> Mapping and Heart Rate

Kardiale MRT bei nichtischämischen Kardiomyopathien

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