Non-Contrast-Enhanced Whole-Body Magnetic Resonance Imaging in the General Population: The Incidence of Abnormal Findings in Patients 50 Years Old and Younger Compared to Older Subjects

Cieszanowski, Andrzej; Maj, Edyta; Kulisiewicz, Piotr; Grudziński, Ireneusz P.; Jakoniuk-Glodala, Karolina; Chlipala-Nitek, Irena; Kaczynski, Bartosz; Rowiński, Olgierd

doi:10.1371/journal.pone.0107840

Cited by 57 publications

(60 citation statements)

References 46 publications

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“…The observation that patients with ECU signal changes on MRI tended to be older than those without ECU signal changes on MRI is consistent with other types of pathophysiology such as degenerative spinal disease and extra-spinal degenerative disease [5], TFCC abnormalities [6,16], lumbar spine abnormalities [7], cervical spine abnormalities [8], trapeziometacarpal arthrosis [17], rotator cuff abnormalities [18], and meniscal tears [19], among others. The ECU may accumulate pathological changes with time, most of which are asymptomatic.…”

Section: Discussionsupporting

confidence: 72%

Incidental Signal Changes in the Extensor Carpi Ulnaris on MRI

Kuntz

Janssen

Ring

2015

Hand (New York, N,Y.)

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Background Magnetic resonance imaging (MRI) commonly finds musculoskeletal abnormalities incidental to the reason for ordering the test. The purpose of this study was to determine if the prevalence of extensor carpi ulnaris (ECU) signal changes on MRI varies between patients undergoing upper extremity MRI for assessment of clinically suspected ECU tendinopathy and those undergoing upper extremity MRI for other indications. Our secondary null hypotheses were that the prevalence of ECU signal changes on MRI does not vary based on patient age or sex and that the prevalence of ECU signal changes on MRI does not vary among other indications for MRI. Methods We searched MRI reports of all patients undergoing MRI of the hand, wrist, or arm at our institution between 2001 and 2014 for signal changes in the ECU. The medical record was reviewed to determine the indication for the MRI and the presence of clinically suspected ECU tendinopathy. Results ECU signal changes (overall prevalence of 13 %) were more common in patients undergoing MRI for a working clinical diagnosis of ECU tendinopathy or ulnar-sided wrist pain compared to patients evaluated for nonspecific pain and other indications. Age was independently associated with ECU signal changes on MRI. MRI signal changes are uncommonly associated with symptomatic tendinopathy (low positive predictive value). Conclusions ECU signal changes on MRI are common and often asymptomatic.

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Section: Discussionsupporting

confidence: 72%

Incidental Signal Changes in the Extensor Carpi Ulnaris on MRI

Kuntz

Janssen

Ring

2015

Hand (New York, N,Y.)

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“…They usually have no symptoms and rarely need treatment. In a study conducted by Ciezanowski et al Prevalence of kidney cysts was 25.1% [16]. Prevalence of kidney cyst was 2.9% in the present study.…”

Section: Discussionsupporting

confidence: 54%

Incidental Findings of the Lumbar Spine at MRI in Patients Diagnosed with Discopathy

Sobhan¹

2016

IJMI

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Background and objectives: the present study is an attempt to investigate the prevalence and type of lumbar spinal MRI incidental findings in patients diagnosed with discopathy. Materials and Methods: This cross-sectional study was conducted from 26/09/2012 to 14/01/2013 on MRI findings of 444 patients clinically diagnosed with Discopathy and approved MRI reports. A Radiologist studied the MRI results in terms of single vertebral hemangioma, multiple vertebral hemangiomas, kidney cyst, liver cyst and Perineural cyst. Data were collected and analyzed through Fisher Exact test. Results: 73 patients (16%) out of a total of 444 patients (215 males (48.4%) and 229 females (51.6) with a mean age of 42 years and age range of 13 to 87 years), provided incidental findings. The frequency of single vertebral hemangioma, multiple vertebral hemangioma, kidney cysts, liver cysts and Perineural cyst was 31 cases (7.0%), 11 cases (2.5%), 13 cases (2.9%), 2 cases (0.5%) and 3 cases (0.7%) respectively. There was no significant correlation between the frequency distribution of findings in terms of sex (P-value = 0.08), but there was a significant correlation between the frequency distribution of findings in terms of age (P-value = 0.006). Conclusion: incidental findings are fairly common findings in the MRI of patients with discopathy. There is a significant correlation between the frequency distributions of these findings and the patients' age, however, no correlation was observed between these findings and patients' sex.

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“…The prevalence in other whole-body MRI studies of healthy populations ranged from 12.8% to 57.6% [15][16][17][18] . Since those studies used similar MRI sequences applied to similar tissue volumes, variations in prevalence are most likely to have arisen from differences in the definition of IFs, or in the age and other characteristics of the imaged populations.…”

Section: Discussionmentioning

confidence: 99%

Impact of detecting potentially serious incidental findings during multi-modal imaging

Gibson¹,

Littlejohns²,

Adamska³

et al. 2017

Wellcome Open Res

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There are limited data on the impact of feedback of incidental Background findings (IFs) from research imaging. We evaluated the impact of UK Biobank's protocol for handling potentially serious IFs in a multi-modal imaging study of 100,000 participants (radiographer 'flagging' with radiologist confirmation of potentially serious IFs) compared with systematic radiologist review of all images.: Brain, cardiac and body magnetic resonance, and dual-energy x-ray Methods absorptiometry scans from the first 1000 imaged UK Biobank participants were independently assessed for potentially serious IFs using both protocols. We surveyed participants with potentially serious IFs and their GPs up to six months after imaging to determine subsequent clinical assessments, final diagnoses, emotional, financial and work or activity impacts.: : Compared with systematic radiologist review, radiographer Conclusions flagging missed some serious diagnoses, but avoided adverse impacts for many participants with non-serious diagnoses. While systematic radiologist review may benefit some participants, UK Biobank's responsibility to avoid both unnecessary harm to larger numbers of participants and burdening of publicly-funded health services suggests that radiographer flagging is a justifiable approach in the UK Biobank imaging study. The potential scale of non-serious final diagnoses raises questions relating to handling IFs in other settings, such as commercial and public health screening.

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Non-Contrast-Enhanced Whole-Body Magnetic Resonance Imaging in the General Population: The Incidence of Abnormal Findings in Patients 50 Years Old and Younger Compared to Older Subjects

Cited by 57 publications

References 46 publications

Incidental Signal Changes in the Extensor Carpi Ulnaris on MRI

Incidental Signal Changes in the Extensor Carpi Ulnaris on MRI

Incidental Findings of the Lumbar Spine at MRI in Patients Diagnosed with Discopathy

Impact of detecting potentially serious incidental findings during multi-modal imaging

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