Non-contrast MRI for breast screening: preliminary study on detectability of benign and malignant lesions in women with dense breasts

Can Combined Screening of Ultrasound and Elastography Improve Breast Cancer Identification Compared with MRI in Women with Dense Breasts-a Multicenter Prospective Study

“…Moreover, the use of supplemental MRI screening in women with extremely dense breast tissue and normal results on mammography resulted in the diagnosis of significantly fewer interval cancers than mammography alone [24][25]. MRI has been considered the most sensitive screening modality for women with dense breasts [26]. In this study, MRI also performed well in differentiating breast nodules in dense breasts, exhibiting a higher sensitivity (98.2%) than US.…”

Quantitative Measurement of Breast Density Using Personalized 3D-Printed Breast Model for Magnetic Resonance Imaging

“…Breast density, a measure of dense fibroglandular tissue relative to non-dense fatty tissue, has been determined as an independent risk factor for developing breast cancer [ 1 , 2 , 3 , 4 ]. Previous studies have reported that the potential risk of breast cancer in women with dense breasts is three- to five-fold higher than in women with fatty breasts [ 5 , 6 , 7 ].…”

“…Previous studies have reported that the potential risk of breast cancer in women with dense breasts is three- to five-fold higher than in women with fatty breasts [ 5 , 6 , 7 ]. Recent developments in breast cancer screening have intensified the need for a standardized imaging protocol and/or measurement method for the evaluation of breast density predominantly for women at an elevated risk of developing breast cancer, such as those with high breast density [ 4 , 8 , 9 , 10 ]. A considerable amount of literature has been published on the assessment of breast density with several methods and algorithms proposed to segment and/or measure breast density using MRI datasets [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ].…”

“…Nevertheless, research has consistently shown that these methods/algorithms seem to have certain drawbacks, mostly due to the use of a semi-automatic approach or a high-level of dependency on user interaction. Likewise, numerous MR breast-imaging protocols have been applied to the screening and/or the assessment of breast density, ranging from contrast- to non-contrast-enhanced imaging with or without the implementation of fat-suppression techniques [ 3 , 4 , 8 , 9 , 10 , 20 , 21 , 22 , 23 , 24 , 25 ]. To date, there has been little consensus on the optimal MR breast-imaging protocol and measurement method for breast density screening and/or assessment, especially in the context of women with dense breast tissues.…”

“…The dynamic contrast-enhanced (DCE)-MRI technique has been widely used for the screening of women at high risk of breast cancer and has been included in standard clinical breast MRI protocols [ 4 , 8 ]. Despite its long clinical success, DCE-MRI has certain disadvantages, such as long scanning time, high cost, and potential harm caused by the contrast agent [ 4 , 26 ].…”