Non-contrast myocardial perfusion using a novel 4D magnetic resonance arterial spin labeling technique: Initial experience

Miyazaki, Mitsue; Zhou, Xiangzhi; Hoshino, Tsutomu; Yokoyama, Kenichi; Ishimura, Rieko; Nitatori, Toshiaki

doi:10.1016/j.mvr.2015.01.007

Cited by 13 publications

(14 citation statements)

References 23 publications

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“…12 Alternative ASL techniques have also been proposed to increase the sensitivity to myocardial perfusion. [13][14][15][16] In recent years, compressed sensing (CS) 17 has emerged as a technique for image acceleration. 18,19 CS exploits the ability to compress the signal provided that it is sparse in some transformable domain, such as the wavelet domain, thus enabling data acquisition with high undersampling factors.…”

Section: Introductionmentioning

confidence: 99%

Myocardial arterial spin labeling in systole and diastole using flow‐sensitive alternating inversion recovery with parallel imaging and compressed sensing

2020

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Quantitative myocardial perfusion can be achieved without contrast agents using flow-sensitive alternating inversion recovery (FAIR) arterial spin labeling. However, FAIR has an intrinsically low sensitivity, which may be improved by mitigating the effects of physiological noise or by increasing the area of artifact-free myocardium. The aim of this study was to investigate if systolic FAIR may increase the amount of analyzable myocardium compared with diastolic FAIR and its effect on physiological noise. Furthermore, we compare parallel imaging acceleration with a factor of 2 with compressed sensing acceleration with a factor of 3 for systolic FAIR. Twelve healthy subjects were scanned during rest on a 3 T scanner using diastolic FAIR with parallel imaging factor 2 (FAIR-PI2 D), systolic FAIR with the same acceleration (FAIR-PI2 S) and systolic FAIR with compressed sensing factor 3 (FAIR-CS3 S). The number of analyzable pixels in the myocardium, temporal signal-to-noise ratio (TSNR) and mean myocardial blood flow (MBF) were calculated for all methods. The number of analyzable pixels using FAIR-CS3 S (663 ± 55) and FAIR-PI2 S (671 ± 58) was significantly higher than for FAIR-PI2 D (507 ± 82; P = .001 for both), while there was no significant difference between FAIR-PI2 S and FAIR-CS3 S. The mean TSNR of the midventricular slice for FAIR-PI2 D was 11.4 ± 3.9, similar to that of FAIR-CS3 S, which was 11.0 ± 3.3, both considerably higher than for FAIR-PI2 S, which was 8.4 ± 3.1 (P < .05 for both). Mean MBF was similar for all three methods. The use of compressed sensing accelerated systolic FAIR benefits from an increased number of analyzable myocardial pixels compared with diastolic FAIR without suffering from a TSNR penalty, unlike systolic FAIR with parallel imaging acceleration.

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Section: Introductionmentioning

confidence: 99%

Myocardial arterial spin labeling in systole and diastole using flow‐sensitive alternating inversion recovery with parallel imaging and compressed sensing

2020

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“…Cardiac motion is minimized by using ECG triggering. To limit the effects of respiratory motion in FAIR ASL, breath‐hold strategies have been mostly suggested, which can be uncomfortable in clinical populations. Moreover, even when data are acquired during breath‐holds, generally multiple breath‐holds are required for averaging, which can lead to myocardial position displacements among image sets.…”

Section: Introductionmentioning

confidence: 99%

Optimal repetition time for free breathing myocardial arterial spin labeling

et al. 2019

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Arterial spin labeling (ASL) offers a noninvasive and repeatable measurement of tissue blood flow, but its application in the human heart is still challenging. The aim of this study was to improve the scan efficiency of flow-sensitive alternating inversion recovery (FAIR) ASL using a single inversion time. First, by evaluating a free breathing acquisition without navigators. Second, by shortening TR to acquire more ASL pairs.A FAIR ASL with balanced steady state free precession (bSSFP) readout was implemented at 3 T and tested in 14 healthy volunteers. Three cardiac-triggered ASL scans with different TRs were compared while maintaining a constant acquisition time.These scans were named by the trigger pulse (TP) that started each acquisition: every two (TP1), four (TP2) and six (TP3) cardiac cycles. Two studies were performed on different days to assess the reproducibility of TP2 and TP3 scans. Perfusion response during passive leg raising was also evaluated. Student t-test and nonparametric equivalent were computed for perfusion differences. Bland-Altman and coefficient of variation (CV) were calculated for the reproducibility assessment.Mean myocardial blood flow (MBF) values measured at rest were: 1.47 ± 0.91 ml/g/min (TP1), 1.95 ± 0.93 ml/g/min (TP2) and 1.94 ± 1.41 ml/g/min (TP3). Intrasession CV was 17.15% (TP2) and 24.17% (TP3) and intersession CV was 36.86% (TP2) and 18.38% (TP3). Mean MBF was found to increase with passive stress by 0.22 ± 0.41 ml/g/min for TP2 (P = 0.037).Mean MBF values were consistent with the literature, although in the high end of the normal range. The lower MBF values measured in TP1 scans are attributable to saturation of blood outside the slice because of shorter TR. Free breathing FAIR cardiac ASL without navigators is feasible. A TR of approximately four seconds (TP2) offers the best alternative with similar mean ASL and tSNR than longer TR acquisitions.

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“…In addition, there is a concern about the risks related to toxicities and deposition of GBCA in various tissues [4], particularly the brain [5,6]. Thus, non-contrast-enhanced MRA techniques, using spin-labeling with three-dimensional (3D) balanced steady-state free precession (bSSFP), have been developed and applied in many contexts [7][8][9][10]. A technique for renal artery assessment using 3D bSSFP has been reported as a safe and effective approach for the evaluation of RAS [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Comparison of axial and coronal acquisitions by non-contrast-enhanced renal 3D MR angiography using flow-in time-spatial labeling inversion pulse

Takahashi

Ohmoto-Sekine

Yoshida

et al. 2019

Magn Reson Mater Phy

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Objective We evaluated image quality differences between axial and coronal non-contrast-enhanced renal three-dimensional (3D) magnetic resonance angiography (MRA) acquisitions, using time-spatial labeling inversion pulse (Time-SLIP) with flow-in balanced steady-state free precession (bSSFP). Materials and methods Axial and coronal images were acquired in 128 subjects using non-contrast-enhanced 3D-MRA with Time-SLIP flow-in bSSFP on a clinical 1.5-T MRI system. Visualization of source and maximum intensity projection (MIP) images of renal arteries were compared between the axial and coronal acquisitions using a four-point scale. For quantitative analysis, vessel-to-background contrast ratios of aorta and renal arteries were calculated. Results Both acquisitions yielded similarly excellent quality. In source image evaluation, coronal acquisitions showed significantly more motion degradation (p < 0.01) than did axial acquisitions. In MIP image evaluation, coronal acquisitions yielded superior image quality, less motion degradation, and better visualization of the number of renal branches than did axial acquisition. The renal artery to background signal contrast was greater in coronal than in axial acquisitions (p < 0.01). Conclusion Coronal acquisition provides superior contrast between the renal arteries and background and allows more persistent visualization than axial acquisitions in non-contrast-enhanced MRA using flow-in bSSFP with Time-SLIP. First-line screening of renal non-contrast-enhanced MRA should involve coronal acquisition.

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Non-contrast myocardial perfusion using a novel 4D magnetic resonance arterial spin labeling technique: Initial experience

Cited by 13 publications

References 23 publications

Myocardial arterial spin labeling in systole and diastole using flow‐sensitive alternating inversion recovery with parallel imaging and compressed sensing

Myocardial arterial spin labeling in systole and diastole using flow‐sensitive alternating inversion recovery with parallel imaging and compressed sensing

Optimal repetition time for free breathing myocardial arterial spin labeling

Comparison of axial and coronal acquisitions by non-contrast-enhanced renal 3D MR angiography using flow-in time-spatial labeling inversion pulse

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