Non-covalent allosteric regulation of capsule catalysis

Abstract

External effector binding allosterically regulates the catalytic properties of a simple Pd2L4 capsule.

Design and Applications of Water-Soluble Coordination Cages

“…In many examples discussed below, the hydrophobic effect is key to enforcing the strong and selective guest binding necessary for the observed reactivity. This effect explains why many reports of catalytic coordination cages involve WSCCs, with notable exceptions. ,− Several early examples of WSCCs, such as Fujita’s M 6 L 4 octahedra of type 6 and Raymond’s [Ga III 4 L 6 ] 12– tetrahedra 10 , , have been especially fruitful in this regard.…”

Kinetic selection of Pd4L2 metallocyclic and Pd6L3 trigonal prismatic assemblies

“…We have previously seen a similar binding mode with C-1/C-2 and Ph 3 PO. 38 This provides further evidence that encapsulation is prohibited because of thermodynamic (i.e. requiring significant cage distortion) and/or kinetic (i.e.…”

Guest‐Induced Transformations in Metal‐Organic Cages

“…[21][22][23][24][25] The incorporation of chemicals within the well-enclosed cage interior promotes the stabilization, [26,27] protection, [28][29] and new reactivity of guest molecules, [21,30] these effects have found use in molecular recognition, [31][32][33] chemical sensing, [34][35][36][37] gas capture, [38][39][40][41][42][43] molecular separations, [44][45][46] drug delivery, [47][48][49][50][51] bioimaging [21,52,53] as well as the exploration of new catalysis pathways. [21,22,[54][55][56][57][58][59][60] All binding events also cause subtle structural host perturbations, with negligible effects in most cases. However, significant conformational adaptations [61][62][63]…”