Non-cytotoxic antibacterial silver–coumarin complex doped sol–gel coatings

Jaiswal, Swarna; Bhattacharya, Kunal; Sullivan, Maeve; Walsh, Maureen; Creaven, Bernadette S.; Laffir, Fathima; Duffy, Brendan; McHale, Patrick

doi:10.1016/j.colsurfb.2012.07.047

Cited by 27 publications

(24 citation statements)

References 39 publications

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“…The use of Ag(I) complexes as biocidal additives in hygienic coatings has been demonstrated by our previous work in which Ag(I) complexes of coumarin-3-carboxylates were successfully incorporated into sol-gel derived coatings. The thin-film coatings were found to be effective against MRSA and Enterobacter cloacae WT6 strains at low silver loadings (0.3% w/w) and were less toxic than coatings containing silver nitrate and showed potential for use in the clinical environment [16].…”

Section: Introductionmentioning

confidence: 99%

Isolation and characterisation of silver(I) complexes of substituted coumarin-4-carboxylates which are effective against Pseudomonas aeruginosa biofilms

et al. 2014

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a b s t r a c tA novel series of coumarin-4-carboxylate ligands (2a-2l), their Ag(I) complexes (3a-3l) together with a number of their phenanthroline adducts (4d, 4f and 4g) have been synthesised and characterised. The ligands were prepared by either acid or base hydrolysis of their corresponding esters or by demethylation of a methylated acid derivative. The esters (1a-1i) were synthesised by an aromatic electrophilic substitution reaction between the conjugate base of substituted phenols and a vinyltriphenylphosphonium salt. The novel series of Ag(I) carboxylate complexes were prepared by reaction of silver nitrate with the coumarin ligands in aqueous/alcohol solution. The Ag(I) phenanthroline adducts were prepared by reaction of the Ag(I) complex with 1,10-phenanthroline in aqueous/alcohol solution. A selection of complexes were screened for their in vitro antibacterial activity against Pseudomonas aeruginosa grown planktonically or as a biofilm as well as a number of other clinically important strains, Escherichia coli, MRSA and Staphylococcus aureus. The activity against the P. aeruginosa biofilm was found to be significantly greater than against the planktonic bacteria.

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Section: Introductionmentioning

confidence: 99%

Isolation and characterisation of silver(I) complexes of substituted coumarin-4-carboxylates which are effective against Pseudomonas aeruginosa biofilms

et al. 2014

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“…Thereafter growth accelerates exponentially up to a maximum growth rate before slowing and stopping (stationary period) so that a maximum colony count or asymptote (A) is reached. The characteristic shape of such curves become sigmoidal [31]. During the lag period, individual bacteria mature and grow, but…”

Section: Kinetic Measurement Of Bacterial Growthmentioning

confidence: 99%

Protective properties of functionalised tetrazine on an aerospace aluminium alloy (AA 2024-T3)

Jaiswal

Varma

Mutuma

et al. 2015

Materials Chemistry and Physics

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Environmental health concerns over conventional chromium based surface treatments on aluminium substrates are well known. Current research efforts have concentrated on developing protective technologies for multiple applications. Such properties would enable manufacturers to address both corrosion and bacterial threats in areas such as fuel tanks and delivery systems.The present study explores the anticorrosion properties of 1,2-dihydro 1, 2, 4, 5 tetrazine-3, 6-dicarboxylic acid (H2DCTZ) on a copper rich aerospace aluminum alloy (AA 2024-T3).Furthermore the antimicrobial activity of the tetrazine is evaluated against Gram-positive and Gram-negative bacteria, both capable of inducing corrosion. The protective action of the tetrazine was investigated at different concentrations in a chloride ion rich environment (3.5% (w/v) NaCl) utilising electrochemical impedance spectroscopy (EIS). Results over a 72 hour period proved that an optimum concentration was 500 ppm. FTIR and SEM elemental mapping of the surface confirmed the nitrogen rich tetrazine affinity for the copper rich intermetallic sites, through coordinate bonds, which delayed corrosion onset and reduced pit formation. Moderate antibacterial tetrazine activity was observed against Escherichia coli and 100% efficacy against Staphylococcus aureus at 250 ppm was achieved. The damage of the bacterial cell envelope at the critical concentrations (250 ppm) is proposed as a possible mechanism for antibacterial action.

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“…Besides, experimental and clinical studies support that Zr compounds are biocompatible and exhibit low toxicity [7,8]. A possible approach to design antimicrobial surfaces is to incorporate bioactive additives based on functionalized silica matrix [9,10]. These frameworks associated with metallic particles like silver or copper have been studied previously and used as antimicrobial fillers with acceptable results against fungal and bacterial strains [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Functionalized zirconia compounds as antifungal additives for hygienic waterborne coatings

Arreche

Igal

Bellotti

et al. 2019

Progress in Organic Coatings

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A B S T R A C TThe addition of silver (Ag) into the chemical synthesis of materials, transform them into materials technologically relevant to be used as antimicrobial additives. In this work, the sol-gel method was used to obtain materials based on silica and zirconia, with the inclusion of Ag. The solids were characterized by potentiometric titration, specific surface area (S BET ), X-Ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) and, the antifungal activity of the additives was assessed by agar plate inhibition against Chaetomium globosum and Alternaria alternata. In addition, the resistance to fungal growth on waterborne coatings was evaluated after the incorporation of the solids into paint formulation.Amorphous materials with different acidic and textural properties were obtained. Most of the tested solids showed antifungal activity at the highest concentration used, and the presence of Ag increased the percentage of inhibition. The mixed oxides Ag-additives improved the antifungal activity compare with the pure Ag-oxides (silica or zirconia). In this sense, a synergic effect between zirconia/silica and silver would be a promising result that would reduce the amount of silver in these bioactive materials. This work was performed as a preliminary study, in order to guide the selection of a suitable additive from a list of possible antifungal agents.

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Non-cytotoxic antibacterial silver–coumarin complex doped sol–gel coatings

Cited by 27 publications

References 39 publications

Isolation and characterisation of silver(I) complexes of substituted coumarin-4-carboxylates which are effective against Pseudomonas aeruginosa biofilms

Isolation and characterisation of silver(I) complexes of substituted coumarin-4-carboxylates which are effective against Pseudomonas aeruginosa biofilms

Protective properties of functionalised tetrazine on an aerospace aluminium alloy (AA 2024-T3)

Functionalized zirconia compounds as antifungal additives for hygienic waterborne coatings

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