Non-cytotoxic carbon nanocapsules synthesized via one-pot filling and end-closing of multi-walled carbon nanotubes

Martinčić, Markus; Vranic, Sandra; Pach, Elzbieta; Sandoval, Stefania; Ballesteros, Belén; Kostarelos, Kostas

doi:10.1016/j.carbon.2018.10.006

Cited by 18 publications

(26 citation statements)

References 75 publications

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“…These tubes were sealed under vacuum and placed in a tubular furnace, where an annealing step was carried out (1200 °C for 12 h). The annealing allowed the encapsulation of the metal halide into MWCNTs and ensured the end-closure of nanotubes, creating thus the carbon nanocapsules [15]. Samples were collected from silica ampoules and mixed together.…”

Section: Preparation Of Sm@mwcntsmentioning

confidence: 99%

Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy

Wang

Spinato

Klippstein

et al. 2020

Carbon

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Radiotherapy is a cancer treatment utilising high doses of ionizing radiation to destroy cancer cells.Our team has pioneered neutron activation of 152 Sm, filled and sealed into single-walled (SWCNTs) and multi-walled carbon nanotubes (MWCNTs), to create stable and high-dose radioactive carbon nanocapsules for cancer radiotherapy. In this work, MWCNTs filled with enriched 152 SmCl3 (Sm@MWCNTs) were sealed and irradiated, followed by surface functionalisation with an epidermal growth factor receptor (EGFR)-targeting antibody. Characterisation of functionalised Sm@MWCNTs was carried out using thermogravimetric analysis, gel electrophoresis and transmission electron microscopy. The organ biodistribution of the radioactive functionalised 153 Sm@MWCNTs and therapeutic efficacy were studied in an experimental melanoma lung metastatic tumour model in mice after intravenous injection. Quantitative biodistribution analyses showed high accumulation of 153 Sm@MWCNT-Ab in lung. Significant tumour growth reduction was induced by both treatments of 153 Sm@MWCNTs functionalised with or without the antibody after a single intravenous injection. Although EGFR targeting showed no improvement in therapeutic efficacy, reduced spleen toxicity and normal haematological profiles were obtained for both functionalised derivatives. The current study demonstrated the possibility of performing chemical functionalisation and antibody conjugation on radioactive nanocapsules post-irradiation for the preparation of targeted radiopharmaceuticals.

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Section: Preparation Of Sm@mwcntsmentioning

confidence: 99%

Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy

Wang

Spinato

Klippstein

et al. 2020

Carbon

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“…The temperature required to provoke the spontaneous closure of the CNT ends is diameter dependent, and high temperatures are needed to seal filled MWCNTs (ea. 1200 ' C) [29]. In contrast, when low temperature routes are employed, such as solution filling, the ends of the nanotubes remain opened.…”

Section: Selected Examples Of Confined Na Nocrystalsmentioning

confidence: 99%

“…6(a) shows a HRTEM image of a PbI 2 -NT@MWCNTs as prepared by high temperature filling. A large variety of materials have been shown to also coat the inner cavities of MWCNT forming single-layered inorganic nanotubes (SLINTs), namely PbI 2 [57,58], ZnI 2 [58,59], CeCl 3 [59], CeI 3 [59], TbCl 3 [59], GdCl 3 [29], SmCl 3 [29], BiI 3 [60], GdI 3 [61] and BiCl 3 [62]. The role that the temperature of treatment has on the grown nanostructures was investigated using ZnI 2 and MWCNTs [59].…”

Section: Selected Examples Of Confined Na Nocrystalsmentioning

confidence: 99%

Structure of inorganic nanocrystals confined within carbon nanotubes

Sandoval

Flahaut

2019

Inorganica Chimica Acta

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“…In case of MWCNTs, closing their ends by high temperature annealing is much more difficult and requires the formation of C-C bonds generating high curvature strain ( Mazzoni et al, 1999 ). Moreover, due to the presence of a larger cavity, a much higher energy and hence, much higher annealing temperatures than SWCNTs are necessary to induce the closing ( Martincic et al, 2019 ). Despite the later protocol demonstrated to be highly efficient for the formation of hermetically closed nanocapsules, a wide range of substances can be decomposed at high temperature and an alternative strategy for sealing up the ends of the nanotubes is required.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Fullerenes: A Versatile Approach for the Confinement and Release of Materials Within Open-Ended Multiwalled Carbon Nanotubes

Sandoval

2021

Front. Bioeng. Biotechnol.

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We have employed fullerenes as versatile agents to “cork” the open tips of multiwalled carbon nanotubes (MWCNTs), and as promoting species for the release of the inorganic material filled within the nanotubes’ cavities. High Z element compounds, namely, PbI2, ZnI2, and CeI3, were chosen to easily determine the presence of the filler inside the hosting nanotubes by transmission electron microscopy (TEM). Fullerenes can isolate inorganic nanostructures confined within the hollow cavities of MWCNTs, which allows the removal of the external material remnant after the filling. Otherwise, taking advantage of the affinity of fullerenes with selected solvents, we have confirmed the ability of the C60 molecules to promote the displacement of the inorganic guest from the host. We propose two different strategies to trigger the release, employing vapor and liquid phase treatments. The first protocol involves annealing filled MWCNTs in presence of fullerenes (to obtain C60PbI2@MWCNTs) and the subsequent washing of the sample in ethanol under mild conditions. On the other hand, the simultaneous introduction of the C60 molecules and the liberation of the guest are produced by a single step wet procedure; the latter being potentially useful when materials that are not stable at high temperatures are employed for filling.

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Non-cytotoxic carbon nanocapsules synthesized via one-pot filling and end-closing of multi-walled carbon nanotubes

Abstract: cytotoxic carbon nanocapsules synthesized via one-pot filling and end-closing of multi-walled carbon nanotubes. Carbon, (2019). 141.

Cited by 18 publications

References 75 publications

Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy

Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy

Structure of inorganic nanocrystals confined within carbon nanotubes

Encapsulation of Fullerenes: A Versatile Approach for the Confinement and Release of Materials Within Open-Ended Multiwalled Carbon Nanotubes

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