Effective Field Theory (EFT) extensions of the Standard Model are tools to compute observables e.g. cross sections with partonic center-of-mass energy √ ŝ as a systematically improvable expansion suppressed by a new physics scale M . If one is interested in EFT predictions in the parameter space where M < √ ŝ, concerns of self-consistency emerge, which can manifest as a violation of partial-wave unitarity. However, when we search for the effects of an EFT at a hadron collider with centerof-mass energy √ s using an inclusive strategy, we typically do not have access to the event-by-event value of √ ŝ. This motivates the need for a formalism that incorporates parton distribution functions into the partial-wave unitarity analysis. Developing such a framework and initiating an exploration of its implications is the goal of this work. Our approach opens up a potentially valid region of the EFT parameter space where M √ s. We provide evidence that there exist valid EFTs in this parameter space. The unitarity bounds are sensitive to the details of a given search, an effect we investigate by varying kinematic cuts.