Non-dietary correlates and determinants of plasma lutein and zeaxanthin concentrations in the Irish population

Moran, Rachel; Nolan, John M.; Stack, Jim; O’Halloran, Aisling; Feeney, Joanne; Akuffo, Kwadwo Owusu; Kenny, Rose Anne; Beatty, Stephen

doi:10.1007/s12603-016-0729-7

Cited by 14 publications

(13 citation statements)

References 61 publications

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“…Second, it is known that obesity results in increased oxidative stress and consequently lower MP. Finally, education has been clearly shown to be a predictor of MP as it is likely related to nutrition and lifestyle habits 46…”

Section: Discussionmentioning

confidence: 99%

Standardizing the Assessment of Macular Pigment Using a Dual-Wavelength Autofluorescence Technique

Green

Bernstein

Curcio

et al. 2019

Trans. Vis. Sci. Tech.

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Purpose: It is essential to have an appropriate measure to assess macular pigment (MP) that can provide an accurate, valid, and reliable representation of the MP within the macula. The aim of this study was to describe and introduce MP optical volume (MPOV) as an optimal value for reporting MP. Methods: Three hundred ninety-three subjects were analyzed using the Heidelberg Spectralis with the investigational MP optical density (MPOD) module to measure MPOV and MPOD at four foveal eccentricities (0.238, 0.518, 0.988, 1.768 [78 as reference point]). Lutein (L) and zeaxanthin (Z) dietary intake and serum concentrations were evaluated. Results: MPOV mean was 5094 (95%CI, 4877-5310); range: 527 to 10,652. MPOV was inversely correlated with body mass index and positively correlated with education (r ¼ À0.156, P ¼ 0.002 and r ¼ 0.124, P ¼ 0.014, respectively). Serum concentrations of L and Z were positively correlated with MPOV (r ¼ 0.422, P , 0.001 and r ¼ 0.285, P , 0.001, respectively). MPOV was positively correlated to MPOD at all measured eccentricities, with the strongest agreement at 1.768 (r ¼ 0.906, P , 0.001). Serum concentrations of L and Z, BMI, education, and age (P , 0.001) were found to be significant predictors of MPOV. Conclusions: The Spectralis MPOV measurement provided a comprehensive and detailed evaluation of the MP profile. The Spectralis MPOV should be considered a preferred metric for the assessment of MP.

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Section: Discussionmentioning

confidence: 99%

Standardizing the Assessment of Macular Pigment Using a Dual-Wavelength Autofluorescence Technique

Green

Bernstein

Curcio

et al. 2019

Trans. Vis. Sci. Tech.

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“…Details of the extraction procedures and HPLC analysis that we used have been previously described. 26 …”

Section: Plasma L and Z Assessmentmentioning

confidence: 99%

The Relationship Between Plasma Concentrations of Lutein and Zeaxanthin with Self-Reported and Actual Prevalence of AMD in an Irish Population-Based Sample

Moran

Beatty

Stack

et al. 2017

Current Eye Research

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Purpose: To investigate plasma lutein (L) and zeaxanthin (Z) concentrations with grading-confirmed and self-reported prevalence of age-related macular degeneration (AMD). Material and methods: Data collected from a nationally representative prospective cohort study of community-dwelling adults aged 50 years and over in the Republic of Ireland. Participants underwent a computer-assisted personal interview and a center-based health assessment. Plasma concentrations of L and total Z (Z and meso-zeaxanthin [MZ]) were measured by high performance liquid chromatography, and retinal photographs were graded using a version of the AMD International Classification and Grading System. Consumption of supplements containing L and/or Z and/or MZ was recorded as supplement use. Four groups were identified: Group 1 (n = 24): AMD-afflicted and correctly aware; Group 2 (n = 264): AMD-afflicted but unaware; Group 3 (n = 41): AMD-free and incorrectly believed that they were afflicted with the condition; Group 4 (n = 4094): AMD-free and correctly self-reported absence of AMD. Results: Of 4,423 participants with plasma concentrations of L and Z and gradable retinal photographs, 288 (6.5%) were afflicted with AMD, and 65 (1.5%) self-reported AMD. Controlling for family history and age, the relationship between grading-confirmed AMD and plasma L was positive and significant (p < 0.001). Mean plasma concentrations of L in Group 2 (mean = 0.2162 ± 0.132 µmol) and Group 4 (mean = 0.2040 ± 0.121 µmol/L) were significantly lower than Group 1 (mean = 0.4691 ± 0.0.372 µmol/L) and Group 3 (mean = 0.3176 ± 0.0.235 µmol/L). Supplement use was reported by 41.7% and 17.1% of participants in Groups 1 and 3, respectively, but only 2.7% and 1.9% of participants in Groups 2 and 4, respectively. Conclusion: A belief that one suffers from AMD, whether justified or not, is associated with supplement use and with higher plasma concentrations of L. ARTICLE HISTORY

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“…Besides dietary carotenoid intake, circulating carotenoid concentrations are also affected by age, physical activity, smoking and alcohol consumption (14)(15)(16)(17) . In addition, obesity (18) and low total LDL-and HDL-cholesterol concentrations (18,19) have been associated with lower circulating carotenoid concentrations. A sex difference is also noted in circulating carotenoid concentrations in women displaying higher concentrations compared with men (15,(17)(18)(19)(20) .…”

mentioning

confidence: 99%

“…In addition, obesity (18) and low total LDL-and HDL-cholesterol concentrations (18,19) have been associated with lower circulating carotenoid concentrations. A sex difference is also noted in circulating carotenoid concentrations in women displaying higher concentrations compared with men (15,(17)(18)(19)(20) . Therefore, the aim of the present study was to identify the correlates of plasma carotenoid concentrations among men and women and investigate whether variations in physical and metabolic parameters as well as dietary carotenoid intake contribute to the higher plasma carotenoid concentrations in women compared with men.…”

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confidence: 99%

Correlates of the difference in plasma carotenoid concentrations between men and women

et al. 2018

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Health professionals consider the evaluation of eating habits to be challenging, given the potential biases of dietary questionnaires based on self-reported data. Circulating carotenoid concentrations are reliable biomarkers of dietary carotenoid intake and could be useful in the validation of dietary assessment tools. However, there is a sex difference in circulating carotenoids, with women displaying higher concentrations compared with men independent of intake. The aim of the present study was to identify the correlates of plasma carotenoid concentrations among men (n155) and women (n110) enrolled in six fully controlled dietary interventions with varying dietary carotenoid intakes. We looked at the associations of post-intervention fasting plasma carotenoid concentrations (α-carotene,β-carotene,β-cryptoxanthin, lutein, lycopene and zeaxanthin) with physical and metabolic characteristics. We found that increased body weight (r–0·47,P<0·0001) and waist circumference (r–0·46,P<0·0001) were associated with lower plasma total carotenoid concentrations, while elevated plasma LDL-cholesterol (r0·49,P<0·0001) and HDL-cholesterol (r0·50,P<0·0001) concentrations were correlated with higher total carotenoids in plasma. Women had significantly higher plasma total carotenoid concentrations compared with men, despite significantly lower dietary carotenoid intake. Adjustment of circulating carotenoid concentrations for plasma HDL-cholesterol eliminated sex difference in plasma carotenoid concentrations. Our results suggest that physical characteristics as well as plasma lipids are associated with circulating carotenoid concentrations and that these variables should be taken into account when using plasma carotenoids as biomarkers for food intake in men and women.

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Non-dietary correlates and determinants of plasma lutein and zeaxanthin concentrations in the Irish population

Cited by 14 publications

References 61 publications

Standardizing the Assessment of Macular Pigment Using a Dual-Wavelength Autofluorescence Technique

Standardizing the Assessment of Macular Pigment Using a Dual-Wavelength Autofluorescence Technique

The Relationship Between Plasma Concentrations of Lutein and Zeaxanthin with Self-Reported and Actual Prevalence of AMD in an Irish Population-Based Sample

Correlates of the difference in plasma carotenoid concentrations between men and women

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