Non-dioxin-like PCBs inhibit [3H]WIN-35,428 binding to the dopamine transporter: A structure–activity relationship study

Wigestrand, Mattis B.; Stenberg, Mia; Walaas, S. Ivar; Fonnum, Frode; Andersson, Patrik L.

doi:10.1016/j.neuro.2013.07.005

Cited by 26 publications

(22 citation statements)

References 43 publications

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“…In addition to Σ PCBs, we also assessed interaction by the sum of 12 PCB congeners with anti-estrogenic/dioxin-like properties (i.e., IUPAC #s 77, 81, 105, 114, 118, 123, 126, 156, 157, 167, 169 and 189 (Cooke et al, 2001, Van den Berg et al, 2006, Wolff et al, 1997)), the sum of seven PCB congeners with estrogenic properties in vivo or in vitro (i.e., IUPAC #s 52, 77, 95, 99, 101, 110 and 153 (Cooke et al, 2001)), the sum of thyroid active congeners likely to compete for binding to serum TBPs (i.e., IUPAC #s 28, 52, 60, 74, 77, 95, 99, 101, 105, 114, 118, and 126 (Bloom et al, 2014; Chauhan et al, 2000)), and the sum of non-dioxin-like/ortho- PCB congeners that may inhibit dopamine transporter (i.e., IUPAC #s 28, 52, 74, 99, 101, 110, 118, 138, 153, and 180 (Wigestrand et al, 2013)). We reported individual and joint effects for models with p-value (p) < significant product terms (Knol et al, 2009).…”

Section: Methodsmentioning

confidence: 99%

Perfluoroalkyl substances and thyroid function in older adults

Shrestha

Bloom

Yucel

et al. 2015

Environment International

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Current understanding of the thyroid disruptive properties of perfluoroalkyl substances (PFASs), particularly in aging populations, is limited. The objectives of this study were to (i) assess associations between thyroid function, as measured by serum thyrotropin (thyroid stimulating hormone, TSH), free thyroxine (fT4), total thyroxine (T4), and total triiodothyronine (T3), and serum perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in an aging population and (ii) determine if other persistent organic pollutants with thyroid disruptive properties including polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) modify such associations. We conducted a cross-sectional study of 87 men and women 55 to 74 years of age, without clinically-diagnosed thyroid disease, who resided in upper Hudson River communities in New York. Geometric means (standard deviations) of serum PFOS and PFOA were 31.6 (1.7) ng/mL and 9.17 (1.72) ng/mL, respectively. Multivariable linear regression analyses indicated that one interquartile range difference in PFOS corresponded to 4% and 9% increases in fT4 and T4 respectively. We detected statistical interactions between PFOA and age for effects on fT4 and T4; joint increases in PFOA and age were associated with increases in fT4 and T4, of 3% and 7%, respectively. We also detected statistical interactions between PFOS and total PCBs for the effect on T3 and between PFOA and total PBDEs for the effect on TSH. Our results suggest that PFASs are associated with subtle alterations in thyroid hormone levels in this population, and that these associations are likely to vary by age, and levels of PCBs and PBDEs.

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Section: Methodsmentioning

confidence: 99%

Perfluoroalkyl substances and thyroid function in older adults

Shrestha

Bloom

Yucel

et al. 2015

Environment International

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“…Significant hyperactivity and increased general arousal has been reported in Drosophila administered methamphetamine, a dopamine transporter inhibitor, and in fmn , a Drosophila dopamine transporter mutant (Andretic et al 2005; Kume et al 2005). Given that PCBs, including those present in Aroclor 1254, inhibit the mammalian dopamine transporter (Wigestrand et al 2013), it is possible that Aroclor 1254 could also block dopamine reuptake in the honeybee. An increase in dopaminergic transmission is consistent with hyperactivity in vertebrates and in invertebrates (Andretic et al 2005; Puhl and Mesce 2008; Sawin et al 2000; Zhuang et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Spontaneous honeybee behaviour is altered by persistent organic pollutants

et al. 2016

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The effect of environmental pollutants on honeybee behaviour has focused mainly on currently used pesticides. However, honeybees are also exposed to persistent organic pollutants (POPs). The aim of this laboratory based study was to determine if exposure to sublethal field-relevant concentrations of POPs altered the spontaneous behaviour of foraging-age worker honeybees. Honeybees (Apis mellifera) were orally exposed to either a sublethal concentration of the polychlorinated biphenyl (PCB) mixture Aroclor 1254 (100 ng/ml), the organochlorine insecticide lindane (2.91 ng/ml) or vehicle (0.01% DMSO, 0.00015% ethanol in 1M sucrose) for 1–4 days. The frequency of single event behaviours and the time engaged in one of four behavioural states (walking, flying, upside down and stationary) were monitored for 15 min after 1, 2, 3 and 4 days exposure. Exposure to Aroclor 1254 but not lindane increased the frequency and time engaged in honeybee motor activity behaviours in comparison to vehicle. The Aroclor 1254—induced hyperactivity was evident after 1 day of exposure and persisted with repeated daily exposure. In contrast, 1 day of exposure to lindane elicited abdominal spasms and increased the frequency of grooming behaviours in comparison to vehicle exposure. After 4 days of exposure, abdominal spasms and increased grooming behaviours were also evident in honeybees exposed to Aroclor 1254. These data demonstrate that POPs can induce distinct behavioural patterns, indicating different toxicokinetic and toxicodynamic properties. The changes in spontaneous behaviour, particularly the PCB-induced chronic hyperactivity and the associated energy demands, may have implications for colony health.

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“…These effects could be the result of PCB-induced disruptions in synthesis [90], reuptake of DA from the synapse via dopamine transporter (DAT) competitive inhibition [91,92], or packaging of DA into vesicles by vesicular monoamine transporter [93]. More recent studies support the striatal findings, as PCB 180 increased basal extracellular DA in ventral striatum in male and female adult rats [67], and NDL PCBs inhibited DAT binding in male rat synaptosomes in vitro [87, 94]. Adult exposure to A1254 also reduced TH and DAT levels in the striatum in male mice [95].…”

Section: Effects Of Developmental Pcb Exposure On Social Behavior Andmentioning

confidence: 99%

Endocrine-disrupting actions of PCBs on brain development and social and reproductive behaviors

Bell

2014

Current Opinion in Pharmacology

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Polychlorinated biphenyls are among the most well-studied endocrine-disrupting chemicals (EDCs) for their neurobehavioral effects, especially neurodevelopment and cognitive performance. In addition, past research has demonstrated effects of PCBs on circulating hormones and associated changes in reproductive behaviors. This article will focus on recent advances that have been made in characterizing developmental PCB effects on reproductive function, broader social and affective behaviors, and the neuroendocrine mechanisms behind such changes. In general, PCBs seem to inhibit reproductive function by suppressing multiple aspects of the associated hypothalamic circuitry. Additionally, PCBs may also reduce motivation for social behaviors and induce depressive-like symptoms via overall reductions in dopaminergic and glutamatergic functions in the limbic system. However, more work with human-relevant exposure paradigms is needed to fully support these conclusions.

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Non-dioxin-like PCBs inhibit [3H]WIN-35,428 binding to the dopamine transporter: A structure–activity relationship study

Cited by 26 publications

References 43 publications

Perfluoroalkyl substances and thyroid function in older adults

Perfluoroalkyl substances and thyroid function in older adults

Spontaneous honeybee behaviour is altered by persistent organic pollutants

Endocrine-disrupting actions of PCBs on brain development and social and reproductive behaviors

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