Non-dipping status and selected adipokines concentration in children with primary arterial hypertension

Jędzura, Agnieszka; Adamczyk, Piotr; Bjanid, Omar; Świętochowska, Elżbieta; Roszkowska-Bjanid, Dagmara; Baraniecka, Anna; Banaszak, Beata; Plesiński, Krzysztof; Morawiec-Knysak, Aurelia; Ziora, Katarzyna; Szczepańska, Maria

doi:10.1080/10641963.2017.1324474

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…In the group of children and adolescents with normalweight hypertension, the correlation between ghrelin, leptin and adiponectin and anthropometrical parameters has also been found. In a recent study, leptin was shown to correlate with blood pressure, but this was not confirmed in our study [32]. However, ghrelin and adiponectin have been confirmed as cardiovascular markers in normal-weight hypertensive patients, which has not been proven in children until now, although this correlation has been found in adult patients [36].…”

Section: Discussioncontrasting

confidence: 91%

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The associations between some biological markers, obesity, and cardiovascular risk in Slovenian children and adolescents

2020

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Introduction: The occurrence of cardiovascular diseases and metabolic disorders steadily increases with the body mass index (BMI). Since the latter is not the best and earliest indicator of obesity and cardiovascular risk, the aim of the study was to evaluate some potential biological markers that would allow us to detect children and adolescents at higher risk at an early stage. Methods: A sample of 330 children and adolescents were included in the study and divided into four groups: obese patients with hypertension, normal-weight patients with hypertension, patients with mildly elevated lipids and a control group of healthy children and adolescents. Some clinical parameters (age, body weight, body height, BMI, waist circumference, hip circumference, blood pressure), biochemical parameters (glucose, total cholesterol, triglycerides, HDL, LDL, apolipoprotein A1, homocysteine) and biological markers of obesity (ghrelin, adiponectin, leptin) were evaluated. Results: Ghrelin and adiponectin were found to have a strong negative statistically significant correlation with BMI in all three observed groups (p < 0.001), but not in the control group (p = 0.053 and p = 0.316, respectively). In addition, leptin had a strong positive statistically significant correlation with BMI in all four groups (p < 0.001 for the research groups, p = 0.009 for the controls). In the group of obese patients with hypertension, statistically significant differences in all three markers of obesity were found in comparison to the control group (p < 0.001 for all markers). In the group of patients with mildly elevated lipids, ghrelin and leptin were significantly different (p = 0.002 and p < 0.001, respectively). In the group of normal-weight hypertensive patients, only values of ghrelin were different compared to the control group (p = 0.001). Conclusion: In the research groups, significant differences were found in clinical, biochemical and biological parameters compared to the control group. The observed biological markers of obesity are useful early markers for identifying groups of patients that are at cardiovascular risk.

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Section: Discussioncontrasting

confidence: 91%

“…In the present study, their observed correlation with systolic blood pressure indicates their role in hypertension risk. Recently, leptin has been found to play a role in obesity-related hypertension [32,33] as has adiponectin in adult men [34].…”

Section: Discussionmentioning

confidence: 99%

The associations between some biological markers, obesity, and cardiovascular risk in Slovenian children and adolescents

2020

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“…Varda et al observed in infants and toddlers from 2 to 30 months old a less pronounced night dip of only 5.4% on average [42]. A recent study observed a close relationship between non-dippers and BMI with children with primary hypertension and overweight or obesity showing a lack of decline of nocturnal blood pressure values [43]. Unfortunately, that study lacks information on GA or birth weight.…”

Section: Discussionmentioning

confidence: 99%

Kidney volume, kidney function, and ambulatory blood pressure in children born extremely preterm with and without nephrocalcinosis

et al. 2019

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BackgroundReduced kidney volume (KV) following prematurity is a proxy for reduced nephron number and is associated with the development of hypertension and end-stage renal disease in adults. We investigated whether extreme prematurity affects KV, function, and blood pressure in school-aged children and if nephrocalcinosis (NC) developed during the neonatal period had additional effects.MethodsWe investigated 60 children at a mean age of 7.7 years: 20 born extremely preterm (EPT < 28 weeks gestational age with NC (NC+)), 20 born EPT without NC (NC−), and 19 born as full-term infants (control). We measured KV by ultrasound, collected blood and urine samples to evaluate renal function, and measured office and 24-h ambulatory blood pressure (ABPM).ResultsChildren born EPT had significantly smaller kidneys (EPT (NC+ NC−) vs control (estimated difference, 11.8 (CI − 21.51 to − 2.09 ml), p = 0.018) and lower but normal cystatin C–based glomerular filtration rate compared with control (estimated difference, − 10.11 (CI − 0.69 to − 19.5), p = 0.035). KV and function were not different between NC+ and NC− groups. Change in KV in relation to BSA (KV/BSA) from the neonatal period to school age showed significantly more EPT children with neonatal NC having a negative evolution of KV (p = 0.01). Blood pressure was normal and not different between the 3 groups. Fifty percent of EPT had a less than 10% day-to-night decline in ABPM.ConclusionsKidney growth and volume is affected by EPT birth with NC being a potential aggravating factor. Circadian blood pressure regulation seems abnormal in EPT-born children.

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“…Strengths of this study are the availability of comprehensive perinatal, neonatal, maternal, infant, and early childhood data; serial anthropometric data; and comprehensive assessment including BP at 6 to 7 years of age. Limitations include the lack of a term control population; no data on maternal prepregnancy weight, weight gain in pregnancy, dietary intake, renal findings, or BP at earlier ages 55,56 ; those lost to follow-up had higher rates of public insurance, cesarean delivery, and bronchopulmonary dysplasia, creating a possible bias; and a single visit with duplicate measurements of BP.…”

Section: Discussionmentioning

confidence: 99%

High Blood Pressure at Early School Age Among Extreme Preterms

et al. 2018

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Non-dipping status and selected adipokines concentration in children with primary arterial hypertension

Cited by 8 publications

References 26 publications

The associations between some biological markers, obesity, and cardiovascular risk in Slovenian children and adolescents

The associations between some biological markers, obesity, and cardiovascular risk in Slovenian children and adolescents

Kidney volume, kidney function, and ambulatory blood pressure in children born extremely preterm with and without nephrocalcinosis

High Blood Pressure at Early School Age Among Extreme Preterms

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