Non-directed altruistic living liver donation: Evaluation and outcomes

Lodge, Peter; Jeffery, J.; McGoohan, K.; Attia, Magdy; Toogood, Giles J.; Vijayanand, D.; Upasani, V.; Dillon, John; Moore, Joanna; Chimakurthi, Chenchu; Hosker, C.; Hidalgo, Ernest

doi:10.1016/j.hpb.2020.04.361

Cited by 1 publication

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“…The reluctance to accept unspecified living donors likely results from multiple sources, including unresolved ethical concerns, legal barriers, providers' scepticism of donors' motivations, the logistical complexity in developing and maintaining anonymous live organ donor programs, as well as concerns regarding regulatory ramifications and potential for commercialization [9,10]. The limited literature available report quantitative data on the characteristics and outcomes of unspecified donors and have demonstrated comparable quality of life and psychosocial benefits among this group of living donors [11][12][13][14]. Nevertheless, the lack of in-depth understanding of the profile, motivations, and experiences of unspecified donors continues to hinder the expansion of anonymous living organ donor programs across transplant centres.…”

Section: Introductionmentioning

confidence: 99%

A qualitative systematic review of anonymous/unspecified living kidney and liver donors’ perspectives

Lim

Chan

et al. 2022

PLoS ONE

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Objectives & background Anonymous live organ donors or unspecified donors are individuals willing to be organ donors for any transplant recipient with whom they have no biological or antecedent emotional relationship. Despite excellent recipient outcomes and the potential to help address organ scarcity, controversy surrounds the unconditional act of gifting one’s organs to an unrelated recipient. This qualitative systematic review provides insights into the first-hand experiences, motivations, and challenges that unspecified donors face. Methods A systematic search was conducted on Medline, Embase, CINAHL, PsycINFO, and Web of Science database for qualitative literature regarding unspecified living donors’ motivations and experiences in liver and kidney transplantation. An inductive thematic analysis was conducted to generate themes and supportive subthemes. Results 12 studies were included. The four major themes were (i) motivations, (ii) perception of risks, (iii) donor support, and (iv) benefits of donation. Unspecified donors demonstrated a deep sense of social responsibility but tended to underestimate health risks in favour of benefits for recipients. Despite the lack of emotional support from family and friends, the decision to donate was a resolute personal decision for donors. Majority benefitted emotionally and did not express regret. Conclusion This qualitative review bridges the gap in literature on unspecified living donor psychology and provides a comprehensive understanding of the decision-making matrix and experiences of donors.

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