Non-Edible Plants as an Attractive Source of Compounds with Chemopreventive Potential

Ji, Seungwon; Orlikova, Barbora; Diederich, Marc

doi:10.15430/jcp.2014.19.1.1

Cited by 14 publications

(12 citation statements)

References 21 publications

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“…Chemoprevention is the use of such agents which have potential to inhibit, reverse or retard tumorigenesis (Surh 2003). Use of natural plant products for cancer chemoprevention has gained considerable attention over the last few years (Surh 2003;Amin et al 2009;Ji et al 2014). Diet of people varies from place to place because of different lifestyles.…”

Section: Introductionmentioning

confidence: 99%

Phytoconstituents as apoptosis inducing agents: strategy to combat cancer

et al. 2015

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Advancement in the field of cancer molecular biology has aided researchers to develop various new chemopreventive agents which can target cancer cells exclusively. Cancer chemopreventive agents have proficiency to inhibit, reverse and delay process of carcinogenesis during its early and later course. Chemopreventive agents can act as antioxidative, antimutagenic/antigenotoxic, anti-inflammatory agents or via aiming various molecular targets in a cell to induce cell death. Apoptosis is a kind of cell death which shows various cellular morphological alterations such as cell shrinkage, blebbing of membrane, chromatin condensation, DNA fragmentation, formation of apoptotic bodies etc. Nowadays, apoptosis is being one of the new approaches for the identification and development of novel anticancer therapies. For centuries, plants are known to play part in daily routine from providing food to management of human health. In the last two decades, diverse phytochemicals and various botanical formulations have been characterized as agents that possess potential to execute cancer cells via inducing apoptosis. Data obtained from the research carried out globally pointed out that natural products are the potential candidates which have capability to combat cancer. In the present review, we surveyed literature on natural products which throws light on the mechanism through which these phytochemicals induce apoptosis in cancer cells.

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Section: Introductionmentioning

confidence: 99%

Phytoconstituents as apoptosis inducing agents: strategy to combat cancer

et al. 2015

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“…Cancer chemoprevention with natural products, especially the phytochemicals present in various edible and non-edible medicinal plants, has received significant interest over the last several years. 1 , 2 The discovery and development of several clinically used anticancer drugs (e.g.,vincristine and paclitaxel) have been originated from plant sources. 1 A great deal of research on identifying chemopreventive phytochemicals has explored a large number of plant secondary metabolites, such as carotenoids, alkaloids, flavonoids, chalcones, xanthones, coumarins and terpenoids, with anticancer properties.…”

Section: Introductionmentioning

confidence: 99%

“… 1 , 2 The discovery and development of several clinically used anticancer drugs (e.g.,vincristine and paclitaxel) have been originated from plant sources. 1 A great deal of research on identifying chemopreventive phytochemicals has explored a large number of plant secondary metabolites, such as carotenoids, alkaloids, flavonoids, chalcones, xanthones, coumarins and terpenoids, with anticancer properties. 1 A large number of laboratory-based as well as epidemiological studies have demonstrated the cancer chemopreventive effects of rosemary ( R. officinalis L.), 3 a Mediterranean herb that is commonly consumed as diet.…”

Section: Introductionmentioning

confidence: 99%

“… 1 A great deal of research on identifying chemopreventive phytochemicals has explored a large number of plant secondary metabolites, such as carotenoids, alkaloids, flavonoids, chalcones, xanthones, coumarins and terpenoids, with anticancer properties. 1 A large number of laboratory-based as well as epidemiological studies have demonstrated the cancer chemopreventive effects of rosemary ( R. officinalis L.), 3 a Mediterranean herb that is commonly consumed as diet. According to a case-control study, intake of diet containing rosemary can reduce the risk of lung cancer.…”

Section: Introductionmentioning

confidence: 99%

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Carnosol: A Phenolic Diterpene With Cancer Chemopreventive Potential

Chun¹,

Chae²,

Kundu³

2014

J Cancer Prev

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Cancer is an unbeaten health challenge for the humankind. After striving for decades to find a cancer cure, attention has now been shifted to reduce the morbidity and mortality from cancer by halting the course of tumor development. Numerous bioactive phytochemicals, especially those present in edible and non-edible plant species, have been reported to reduce the risk of many cancers. Multiple lines of evidence suggest that carnosol, a phenolic diterpene present in rosemary (Rosmarinus officinalis L.), holds the promise of preventing certain types of cancer. A remarkable progress has been made in delineating the biochemical mechanisms underlying the chemopreventive effects of carnosol. Results from in vitro cell culture studies as well as animal model experiments have revealed that carnosol inhibits experimentally induced carcinogenesis and exhibits potent anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties. Moreover, carnosol enhances the sensitivity of chemoresistant cancer cells to chemotherapeutic agents. The purpose of this review is to shed light on the detailed mechanistic aspects of cancer chemoprevention with carnosol.

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“…The extract after quantitative and qualitative analysis, could be used as a dietary supplement for astronauts, enriching the nutritional value of food. Before use the extract, will also be further purified, for example using chromatographic columns or filtration technique [14,16].…”

Section: Solid Waste Subsystemmentioning

confidence: 99%

Life support system in the mature Martian colony for 1000 people

et al. 2019

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The development in the field of space engineering is aimed at achieving another milestone, which is the creation of an extraterrestrial colony on, for example, Mars. Missions of this kind will be long-term and long-distance, which results in the need to design systems with a high degree of self-sufficiency. It is synonymous with high recovery resources. This article is a concept proposed for the needs of the Mar Colony Prize competition – Design The First Human Settlement On Mars, created by The Mars Society. This competition assumed designing highly-autonomous base for 1000 people. This means, that all environmental systems must be connected with each other and work in closed loops. In this paper four main environmental systems are proposed and characterized. The state of art of each subsystems technology is presented.

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Non-Edible Plants as an Attractive Source of Compounds with Chemopreventive Potential

Cited by 14 publications

References 21 publications

Phytoconstituents as apoptosis inducing agents: strategy to combat cancer

Phytoconstituents as apoptosis inducing agents: strategy to combat cancer

Carnosol: A Phenolic Diterpene With Cancer Chemopreventive Potential

Life support system in the mature Martian colony for 1000 people

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