Non-enzymatic free bilirubin electrochemical sensor based on ceria nanocube

Lu, Zhanjun; Cheng, Yarong; Zhang, Yuan; Wang, Xuefeng; Xu, Pengcheng; Yu, Haitao; Li, Xinxin

doi:10.1016/j.snb.2020.129224

Cited by 28 publications

(11 citation statements)

References 35 publications

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“…[35] An electrical signal was detected in a reconstituted bilirubin-spiked human serum sample in the linearity range of 1-100 μmol L −1 and no signal was detected in absence of bilirubin. [35] Potentially interfering molecules were also examined, and it was found that the oxidation peak of bilirubin was well separated from those molecules. [35] Another sensor was composed of a fluorine doped tin oxide glass plate as the working electrode, coated with graphene for better electrical conductivity, and combined with polypyrrole to further enhance the sensor's electrical conductivity and stability.…”

Section: Time-toresultsmentioning

confidence: 96%

“…Er-GR: 0.1 ± 0.018 MWCNT: 0.3 ± 0.022 94-106.5 30 5 min Screen-printed electrode; ceria nanocubes; carbon blacks [35] Electrochemical oxidation of bilirubin Electrochemistry 1-100 100 93-102.8 5 20 s…”

Section: Time-toresultsmentioning

confidence: 99%

“…[28] A similar non-enzymatic electrochemical bilirubin sensor was developed based on screen-printed electrodes modified with cerium oxide nanocubes as catalysts for oxidation and carbon blacks as electrical conductors. [35] Here, the oxidation of free bilirubin at the electrode was detected by cyclic voltammetry and differential pulse voltammetry from an electrochemical workstation. [35] An electrical signal was detected in a reconstituted bilirubin-spiked human serum sample in the linearity range of 1-100 μmol L −1 and no signal was detected in absence of bilirubin.…”

Section: Time-toresultsmentioning

confidence: 99%

“…[35] Potentially interfering molecules were also examined, and it was found that the oxidation peak of bilirubin was well separated from those molecules. [35] Another sensor was composed of a fluorine doped tin oxide glass plate as the working electrode, coated with graphene for better electrical conductivity, and combined with polypyrrole to further enhance the sensor's electrical conductivity and stability. [36] Bilirubin oxidase, which oxidizes bilirubin to biliverdin and hydrogen peroxide, was deposited on the modified electrode.…”

Section: Time-toresultsmentioning

confidence: 99%

See 3 more Smart Citations

175 Years of Bilirubin Testing: Ready for Point‐of‐Care?

Guirguis

Bertrand

Rose

et al. 2023

Adv Healthcare Materials

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Bilirubin was first detected in blood in 1847 and since then has become one of the most widely used biomarkers for liver disease. Clinical routine bilirubin testing is performed at the hospital laboratory, and the gold standard colorimetric test is prone to interferences. The absence of a bedside test for bilirubin delays critical clinical decisions for patients with liver disease. This clinical care gap has motivated the development of a new generation of bioengineered point-of-care bilirubin assays. In this Perspective, recently developed bilirubin assays are critically discussed, and their translational potential evaluated.

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Section: Time-toresultsmentioning

confidence: 96%

Section: Time-toresultsmentioning

confidence: 99%

Section: Time-toresultsmentioning

confidence: 99%

Section: Time-toresultsmentioning

confidence: 99%

See 2 more Smart Citations

175 Years of Bilirubin Testing: Ready for Point‐of‐Care?

Guirguis

Bertrand

Rose

et al. 2023

Adv Healthcare Materials

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show abstract

“…Pranab reported a colorimetric method for the detection of free bilirubin based on the peroxidase-like catalytic activity of gold nanoclusters [ 25 ]. Li et al prepared a non-enzymatic electrochemical sensor based on the high catalytic activity of cerium nanocubes, which could detect free bilirubin in a short response time [ 26 ]. Therefore, nanozymes would be a strong candidate for natural enzymes to bilirubin oxidation [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Enzymatically Colorimetric Bilirubin Sensing Based on the Catalytic Structure Disruption of Gold Nanocages

Xiao

Xiong

et al. 2023

Sensors

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As an essential indicator of liver function, bilirubin is of great significance for clinical diagnosis. A non-enzymatic sensor has been established for sensitive bilirubin detection based on the bilirubin oxidation catalyzed by unlabeled gold nanocages (GNCs). GNCs with dual-localized surface plasmon resonance (LSPR) peaks were prepared by a one-pot method. One peak around 500 nm was ascribed to gold nanoparticles (AuNPs), and the other located in the near-infrared region was the typical peak of GNCs. The catalytic oxidation of bilirubin by GNCs was accompanied by the disruption of cage structure, releasing free AuNPs from the nanocage. This transformation changed the dual peak intensities in opposite trend, and made it possible to realize the colorimetric sensing of bilirubin in a ratiometric mode. The absorbance ratios showed good linearity to bilirubin concentrations in the range of 0.20~3.60 μmol/L with a detection limit of 39.35 nM (3σ, n = 3). The sensor exhibited excellent selectivity for bilirubin over other coexisting substances. Bilirubin in real human serum samples was detected with recoveries ranging from 94.5 to 102.6%. The method for bilirubin assay is simple, sensitive and without complex biolabeling.

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Bimetallic MOF‐Based Fibrous Device for Noninvasive Bilirubin Sensing

Lu,

Xiao,

Wang

et al. 2024

Adv Materials Technologies

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Noninvasive and real‐time detection of bilirubin concentration enables rapid assessment of liver health status and the diagnosis of jaundice‐related diseases. Herein, the study proposes a strategy to uniformly grow bimetallic FeCo metal–organic framework (MOF) films onto the surface of carbonized electrospun nanofibers via a stepwise growth strategy involving an induction effect of oxide nanomembrane prepared by atomic layer deposition, to realize high‐performance flexible nanofiber bilirubin sensors. Compared with monometallic MOF, the FeCo bimetallic MOF can attain a larger specific surface area, thus augmenting the exposed active sites. Furthermore, the synergistic interaction between the bimetallic active sites on the MOF film and the carbonized nanofibers enhances the electronic conduction network, thereby significantly enhancing the catalytic activity of the flexible electrode for bilirubin. The current nanofibers sensor exhibits excellent performance in bilirubin detection, in terms of high sensitivity, large linear detection range, and low detection limit. The synthesis of bimetallic MOF films on flexible fibers holds promise for the development of highly sensitive electrodes for wearable bilirubin detection devices.

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Non-enzymatic free bilirubin electrochemical sensor based on ceria nanocube

Cited by 28 publications

References 35 publications

175 Years of Bilirubin Testing: Ready for Point‐of‐Care?

175 Years of Bilirubin Testing: Ready for Point‐of‐Care?

Non-Enzymatically Colorimetric Bilirubin Sensing Based on the Catalytic Structure Disruption of Gold Nanocages

Bimetallic MOF‐Based Fibrous Device for Noninvasive Bilirubin Sensing

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