Non-Enzymatic Glucose Biosensor Based on Highly Pure TiO2 Nanoparticles

Abstract

This study proposes a non-enzymatic glucose sensor fabricated by synthesizing high-purity TiO2 nanoparticles in thermal plasma and depositing it directly on a substrate and then depositing chitosan–polypyrrole (CS-PPy) conductive polymer films by electrochemical method. The structural properties of the deposited TiO2 nanoparticles were analyzed by X-ray diffraction (XRD) and dynamic light scattering (DLS) system. The chemical composition and structural properties of the TiO2 nanoparticle layer and the conductive polymer films were confirmed by X-ray photoelectron spectroscopy (XPS) spectra and scanning electron microscope (SEM). The glucose detection characteristics of the fabricated biosensor were determined by cyclic voltammetry (CV). CS-PPy/TiO2 biosensor showed high sensitivity of 302.0 µA mM−1 cm−2 (R2 = 0.9957) and low detection limit of 6.7 μM. The easily manufactured CS-PPy/TiO2 biosensor showed excellent selectivity and reactivity.

Recent Advances in Non-Enzymatic Glucose Sensors Based on Metal and Metal Oxide Nanostructures for Diabetes Management- A Review

“…There have been various studies done on titanium oxide-based sensors for glucose detection ( Song et al, 2011 ; AL-Mokaram et al, 2017 ; Grochowska et al, 2019 ; Jeong et al, 2021 ). TiO 2 acts as a direct photocatalyst in NEGS owing to its enhanced surface to volume ratio ( AL-Mokaram et al, 2017 ).…”

“…Adapted with permission from ref. ( Jeong et al, 2021 ), copyright@2021 (MDPI) (C) The electrochemical cell of Ppy-CS-TiO 2 film preparation. Adapted with permission from ref.…”

Selenium-based nanomaterials for biosensing applications

“… 112 As a result, patient-friendly, minimally invasive, or non-invasive fluorescence detection technologies have attracted interest, and some have made significant advances when combined with nanotechnology. The majority of these nanobiosensors are enzymatic or non-enzymatic and are based on the chemisorption of highly active glucose oxidase (GOx) onto AuNPs; 113 or by the chemical coating of different active components into carbon-based electrodes, such as high-purity TiO 2 , 114 silver (Ag) 115 or nickel (Ni) 116 in the nanoscale, among others.…”

Cr2O3–TiO2-Modified Filter Paper-Based Portable Nanosensors for Optical and Colorimetric Detection of Hydrogen Peroxide

“…Literature study has revealed a variety of advantages of nanomaterial-based peroxidase mimetics as they are not only easy and simple to synthesize but also efficient in working due to their tunable catalytic activity along with low cost and high stability. , Nanostructured titania (nTiO 2 ) is receiving enormous attention owing to its important applications in photocatalysis for environmental cleanup, solar cells, clean H 2 energy production, antimicrobial activity, food processing, and in glucose as well as gas sensing. , Also, TiO 2 nanoparticles are preferably chosen for the synthesis of nanocomposites as they act as an efficient synergizing modulator for mimicking peroxidase activity and lower toxicity . However, TiO 2 exhibits a large energy band gap of 3.2 eV and a lower photocatalytic activity when the recombination of charge carriers occurs. , These properties somehow limit its electron-transfer ability.…”

“…18,19 Nanostructured titania (nTiO 2 ) is receiving enormous attention owing to its important applications in photocatalysis for environmental cleanup, solar cells, clean H 2 energy production, antimicrobial activity, food processing, and in glucose as well as gas sensing. 20,21 Also, TiO 2 nanoparticles are preferably chosen for the synthesis of nanocomposites as they act as an efficient synergizing modulator for mimicking peroxidase activity and lower toxicity. 22 However, TiO 2 exhibits a large energy band gap of 3.2 eV 23 and a lower photocatalytic activity when the recombination of charge carriers occurs.…”