Non-erosive reflux disease rather than cervical inlet patch involves globus

Abstract

Non-erosive reflux disease was more closely associated with globus than an inlet patch. Our controversial results indicating a strong association of globus with non-erosive reflux disease and an inverse association of globus with reflux esophagitis may suggest that mechanisms other than gastroesophageal reflux as the etiology, such as an esophageal visceral hypersensitivity, involve globus.

Argon Plasma Coagulation of Gastric Inlet Patches for the Treatment of Globus Sensation: It Is an Effective Therapy in the Long Term

“…In this context it is worth noting that atypical reflux symptoms do not seem to respond to PPI therapy as well as typical reflux symptoms do [23]. However, it has been shown that the presence of CIP represent an independent risk factor for the development of globus sensation [7]. Our investigation could confirm this finding.…”

“…In fact, a multitude of organic disorders have been discussed as possible causes of globus sensation. Many authors have postulated a correlation between globus sensation and gastroesophageal reflux disease [6,7], and there is some evidence that a certain proportion of patients benefit from proton pump inhibitor (PPI) therapy [8]. On the other hand, there is also evidence that globus sensation is not related to gastroesophageal reflux disease and many patients complain about persistent symptoms despite taking PPIs [9,10].…”

Medical evaluation for patients with symptomatic esophageal disease

“…Nasal endoscopy and barium swallowing can help rule out pharyngeal pathology such as posterior laryngitis as well as fixed pharyngeal lesions ranging from pharyngeal pouches to supraglottic tumors [33]. Upper endoscopy can evaluate the upper esophageal mucosa for a gastric inlet patch, which has a weak association with globus symptoms [34]. If these study results are negative, physicians can focus on alleviating symptoms.…”

Heterotopic Gastric Mucosal Patch of the Proximal Esophagus

“…Narrow band imaging (NBI) which utilizes different light wavelengths has been reported to improve the detection rate of HGMP/CIP (Hori et al, 2010;Ohara, 2010). NBI allows better visualization of the more superficial features of mucosa.…”