Non-Familial Synchronous Double Primary Malignancies of the Gallbladder and Rectum

Gupta, Vishal; Goel, Madhu Mati; Kumari, Malti; Medappil, Noushif; Gandhi, Jatin; Chandra, Abhijit

doi:10.1007/s12029-013-9551-1

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…Various deoxyribonucleic acid (DNA) microsatellite instability (MSI)-related syndromes, such as Lynch I and II syndromes, are associated with the development of multiple primary tumors in various organs. The risk of developing malignancy of the biliary tract in Lynch syndrome is 2%-4% [ 8 ]. There is an increased risk of early-onset breast and ovarian cancer in members of families with breast cancer (BRCA) gene mutations [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…To date, ICC synchronous with HCC [ 15 ], ampullary carcinoid [ 16 ], lymphoma [ 17 ], lung squamous cell carcinoma [ 18 ], lymphoepithelioma [ 19 ], and renal cell carcinoma [ 20 ] have been reported, while few cases have been reported synchronous with thyroid carcinoma. Case reports of the synchronous primary gall bladder and rectal cancers have been published in the past [ 8 ]. Some studies suggest that their simultaneous occurrence is mainly due to gallstones and not to the genetic or hereditary risk.…”

Section: Discussionmentioning

confidence: 99%

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A Series of Biliary Tract Cancer With Coexistent Non-biliary Second Malignancy From Sub-Himalayan Region of India

Rajput

Gupta

et al. 2021

Cureus

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Background When researching female patients with breast or ovarian neoplasms, our research will sensitize oncologists to the prevalence of biliary tract cancers such that early cancers are not overlooked. Depending on different inherited, environmental, and iatrogenic risk factors, patients diagnosed with cancer have a risk of harboring another de novo malignancy. The additional primary identification of late has increased mainly due to progress in both diagnosis and treatment modalities, improvement in life expectancy, and understanding. Methods This is a descriptive study of retrospectively collected data from health records over 15 months, of patients who had biliary tract cancer and incidentally detected coexisting second non-biliary malignancy, from July 2018 to September 2019 at a tertiary care hospital. Details such as age, sex, smoking history, family history, occupation, body mass index (BMI), the organ involved, levels of tumor markers, treatment, and outcome were recorded. Results Six consecutive patients with biliary tract cancer presented during this duration and incidentally detected the second primary was ovarian cancer in three (50%) patients, breast carcinoma in two (33%) patients, and urinary bladder carcinoma in the remaining one patient (17%). The median age at diagnosis was 52.5 years with a range of 40-65 years. All patients were females (100%), non-smokers, homemaker, and without any history of cancer in family members. Only two patients who had a resectable disease were alive at one year’s follow-up. Conclusion The mechanisms of carcinogenesis in multiple primary malignancies are mainly genetic, epigenetics, and immunological. Prognosis, as well as the intent of treatment, depends on the respective stages of the two malignancies. In our study, most of the patients were in an advanced stage that demanded palliative care.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Series of Biliary Tract Cancer With Coexistent Non-biliary Second Malignancy From Sub-Himalayan Region of India

Rajput

Gupta

et al. 2021

Cureus

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“…According to Horii et al, microsatellite instabilities, due to mutations in mismatch repair genes, play a major role in the development of synchronous cancers [ 3 ]. For this reason, patients suffering from Lynch syndrome and Peutz-Jeghers syndrome are at a higher risk of synchronous billiary tract and colonic cancers [ 4 ]. Patients who have previously undergone chemotherapy or radiotherapy are also at a high risk [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Synchronous Primary Gallbladder and Sigmoid Colon Neoplasms

Galanis¹,

Lintzeris²,

Simou³

et al. 2023

Cureus

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Colorectal cancer is considered the third most common cancer worldwide. On the other hand, gallbladder cancer is rare. Synchronous tumors in both the colon and the gallbladder are extremely infrequent. Herein, we report the case of a female patient with sigmoid colon cancer and incidental detection of synchronous gallbladder cancer on histopathological examination of the surgical specimen. As synchronous gallbladder and colonic carcinomas are rare, physicians should be aware of these so that an optimal course of treatment can be chosen.

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A Sordid Tale of Bile and Bowel

Kattepur

Nadipanna

Deepak

et al. 2022

World Journal of Colorectal Surgery

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Synchronous tumors of gall bladder and colon cancer are rare, and the underlying genetic, environmental, and immunological factors could play a role in the development of such tumors. Till date, only a few cases of synchronous gall bladder and colonic malignancies have been reported. A 60-year-old lady presented with sub-acute onset of colicky pain in the abdomen and vomiting. Imaging showed the presence of thickening in the ileocecal junction along with a thickened gall bladder. A provisional diagnosis of gall bladder tumour with ileocecal tuberculosis or a synchronous colonic malignancy was made. Laparotomy revealed synchronous tumors in the gall bladder and caecum. Radical cholecystectomy with radical right hemicolectomy was performed. The final histopathology report confirmed the presence of two independent malignancies. A tailored treatment approach for both sites based on clinical findings and anticipated outcomes must be considered. Further immunohistochemical studies must be conducted to confirm the presence of dual malignancies. Metastases from one site to the other should be ruled out.

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Non-Familial Synchronous Double Primary Malignancies of the Gallbladder and Rectum

Cited by 3 publications

References 6 publications

A Series of Biliary Tract Cancer With Coexistent Non-biliary Second Malignancy From Sub-Himalayan Region of India

A Series of Biliary Tract Cancer With Coexistent Non-biliary Second Malignancy From Sub-Himalayan Region of India

A Rare Case of Synchronous Primary Gallbladder and Sigmoid Colon Neoplasms

A Sordid Tale of Bile and Bowel

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